MEK/ERK-Mediated Phosphorylation of Bim Is Required to Ensure Survival of T and B Lymphocytes during Mitogenic Stimulation

The Pathophysiology of Mitochondrial Cell Death

2004 • 3,258 citations

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

1996 • 2,627 citations

Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms

1999 • 1,897 citations

Proapoptotic Bcl-2 Relative Bim Required for Certain Apoptotic Responses, Leukocyte Homeostasis, and to Preclude Autoimmunity

1999 • 1,500 citations

ER Stress Triggers Apoptosis by Activating BH3-Only Protein Bim

2007 • 1,353 citations

p53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa

2003 • 1,298 citations

Apoptosis Signaling

2000 • 1,290 citations

Bim: a novel member of the Bcl-2 family that promotes apoptosis

1998 • 1,154 citations

Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak

2007 • 1,110 citations

Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

1988 • 1,086 citations

JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

2003 • 1,045 citations

BH3-Only Proteins—Essential Initiators of Apoptotic Cell Death

2000 • 1,033 citations

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

2000 • 983 citations

Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

2003 • 862 citations

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

2002 • 772 citations

Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

2002 • 699 citations

The role of BH3-only proteins in the immune system

2005 • 608 citations

Activation of the ERK1/2 Signaling Pathway Promotes Phosphorylation and Proteasome-dependent Degradation of the BH3-only Protein, Bim

2003 • 607 citations

Activated T Cell Death In Vivo Mediated by Proapoptotic Bcl-2 Family Member Bim

2002 • 564 citations

Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function

2003 • 466 citations

Induction of BIM, a Proapoptotic BH3-Only BCL-2 Family Member, Is Critical for Neuronal Apoptosis

2001 • 453 citations

Control of Apoptosis in the Immune System: Bcl-2, BH3-Only Proteins and More

2003 • 387 citations

Constitutive Bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival

1999 • 354 citations

Bim and Bad mediate imatinib-induced killing of Bcr/Abl ⁺ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic

2006 • 331 citations

Regulatory phosphorylation of Bim: sorting out the ERK from the JNK

2005 • 303 citations

Loss of the Pro-Apoptotic BH3-only Bcl-2 Family Member Bim Inhibits BCR Stimulation–induced Apoptosis and Deletion of Autoreactive B Cells

2003 • 296 citations

Degenerative Disorders Caused by Bcl-2 Deficiency Prevented by Loss of Its BH3-Only Antagonist Bim

2001 • 270 citations

Bad -deficient mice develop diffuse large B cell lymphoma

2003 • 268 citations

BH3-only proteins Puma and Bim are rate-limiting for γ-radiation– and glucocorticoid-induced apoptosis of lymphoid cells in vivo

2005 • 262 citations

Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim

2003 • 239 citations

Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim

2003 • 229 citations

The Proapoptotic BH3-Only Protein Bim Is Expressed in Hematopoietic, Epithelial, Neuronal, and Germ Cells

2000 • 227 citations

Multisite Phosphorylation Regulates Bim Stability and Apoptotic Activity

2008 • 225 citations

Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction

2006 • 225 citations

Size Control: The Regulation of Cell Numbers in Animal Development

1996 • 202 citations

The BH3-Only Protein Bid Is Dispensable for DNA Damage- and Replicative Stress-Induced Apoptosis or Cell-Cycle Arrest

2007 • 201 citations

BAFF regulates B cell survival by downregulating the BH3-only family member Bim via the ERK pathway

2005 • 193 citations

Extracellular Signal-regulated Kinases 1/2 Are Serum-stimulated “BimEL Kinases” That Bind to the BH3-only Protein BimEL Causing Its Phosphorylation and Turnover

2004 • 191 citations

ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL

2007 • 169 citations

Generalized Resistance to Thymic Deletion in the NOD Mouse

2004 • 157 citations

The MAP kinase pathway is required for entry into mitosis and cell survival

2004 • 156 citations

Fatal Hepatitis Mediated by Tumor Necrosis Factor TNFα Requires Caspase-8 and Involves the BH3-Only Proteins Bid and Bim

2009 • 134 citations

The Pro-apoptotic Protein Bim Is a Convergence Point for cAMP/Protein Kinase A- and Glucocorticoid-promoted Apoptosis of Lymphoid Cells

2004 • 131 citations

Proapoptotic BH3-only protein Bim is essential for developmentally programmed death of germinal center-derived memory B cells and antibody-forming cells

2007 • 107 citations

Regulation of expression of Bcl-2 protein family member Bim by T cell receptor triggering

2004 • 75 citations

The p38 Mitogen-Activated Protein Kinase Pathway in Activated and Anergic Th1 Cells

1997 • 53 citations

Generalized Resistance to Thymic Deletion in the NOD MouseA Polygenic Trait Characterized by Defective Induction of Bim

2004 • 48 citations

Phosphorylation of the pro-apoptotic protein Bim in lymphocytes is associated with protection from apoptosis

2003 • 47 citations

Growth-factor-dependent phosphorylation of Bim in mitosis

2005 • 17 citations

TLR-dependent Bim phosphorylation in macrophages is mediated by ERK and is connected to proteasomal degradation of the protein

2006 • 15 citations