Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction

Differential Targeting of Prosurvival Bcl-2 Proteins by Their BH3-Only Ligands Allows Complementary Apoptotic Function

2005 • 1,751 citations

Proapoptotic Bcl-2 Relative Bim Required for Certain Apoptotic Responses, Leukocyte Homeostasis, and to Preclude Autoimmunity

1999 • 1,500 citations

p53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa

2003 • 1,298 citations

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

2006 • 1,214 citations

BH3 Domains of BH3-Only Proteins Differentially Regulate Bax-Mediated Mitochondrial Membrane Permeabilization Both Directly and Indirectly

2005 • 1,152 citations

Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

2003 • 862 citations

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

2001 • 815 citations

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

2002 • 772 citations

Life in the balance: how BH3-only proteins induce apoptosis

2005 • 744 citations

The role of BH3-only proteins in the immune system

2005 • 608 citations

The Forkhead Transcription Factor FoxO Regulates Transcription of p27Kip1 and Bim in Response to IL-2

2002 • 580 citations

Activated T Cell Death In Vivo Mediated by Proapoptotic Bcl-2 Family Member Bim

2002 • 564 citations

Bim is a suppressor of Myc-induced mouse B cell leukemia

2004 • 485 citations

Control points in early T-cell development

1993 • 429 citations

FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal

2006 • 392 citations

The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry.

1996 • 384 citations

Constitutive Bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival

1999 • 354 citations

Integral role of Noxa in p53-mediated apoptotic response

2003 • 326 citations

Loss of the Pro-Apoptotic BH3-only Bcl-2 Family Member Bim Inhibits BCR Stimulation–induced Apoptosis and Deletion of Autoreactive B Cells

2003 • 296 citations

Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis

2002 • 293 citations

Degenerative Disorders Caused by Bcl-2 Deficiency Prevented by Loss of Its BH3-Only Antagonist Bim

2001 • 270 citations

BH3-only proteins Puma and Bim are rate-limiting for γ-radiation– and glucocorticoid-induced apoptosis of lymphoid cells in vivo

2005 • 262 citations

Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim

2003 • 229 citations

VavP-Bcl2 transgenic mice develop follicular lymphoma preceded by germinal center hyperplasia

2003 • 204 citations

Bcl-XL displays restricted distribution during T cell development and inhibits multiple forms of apoptosis but not clonal deletion in transgenic mice.

1995 • 178 citations

Suppression of tumorigenesis by the p53 target PUMA

2004 • 178 citations

BH3-only proteins in cell death initiation, malignant disease and anticancer therapy

2006 • 164 citations

Pre-TCR Signaling and Inactivation of p53 Induces Crucial Cell Survival Pathways in Pre-T Cells

1999 • 122 citations

Concomitant loss of proapoptotic BH3-only Bcl-2 antagonists Bik and Bim arrests spermatogenesis

2005 • 97 citations

Mutually Exclusive Subsets of BH3-Only Proteins Are Activated by the p53 and c-Jun N-Terminal Kinase/c-Jun Signaling Pathways during Cortical Neuron Apoptosis Induced by Arsenite

2005 • 79 citations

Negative selection of semimature CD4 ⁺ 8 ^- HSA ⁺ thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling

2004 • 71 citations

Loss of Bim Allows Precursor B Cell Survival But Not Precursor B Cell Differentiation in the Absence of Interleukin 7

2004 • 46 citations

Inhibition of B Cell Death Causes the Development of an IgA Nephropathy in (New Zealand White × C57BL/6)F1-bcl-2 Transgenic Mice

2004 • 41 citations