Resistance of Mammalian Tumor Cells to Inhibitors of DNA Topoisomerase II

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms.

1989 • 3,707 citations

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

1992 • 3,039 citations

Universal control mechanism regulating onset of M-phase

1990 • 2,882 citations

Adriamycin-Induced DNA Damage Mediated by Mammalian DNA Topoisomerase II

1984 • 1,477 citations

Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note.

1989 • 937 citations

Poly(ADP-Ribose) in the Cellular Response to DNA Damage

1985 • 771 citations

Glucocorticoids activate a suicide process in thymocytes through an elevation of cytosolic Ca2+ concentration

1989 • 549 citations

Novel inhibitors of poly(ADP-ribose) synthetase

1980 • 519 citations

The cdc25 protein controls tyrosine dephosphorylation of the cdc2 protein in a cell-free system

1991 • 504 citations

DNA topoisomerase-targeting antitumor drugs can be studied in yeast.

1988 • 490 citations

In situ localization of DNA topoisomerase II, a major polypeptide component of the Drosophila nuclear matrix fraction.

1985 • 472 citations

Proliferation- and cell cycle-dependent differences in expression of the 170 kilodalton and 180 kilodalton forms of topoisomerase II in NIH-3T3 cells.

1991 • 450 citations

Isolation of type I and II DNA topoisomerase mutants from fission yeast: single and double mutants show different phenotypes in cell growth and chromatin organization.

1984 • 444 citations

Biochemical and pharmacological properties of p170 and p180 forms of topoisomerase II

1989 • 409 citations

Energy coupling in DNA gyrase and the mechanism of action of novobiocin

1978 • 403 citations

Topoisomerase II-reactive chemotherapeutic drugs induce apoptosis in thymocytes.

1991 • 392 citations

Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22.

1988 • 391 citations

The organisation of chromatin loops: characterization of a scaffold attachment site

1986 • 308 citations

Purification of topoisomerase II from amsacrine-resistant P388 leukemia cells. Evidence for two forms of the enzyme.

1987 • 282 citations

Multifactorial drug resistance in an adriamycin-resistant human small cell lung carcinoma cell line.

1987 • 266 citations

Direct correlation between DNA topoisomerase II activity and cytotoxicity in adriamycin-sensitive and -resistant P388 leukemia cell lines.

1989 • 263 citations

Characterization and immunological identification of cDNA clones encoding two human DNA topoisomerase II isozymes.

1989 • 250 citations

Protein kinase C phosphorylates topoisomerase II: topoisomerase activation and its possible role in phorbol ester-induced differentiation of HL-60 cells.

1986 • 231 citations

Atypical multiple drug resistance in a human leukemic cell line selected for resistance to teniposide (VM-26).

1987 • 229 citations

Effect of antineoplastic agents on the DNA cleavage/religation reaction of eukaryotic topoisomerase II: inhibition of DNA religation by etoposide

1989 • 228 citations

Altered catalytic activity of and DNA cleavage by DNA topoisomerase II from human leukemic cells selected for resistance to VM-26

1988 • 223 citations

Inhibition of p34cdc2 kinase activity by etoposide or irradiation as a mechanism of G2 arrest in Chinese hamster ovary cells.

1990 • 222 citations

Phosphorylation of DNA topoisomerase II by casein kinase II: modulation of eukaryotic topoisomerase II activity in vitro.

1985 • 214 citations

The involvement of active DNA synthesis in camptothecin-induced G2 arrest: altered regulation of p34cdc2/cyclin B.

1992 • 209 citations

Pharmacological, molecular, and cytogenetic analysis of "atypical" multidrug-resistant human leukemic cells.

1987 • 180 citations

Characterization of an Amsacrine-resistant Line of Human Leukemia Cells

1989 • 179 citations

Correlations between intercalator-induced DNA strand breaks and sister chromatid exchanges, mutations, and cytotoxicity in Chinese hamster cells.

1985 • 174 citations

Non-P-glycoprotein-mediated multidrug resistance in a small cell lung cancer cell line: Evidence for decreased susceptibility to drug-induced DNA damage and reduced levels of topoisomerase II

1992 • 171 citations

Casein kinase II phosphorylates the eukaryote-specific C-terminal domain of topoisomerase II in vivo.

1992 • 170 citations

Newly replicated DNA is associated with DNA topoisomerase II in cultured rat prostatic adenocarcinoma cells

1986 • 168 citations

Topoisomerase II alpha and topoisomerase II beta genes: characterization and mapping to human chromosomes 17 and 3, respectively.

1992 • 166 citations

Characterization of acquired epipodophyllotoxin resistance in a Chinese hamster ovary cell line: loss of drug-stimulated DNA cleavage activity.

1986 • 165 citations

Expression of a mutant DNA topoisomerase II in CCRF-CEM human leukemic cells selected for resistance to teniposide.

1991 • 163 citations

In vitro and intracellular inhibition of topoisomerase II by the antitumor agent merbarone.

1989 • 159 citations

Non-P-glycoprotein mediated mechanism for multidrug resistance precedes P-glycoprotein expression during in vitro selection for doxorubicin resistance in a human lung cancer cell line

1991 • 156 citations

Identification of a point mutation in the topoisomerase II gene from a human leukemia cell line containing an amsacrine-resistant form of topoisomerase II.

1991 • 149 citations

Membrane vesicle formation due to acquired mitoxantrone resistance in human gastric carcinoma cell line EPG85-257.

1990 • 148 citations

Increased phosphorylation of DNA topoisomerase II in etoposide-resistant mutants of human cancer KB cells.

1991 • 146 citations

Combined modalities of resistance in etoposide-resistant human KB cell lines.

1988 • 146 citations

Multidrug resistance in mitoxantrone-selected HL-60 leukemia cells in the absence of P-glycoprotein overexpression.

1989 • 140 citations

Isolation of genetic suppressor elements, inducing resistance to topoisomerase II-interactive cytotoxic drugs, from human topoisomerase II cDNA.

1993 • 138 citations

Elevated expression of DNA topoisomerase II in camptothecin-resistant human tumor cell lines.

1990 • 133 citations

Inhibition of calf thymus type II DNA topoisomerase by poly(ADP-ribosylation).

1985 • 126 citations

Camptothecin-resistant mutants of Chinese hamster ovary cells containing a resistant form of topoisomerase I.

1988 • 125 citations

Mutagenic responses of thirteen anticancer drugs on mutation induction at multiple genetic loci and on sister chromatid exchanges in Chinese hamster ovary cells.

1983 • 117 citations

Mechanisms of Drug Resistance in Neoplastic Cells

1988 • 114 citations

In vivo phosphorylation of the 170-kDa form of eukaryotic DNA topoisomerase II

1989 • 112 citations

Monoclonal antibodies to human DNA topoisomerase I and the two isoforms of DNA topoisomerase II: 170- and 180-kDa isozymes

1992 • 110 citations

Cloning and characterization of the 5'-flanking region of the human topoisomerase II alpha gene.

1992 • 99 citations

The 180-kDa isoform of topoisomerase II is localized in the nucleolus and belongs to the structural elements of the nucleolar remnant

1992 • 98 citations

Phosphorylation of topoisomerase II by casein kinase II and protein kinase C: effects on enzyme-mediated DNA cleavage/religation and sensitivity to the antineoplastic drugs etoposide and 4'-(9-acridinylamino)methane-sulfon-m-anisidide.

1992 • 95 citations

The topoisomerase II inhibitor teniposide (VM-26) induces apoptosis in unstimulated mature murine lymphocytes

1992 • 95 citations

Two independent amsacrine-resistant human myeloid leukemia cell lines share an identical point mutation in the 170 kDa form of human topoisomerase II

1992 • 94 citations

Possible role for p34cdc2 kinase in etoposide-induced cell death of Chinese hamster ovary cells.

1990 • 91 citations

DNA topoisomerase I from calf thymus is inhibited in vitro by poly(ADP‐ribosylation)

1983 • 86 citations

Etoposide (VP-16-213)-induced gene alterations: potential contribution to cell death.

1991 • 85 citations

Single-strand conformational polymorphism analysis of the M(r) 170,000 isozyme of DNA topoisomerase II in human tumor cells.

1993 • 85 citations

Decreased nuclear matrix DNA topoisomerase II in human leukemia cells resistant to VM-26 and m-AMSA

1990 • 84 citations

Decreased DNA topoisomerase II in daunorubicin-resistant Ehrlich ascites tumor cells.

1991 • 78 citations

Drug resistance associated with altered DNA topoisomerase II

1993 • 76 citations

Elevated DNA topoisomerase II activity in nitrogen mustard-resistant human cells.

1987 • 75 citations

Characterization of a subline of P388 leukemia resistant to amsacrine: evidence of altered topoisomerase II function.

1987 • 73 citations

Mechanism of epipodophyllotoxin-induced cell death in poly(adenosine diphosphate-ribose) synthesis-deficient V79 Chinese hamster cell lines.

1990 • 73 citations

Mechanisms of resistance to drugs that inhibit DNA topoisomerases.

1991 • 72 citations

Sister chromatid exchanges, chromosomal aberrations, and cytotoxicity produced by antitumor topoisomerase II inhibitors in sensitive (DC3F) and resistant (DC3F/9-OHE) Chinese hamster cells.

1988 • 72 citations

Mechanisms of multidrug resistance in human tumor cells. The roles of P-glycoprotein, DNA topoisomerase II, and other factors

1990 • 70 citations

Molecular cloning and identification of a point mutation in the topoisomerase II cDNA from an etoposide-resistant Chinese hamster ovary cell line.

1993 • 68 citations

Teniposide-resistant CEM cells, which express mutant DNA topoisomerase II alpha, when treated with non-complex-stabilizing inhibitors of the enzyme, display no cross-resistance and reveal aberrant functions of the mutant enzyme.

1993 • 67 citations

Altered stability of etoposide-induced topoisomerase II-DNA complexes in resistant human leukaemia K562 cells

1994 • 67 citations

Molecular and Clinical Advances in Anticancer Drug Resistance

1991 • 66 citations

Phosphorylation of DNA topoisomerase II in a human tumor cell line.

1991 • 63 citations

Altered topoisomerase IIα in a drug-resistant small cell lung cancer cell line selected in VP-16

1994 • 61 citations

Camptothecin Hypersensitivity in PoIy(Adenosine Diphosphate-Ribose) Polymerase-Deficient Cell Lines

1989 • 59 citations

Expression of a mutant DNA topoisomerase II in CCRF-CEM human leukemic cells selected for resistance to teniposide

1991 • 53 citations

Altered gene expression in human leukemia K562 cells selected for resistance to etoposide

1993 • 52 citations

Reduced DNA topoisomerase II activity and drug-stimulated DNA cleavage in 9-hydroxyellipticine resistant cells

1988 • 49 citations

Evidence for a mutant allele of the gene for DNA topoisomerase II in adriamycin-resistant P388 murine leukemia cells.

1989 • 47 citations

Novel selection and genetic characterisation of an etoposide-resistant human leukaemic CCRF-CEM cell line

1993 • 46 citations

Increased ATP Requirement for Activity of and Complex Formation by DNA Topoisomerase II from Human Leukemic CCRF-CEM Cells Selected for Resistance to Teniposide

1989 • 45 citations

Differences between drug-sensitive and -resistant human leukemic CEM cells in c-jun expression, AP-1 DNA-binding activity, and formation of Jun/Fos family dimers, and their association with internucleosomal DNA ladders after treatment with VM-26.

1994 • 44 citations

Study of molecular markers of resistance to m-AMSA in a human breast cancer cell line

1991 • 43 citations

Cell cycle dependence of sister chromatid exchange induction by DNA topoisomerase II inhibitors in Chinese hamster V79 cells.

1987 • 42 citations

Yeast topoisomerase II mutants resistant to anti-topoisomerase agents: identification and characterization of new yeast topoisomerase II mutants selected for resistance to etoposide.

1994 • 41 citations

Hypersensitivity to Clinically Useful Alkylating Agents and Radiation in Poly(ADP-ribose) Polymerase-Deficient Cell Lines

1990 • 35 citations

Effects of antileukemia agents on nuclear matrix-bound DNA replication in CCRF-CEM leukemia cells.

1988 • 31 citations

DNA Repair in Radiation Sensitive Mutants of Mammalian Cells: Possible Involvement of DNA Topoisomerases

1990 • 29 citations

DNA topoisomerase II immunostaining in human leukemia and rhabdomyosarcoma cell lines and their responses to topoisomerase II inhibitors.

1992 • 23 citations

Altered DNA topoisomerase II in multidrug resistance

1993 • 21 citations

SEQUENCES OF INTEREST: Leucine Zipper in Human DNA Topoisomerase II

1989 • 21 citations

Effect of specific enzyme inhibitors on replication, total genome DNA repair and on gene-specific DNA repair after UV irradiation in CHO cells

1991 • 21 citations

Resistance to inhibitors of DNA topoisomerases

1991 • 21 citations

Alkylating Agent Hypersensitivity in Poly(Adenosine Diphosphate-Ribose) Polymerase Deficient Cell Lines

1991 • 20 citations

Characterization of an unusual mutant of human melanoma cells resistant to anticancer drugs that inhibit topoisomerase II

1993 • 20 citations

Development and characterization of a WEHI-3B D+ monomyelocytic leukemia cell line resistant to novobiocin and cross-resistant to other topoisomerase II-targeted drugs.

1992 • 13 citations

Different Mechanisms of Multiple Drug Resistance in Two Human Leukemic Cell Lines

1988 • 12 citations