Regulatory phosphorylation of Bim: sorting out the ERK from the JNK

The Hallmarks of Cancer

2000 • 27,569 citations

Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway

2000 • 1,703 citations

Proapoptotic Bcl-2 Relative Bim Required for Certain Apoptotic Responses, Leukocyte Homeostasis, and to Preclude Autoimmunity

1999 • 1,500 citations

A Divergence in the MAP Kinase Regulatory Network Defined by MEK Kinase and Raf

1993 • 1,086 citations

JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

2003 • 1,045 citations

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

2002 • 772 citations

FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons

2003 • 635 citations

Dominant-Negative c-Jun Promotes Neuronal Survival by Reducing BIM Expression and Inhibiting Mitochondrial Cytochrome c Release

2001 • 568 citations

Activated T Cell Death In Vivo Mediated by Proapoptotic Bcl-2 Family Member Bim

2002 • 564 citations

JNK-Mediated BIM Phosphorylation Potentiates BAX-Dependent Apoptosis

2003 • 512 citations

c-Jun Can Recruit JNK to Phosphorylate Dimerization Partners via Specific Docking Interactions

1996 • 495 citations

Bim is a suppressor of Myc-induced mouse B cell leukemia

2004 • 485 citations

Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function

2003 • 466 citations

Induction of BIM, a Proapoptotic BH3-Only BCL-2 Family Member, Is Critical for Neuronal Apoptosis

2001 • 453 citations

Genome-wide array-based CGH for mantle cell lymphoma: identification of homozygous deletions of the proapoptotic gene BIM

2004 • 308 citations

Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity

2004 • 286 citations

Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim

2003 • 229 citations

Activation of ERK1/2 by ΔRaf-1 : ER* represses Bim expression independently of the JNK or PI3K pathways

2003 • 172 citations

Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells

2004 • 128 citations

Role of Bim in the survival pathway induced by Raf in epithelial cells

2003 • 114 citations

Characterization of the c-Jun N-Terminal Kinase-Bim_ELSignaling Pathway in Neuronal Apoptosis

2004 • 112 citations

Dimerization and Folding of LC8, a Highly Conserved Light Chain of Cytoplasmic Dynein

2001 • 78 citations

Application of proteasomal inhibitors to mouse sympathetic neurons activates the intrinsic apoptotic pathway

2004 • 53 citations

Selective activation of the c-Jun N-terminal kinase (JNK) pathway fails to elicit Bax activation or apoptosis unless the phosphoinositide 3′-kinase (PI3K) pathway is inhibited

2003 • 49 citations

B Cell Receptor-Mediated Apoptosis of Human Lymphocytes Is Associated with a New Regulatory Pathway of Bim Isoform Expression

2004 • 38 citations