A two‐component signal‐transducing system is involved in competence and penicillin susceptibility in laboratory mutants of Streptococcus pneumoniae

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A rapid alkaline extraction procedure for screening recombinant plasmid DNA

1979 • 15,511 citations

STUDIES ON THE CHEMICAL NATURE OF THE SUBSTANCE INDUCING TRANSFORMATION OF PNEUMOCOCCAL TYPES

1944 • 3,183 citations

One-step preparation of competent Escherichia coli: transformation and storage of bacterial cells in the same solution.

1989 • 1,585 citations

Protein phosphorylation and regulation of adaptive responses in bacteria

1989 • 1,495 citations

COMMUNICATION MODULES IN BACTERIAL SIGNALING PROTEINS

1992 • 1,449 citations

Handbook of Experimental Pharmacology

1968 • 789 citations

Protein phosphorylation and regulation of adaptive responses in bacteria.

1989 • 694 citations

A study of the genetic material determining an enzyme activity in Pneumococcus

1960 • 548 citations

A highly conserved repeated DNA element located in the chromosome ofStreptococcus pneumoniae

1992 • 381 citations

The VanS-VanR two-component regulatory system controls synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147

1992 • 327 citations

Interspecies recombinational events during the evolution of altered PBP 2x genes in penicillin‐resistant clinical isolates of Streptococcus pneumoniae

1991 • 280 citations

REGULATION OF THE TRANSFORMABILITY OF PNEUMOCOCCAL CULTURES BY MACROMOLECULAR CELL PRODUCTS

1964 • 246 citations

Nucleotide sequence of the phoB gene, the positive regulatory gene for the phosphate regulon of Escherichia coli K-12

1986 • 240 citations

Mutant isolation and molecular cloning of mre genes, which determine cell shape, sensitivity to mecillinam, and amount of penicillin-binding proteins in Escherichia coli

1987 • 236 citations

Mutants of Diplococcus pneumoniae that Lack Deoxyribonucleases and Other Activities Possibly Pertinent to Genetic Transformation

1970 • 198 citations

Osmoregulation of gene expression. I. DNA sequence of the ompR gene of the ompB operon of Escherichia coli and characterization of its gene product.

1982 • 193 citations

A Bacillus subtilis regulatory gene product for genetic competence and sporulation resembles sensor protein members of the bacterial two-component signal-transduction systems.

1990 • 192 citations

EnvZ controls the concentration of phosphorylated OmpR to mediate osmoregulation of the porin genes

1991 • 186 citations

femA, which encodes a factor essential for expression of methicillin resistance, affects glycine content of peptidoglycan in methicillin-resistant and methicillin-susceptible Staphylococcus aureus strains

1991 • 181 citations

Genetic transformation in Streptococcus pneumoniae: nucleotide sequence analysis shows comA, a gene required for competence induction, to be a member of the bacterial ATP-dependent transport protein family

1991 • 158 citations

Cloning of Streptococcus pneumoniae DNA fragments in Escherichia coli requires vectors protected by strong transcriptional terminators

1987 • 126 citations

On the nature of the pneumococcal activator substance.

1966 • 126 citations

Nucleotide sequence of the phoR gene, a regulatory gene for the phosphate regulon of Escherichia coli

1986 • 125 citations

Nucleotide sequences of the pbpX genes encoding the penicillin‐binding proteins 2x from Streptococcus pneumoniae R6 and a cefotaxime‐resistant mutant, C506

1989 • 120 citations

Penicillin binding protein 2 is dispensable in Escherichia coli when ppGpp synthesis is induced.

1992 • 111 citations

Isolation of transformation-deficient Streptococcus pneumoniae mutants defective in control of competence, using insertion-duplication mutagenesis with the erythromycin resistance determinant of pAM beta 1

1984 • 109 citations

Sequence and transcription mapping of Bacillus subtilis competence genes comB and comA, one of which is related to a family of bacterial regulatory determinants

1989 • 103 citations

Altered muropeptide composition in Staphylococcus aureus strains with an inactivated femA locus

1993 • 102 citations

Isolation and characterization of three new classes of transformation-deficient mutants of Streptococcus pneumoniae that are defective in DNA transport and genetic recombination

1983 • 94 citations

The regulation of genetic competence in Bacillus subtilis

1991 • 94 citations

Osmoregulation of gene expression. II. DNA sequence of the envZ gene of the ompB operon of Escherichia coli and characterization of its gene product.

1982 • 94 citations

Five independent combinations of mutations can result in low-affinity penicillin-binding protein 2x of Streptococcus pneumoniae

1991 • 93 citations

Interaction of Non-lytic -Lactams with Penicillin-binding Proteins in Streptococcus pneumoniae

1987 • 89 citations

PENICILLIN RESISTANCE OF COMPETENT CELLS IN DEOXYRIBONUCLEIC ACID TRANSFORMATION OF BACILLUS SUBTILIS

1964 • 88 citations

Gene localization, size, and physical map of the chromosome of Streptococcus pneumoniae

1991 • 85 citations

Penicillin‐binding proteins in β‐lactam‐resistant laboratory mutants of Streptococcus pneumoniae

1987 • 77 citations

Structure and expression of the ompB operon, the regulatory locus for the outer membrane porin regulon in Salmonella typhimurium LT-2

1988 • 68 citations

Overproduction of a penicillin-binding protein is not the only mechanism of penicillin resistance in Enterococcus faecium

1992 • 56 citations

Genetic and physiological analysis of an envB spherelike mutant of Escherichia coli K-12 and characterization of its transductants

1975 • 49 citations

Competence for genetic transformation in Streptococcus pneumoniae: molecular cloning of com, a competence control locus

1987 • 49 citations

MARKER DISCRIMINATION AND MUTAGEN-INDUCED ALTERATIONS IN PNEUMOCOCCAL TRANSFORMATION

1974 • 44 citations

Transmembrane signal transduction and osmoregulation in Escherichia coli. Functional importance of the periplasmic domain of the membrane-located protein kinase, EnvZ.

1991 • 44 citations

STEPWISE INTRODUCTION OF TRANSFORMABLE PENICILLIN RESISTANCE IN PNEUMOCOCCUS

1970 • 36 citations

Coaching Young Athletes: Strategies for Success

1989 • 29 citations

A plasmid vector allowing positive selection of recombinant plasmids in Streptococcus pneumoniae

1985 • 22 citations

The role of penicillin-binding protein 3 (PBP 3) in cefotaxime resistance in Streptococcus pneumoniae

1993 • 14 citations

Genetic studies of cefotaxime resistance in Streptococcus pneumoniae: relationship to transformation deficiency

1993 • 6 citations