Biochemical and pharmacological properties of p170 and p180 forms of topoisomerase II

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes.

1987 • 5,066 citations

Organization of the higher-order chromatin loop: specific DNA attachment sites on nuclear scaffold

1984 • 1,088 citations

Topoisomerase II is a structural component of mitotic chromosome scaffolds.

1985 • 751 citations

DNA topoisomerase II is required at the time of mitosis in yeast

1985 • 747 citations

Inhibition of membrane phosphotyrosyl-protein phosphatase activity by vanadate

1982 • 699 citations

DNA topoisomerase II mutant of Saccharomyces cerevisiae: topoisomerase II is required for segregation of daughter molecules at the termination of DNA replication.

1984 • 685 citations

Cleavage of DNA by mammalian DNA topoisomerase II.

1983 • 539 citations

Metaphase chromosome structure

1986 • 538 citations

Localization of topoisomerase II in mitotic chromosomes.

1985 • 501 citations

In situ localization of DNA topoisomerase II, a major polypeptide component of the Drosophila nuclear matrix fraction.

1985 • 472 citations

Role of topoisomerase II in mediating epipodophyllotoxin-induced DNA cleavage.

1984 • 463 citations

Topoisomerase II: A specific marker for cell proliferation.

1986 • 434 citations

Differential expression of DNA topoisomerases I and II during the eukaryotic cell cycle.

1988 • 415 citations

Isolation and characterization of the human Gs alpha gene.

1988 • 379 citations

DNA Topoisomerases: Enzymes That Control DNA Conformation

1985 • 337 citations

The organisation of chromatin loops: characterization of a scaffold attachment site

1986 • 308 citations

DNA topoisomerase II from Drosophila melanogaster. Relaxation of supercoiled DNA.

1983 • 302 citations

Mitotic spindle pulls but fails to separate chromosomes in type II DNA topoisomerase mutants: uncoordinated mitosis

1986 • 292 citations

Purification of topoisomerase II from amsacrine-resistant P388 leukemia cells. Evidence for two forms of the enzyme.

1987 • 282 citations

Mechanistic Aspects of DNA Topoisomerases

1986 • 260 citations

Proliferation-dependent regulation of DNA topoisomerase II in cultured human cells.

1988 • 244 citations

Novel topologically knotted DNA from bacteriophage P4 capsids: studies with DNA topoisomerases

1981 • 231 citations

Eukaryotic topoisomerase II. Characterization of enzyme turnover.

1986 • 213 citations

Phosphotyrosyl-protein phosphatase of TCRC-2 cells.

1982 • 195 citations

The ease of DNA unwinding as a determinant of initiation at yeast replication origins

1988 • 193 citations

Illegitimate recombination mediated by calf thymus DNA topoisomerase II in vitro.

1988 • 168 citations

Newly replicated DNA is associated with DNA topoisomerase II in cultured rat prostatic adenocarcinoma cells

1986 • 168 citations

In vitro and intracellular inhibition of topoisomerase II by the antitumor agent merbarone.

1989 • 159 citations

Proliferation-dependent topoisomerase II content as a determinant of antineoplastic drug action in human, mouse, and Chinese hamster ovary cells.

1987 • 147 citations

Topoisomerase-specific drug sensitivity in relation to cell cycle progression.

1987 • 144 citations

DNA topoisomerase II: A primer on the enzyme and its unique role as a multidrug target in cancer chemotherapy

1987 • 139 citations

Tandem Regions of Yeast DNA Topoisomerase II Share Homology with Different Subunits of Bacterial Gyrase

1986 • 124 citations

Base composition of ribosomal RNA precursors in the HeLa cell nucleolus: Further evidence of non-conservative processing

1968 • 115 citations

Mature mRNA is selectively released from the nuclear matrix by an ATP/dATP-dependent mechanism sensitive to topoisomerase inhibitors.

1987 • 73 citations

In vitro transcription of eukaryotic genes is affected differently by the degree of DNA supercoiling.

1988 • 73 citations

Characterization of a subline of P388 leukemia resistant to amsacrine: evidence of altered topoisomerase II function.

1987 • 73 citations

Sister chromatid exchanges, chromosomal aberrations, and cytotoxicity produced by antitumor topoisomerase II inhibitors in sensitive (DC3F) and resistant (DC3F/9-OHE) Chinese hamster cells.

1988 • 72 citations

Gyration is required for 5S RNA transcription from a chromatin template.

1986 • 51 citations

Expression of the Drosophila type II topoisomerase is developmentally regulated

1988 • 43 citations

Altered expression and transcription of the topoisomerase II gene in nitrogen mustard-resistant human cells

1988 • 26 citations

Pattern of recognition of DNA by mammalian DNA topoisomerase II

1988 • 9 citations

Role for topoisomerases in the release of DNA into the detergent-soluble fraction of eukaryotic cells.

1986 • 7 citations