Conservation of structure and function among histidine-containing phosphotransfer (HPt) domains as revealed by the crystal structure of YPD1 1 1Edited by I. A. Wilson

[20] Processing of X-ray diffraction data collected in oscillation mode

1997 • 33,348 citations

PROCHECK: a program to check the stereochemical quality of protein structures

1993 • 23,689 citations

The CCP4 suite: programs for protein crystallography

1994 • 17,203 citations

Refinement of Macromolecular Structures by the Maximum-Likelihood Method

1997 • 14,729 citations

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

Two-Component Signal Transduction

2000 • 3,517 citations

WHAT IF: A molecular modeling and drug design program

1990 • 3,484 citations

Principles of protein-protein interactions.

1996 • 2,594 citations

Crystallographic R Factor Refinement by Molecular Dynamics

1987 • 1,982 citations

[27] Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods

1997 • 1,905 citations

Improved Fourier coefficients for maps using phases from partial structures with errors

1986 • 1,897 citations

An extensively modified version of MolScript that includes greatly enhanced coloring capabilities

1997 • 1,724 citations

SETOR: Hardware-lighted three-dimensional solid model representations of macromolecules

1993 • 1,295 citations

An Osmosensing Signal Transduction Pathway in Yeast

1993 • 1,252 citations

SGD: Saccharomyces Genome Database

1998 • 1,138 citations

Methods used in the structure determination of bovine mitochondrial F1 ATPase

1996 • 1,101 citations

A two-component system that regulates an osmosensing MAP kinase cascade in yeast

1994 • 1,091 citations

PROMOTIF—A program to identify and analyze structural motifs in proteins

1996 • 1,046 citations

Yeast HOG1 MAP Kinase Cascade Is Regulated by a Multistep Phosphorelay Mechanism in the SLN1–YPD1–SSK1 “Two-Component” Osmosensor

1996 • 876 citations

The structure of protein-protein recognition sites.

1990 • 825 citations

International Tables for Crystallography

2016 • 658 citations

Activation of Yeast PBS2 MAPKK by MAPKKKs or by Binding of an SH3-Containing Osmosensor

1995 • 649 citations

GPD1, Which Encodes Glycerol-3-Phosphate Dehydrogenase, Is Essential for Growth under Osmotic Stress in Saccharomyces cerevisiae, and Its Expression Is Regulated by the High-Osmolarity Glycerol Response Pathway

1994 • 630 citations

GPD1, which encodes glycerol-3-phosphate dehydrogenase, is essential for growth under osmotic stress in Saccharomyces cerevisiae, and its expression is regulated by the high-osmolarity glycerol response pathway.

1994 • 539 citations

[25] Ribbons

1997 • 511 citations

Two-component signal transduction

1995 • 502 citations

Practical Protein Crystallography

1999 • 496 citations

[57] Genetic and physical maps of Saccharomyces cerevisiae

1991 • 488 citations

A Yeast Protein Similar to Bacterial Two-Component Regulators

1993 • 431 citations

Signal Transduction via the Multi-Step Phosphorelay: Not Necessarily a Road Less Traveled

1996 • 427 citations

Dali/FSSP classification of three-dimensional protein folds

1997 • 423 citations

Compilation of All Genes Encoding Two-component Phosphotransfer Signal Transducers in the Genome of Escherichia coli

1997 • 384 citations

Torsion angle dynamics: Reduced variable conformational sampling enhances crystallographic structure refinement

1994 • 369 citations

Roles of glycerol and glycerol-3-phosphate dehydrogenase (NAD+) in acquired osmotolerance of Saccharomyces cerevisiae

1989 • 297 citations

Activation of the yeast SSK2 MAP kinase kinase kinase by the SSK1 two-component response regulator

1998 • 289 citations

Two-component signal transducers and MAPK cascades

1997 • 288 citations

The Skn7 response regulator controls gene expression in the oxidative stress response of the budding yeast Saccharomyces cerevisiae

1997 • 284 citations

The Two-Component System1

1998 • 263 citations

Two-Component Signal Transduction Systems: Structure-Function Relationships and Mechanisms of Catalysis

2014 • 258 citations

Structure of the magnesium-bound form of CheY and mechanism of phosphoryl transfer in bacterial chemotaxis

1993 • 215 citations

The yeast histidine protein kinase, Sln1p, mediates phosphotransfer to two response regulators, Ssk1p and Skn7p

1998 • 183 citations

Histidine kinases in signal transduction pathways of eukaryotes

1997 • 173 citations

The application of direct methods and Patterson interpretation to high-resolution native protein data

1993 • 161 citations

SKN7, a yeast multicopy suppressor of a mutation affecting cell wall beta-glucan assembly, encodes a product with domains homologous to prokaryotic two-component regulators and to heat shock transcription factors

1993 • 159 citations

Insights into Multistep Phosphorelay from the Crystal Structure of the C-Terminal HPt Domain of ArcB

1997 • 159 citations

Yeast Skn7p functions in a eukaryotic two-component regulatory pathway.

1994 • 155 citations

Signalling pathways in two-component phosphorelay systems

1999 • 153 citations

The response regulator-like protein Pos9/Skn7 ofSaccharomyces cerevisiae is involved in oxidative stress resistance

1996 • 151 citations

Efficient Rebuilding of Protein Structures

1996 • 148 citations

Characterization of the osmotic-stress response inSaccharomyces cerevisiae: osmotic stress and glucose repression regulate glycerol-3-phosphate dehydrogenase independently

1994 • 126 citations

The crystal structure of succinyl-CoA synthetase from Escherichia coli at 2.5-A resolution.

1994 • 123 citations

South African museums' status ‘at risk’

1997 • 122 citations

Mechanism of phosphate transfer by nucleoside diphosphate kinase: X-ray structures of the phosphohistidine intermediate of the enzymes from Drosophila and Dictyostelium

1995 • 117 citations

The crystal structure of succinyl-CoA synthetase from Escherichia coli at 2.5-A resolution.

1994 • 117 citations

Osmostress response of the yeast Saccharomyces

1993 • 111 citations

Formation of a Novel Four-Helix Bundle and Molecular Recognition Sites by Dimerization of a Response Regulator Phosphotransferase

1998 • 108 citations

The first step in sugar transport: crystal structure of the amino terminal domain of enzyme I of the E. coli PEP: sugar phosphotransferase system and a model of the phosphotransfer complex with HPr

1996 • 105 citations

Phosphorylation in halobacterial signal transduction.

1995 • 94 citations

Yeast Skn7p activity is modulated by the Sln1p-Ypd1p osmosensor and contributes to regulation of the HOG pathway

1998 • 83 citations

Template Convolution to Enhance or Detect Structural Features in Macromolecular Electron-Density Maps

1997 • 80 citations

NMR studies of the phosphotransfer domain of the histidine kinase CheA from Escherichia coli: assignments, secondary structure, general fold, and backbone dynamics

1995 • 79 citations

Evidence that the RdeA protein is a component of a multistep phosphorelay modulating rate of development in Dictyostelium

1998 • 73 citations

Specificity of the BvgAS and EvgAS phosphorelay is mediated by the C‐terminal HPt domains of the sensor proteins

1998 • 71 citations

Structure of the IIA Domain of the Mannose Transporter fromEscherichia coliat 1.7 Å Resolution

1996 • 64 citations

Differential Stabilities of Phosphorylated Response Regulator Domains Reflect Functional Roles of the Yeast Osmoregulatory SLN1 and SSK1 Proteins

1999 • 58 citations

Phosphotransfer Site of the Chemotaxis-Specific Protein Kinase CheA as Revealed by NMR

1997 • 54 citations

The structure of the Escherichia coli phosphotransferase IIAmannitol reveals a novel fold with two conformations of the active site

1998 • 48 citations

Activated Alleles of Yeast SLN1 Increase Mcm1-dependent Reporter Gene Expression and Diminish Signaling through the Hog1 Osmosensing Pathway

1997 • 46 citations

The Essential Transcription Factor, Mcm1, Is a Downstream Target of Sln1, a Yeast "Two-component" Regulator

1995 • 38 citations

Phosphohistidines in bacterial signaling

1997 • 35 citations

Phosphorelay signalling: New tricks for an ancient pathway

1998 • 25 citations

Phosphorylation of the Spo0B Response Regulator Phosphotransferase of the Phosphorelay Initiating Development in Bacillus subtilis

1998 • 22 citations

Purification, crystallization and preliminary X-ray diffraction analysis of the yeast phosphorelay protein YPD1

1999 • 13 citations