Extracellular Signal-regulated Kinases 1/2 Are Serum-stimulated “BimEL Kinases” That Bind to the BH3-only Protein BimEL Causing Its Phosphorylation and Turnover

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

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Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

1998 • 4,383 citations

The Bcl2 family: regulators of the cellular life-or-death switch

2002 • 3,782 citations

PUMA, a Novel Proapoptotic Gene, Is Induced by p53

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The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis

2000 • 2,064 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

Bim: a novel member of the Bcl-2 family that promotes apoptosis

1998 • 1,154 citations

The Proapoptotic Activity of the Bcl-2 Family Member Bim Is Regulated by Interaction with the Dynein Motor Complex

1999 • 1,045 citations

JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

2003 • 1,045 citations

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

2000 • 983 citations

Sequence-Specific and Phosphorylation-Dependent Proline Isomerization: A Potential Mitotic Regulatory Mechanism

1997 • 762 citations

Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

2002 • 699 citations

Structural basis for phosphoserine-proline recognition by group IV WW domains.

2000 • 677 citations

Function of WW Domains as Phosphoserine- or Phosphothreonine-Binding Modules

1999 • 663 citations

FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons

2003 • 635 citations

Phosphorylation and Inactivation of BAD by Mitochondria-Anchored Protein Kinase A

1999 • 635 citations

14-3-3 Proteins and Survival Kinases Cooperate to Inactivate BAD by BH3 Domain Phosphorylation

2000 • 634 citations

Activation of the ERK1/2 Signaling Pathway Promotes Phosphorylation and Proteasome-dependent Degradation of the BH3-only Protein, Bim

2003 • 607 citations

Dominant-Negative c-Jun Promotes Neuronal Survival by Reducing BIM Expression and Inhibiting Mitochondrial Cytochrome c Release

2001 • 568 citations

Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1

2001 • 525 citations

JNK-Mediated BIM Phosphorylation Potentiates BAX-Dependent Apoptosis

2003 • 512 citations

Pin1 regulates turnover and subcellular localization of β-catenin by inhibiting its interaction with APC

2001 • 460 citations

Induction of BIM, a Proapoptotic BH3-Only BCL-2 Family Member, Is Critical for Neuronal Apoptosis

2001 • 453 citations

Docking domains and substrate-specificity determination for MAP kinases

2000 • 430 citations

Molecular mechanisms mediating mammalian mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK cell survival signals.

2001 • 425 citations

Differential targeting of MAP kinases to the ETS-domain transcription factor Elk-1

1998 • 302 citations

Rsk1 mediates a MEK–MAP kinase cell survival signal

2000 • 290 citations

Identification of Novel Isoforms of the BH3 Domain Protein Bim Which Directly Activate Bax To Trigger Apoptosis

2002 • 287 citations

Downregulation of Bim, a Proapoptotic Relative of Bcl-2, Is a Pivotal Step in Cytokine-Initiated Survival Signaling in Murine Hematopoietic Progenitors

2001 • 210 citations

Nerve Growth Factor (NGF) Down-regulates the Bcl-2 Homology 3 (BH3) Domain-only Protein Bim and Suppresses Its Proapoptotic Activity by Phosphorylation

2002 • 177 citations

Activation of ERK1/2 by ΔRaf-1 : ER* represses Bim expression independently of the JNK or PI3K pathways

2003 • 172 citations

Gene structure, alternative splicing, and chromosomal localization of pro-apoptotic Bcl-2 relative Bim

2001 • 140 citations

Docking interactions in the mitogen-activated protein kinase cascades

2002 • 128 citations

BOD (Bcl-2-Related Ovarian Death Gene) Is an Ovarian BH3 Domain-Containing Proapoptotic Bcl-2 Protein Capable of Dimerization with Diverse Antiapoptotic Bcl-2 Members

1998 • 128 citations

Protein modification: Docking sites for kinases

1999 • 124 citations

Cell-cycle arrest by PD184352 requires inhibition of extracellular signal-regulated kinases (ERK) 1/2 but not ERK5/BMK1

2002 • 102 citations

Drosophila Pin1 prolyl isomerase Dodo is a MAP kinase signal responder during oogenesis

2001 • 82 citations

ΔMEKK3:ER* activation induces a p38α/β2-dependent cell cycle arrest at the G2 checkpoint

2002 • 51 citations

Phosphorylation of the pro-apoptotic protein Bim in lymphocytes is associated with protection from apoptosis

2003 • 47 citations

Cell cycle-dependent phosphorylation of Disabled-2 by cdc2

2003 • 43 citations

Analysis of the Interaction between c-Jun and c-Jun N-terminal Kinase in Vivo

1998 • 39 citations