The 180-kDa isoform of topoisomerase II is localized in the nucleolus and belongs to the structural elements of the nucleolar remnant

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

DNA TOPOISOMERASES

1985 • 1,524 citations

Chromosomal loop anchorage of the kappa immunoglobulin gene occurs next to the enhancer in a region containing topoisomerase II sites

1986 • 922 citations

Topoisomerase II is a structural component of mitotic chromosome scaffolds.

1985 • 751 citations

A fixed site of DNA replication in eucaryotic cells

1980 • 669 citations

Cohabitation of scaffold binding regions with upstream/enhancer elements of three developmentally regulated genes of D. melanogaster

1986 • 587 citations

Localization of topoisomerase II in mitotic chromosomes.

1985 • 501 citations

Biochemical and pharmacological properties of p170 and p180 forms of topoisomerase II

1989 • 409 citations

Dynamic association of replicating DNA fragments with the nuclear matrix of regenerating liver

1981 • 229 citations

Newly replicated DNA is associated with DNA topoisomerase II in cultured rat prostatic adenocarcinoma cells

1986 • 168 citations

Protein kinase NII and the regulation of rDNA transcription in mammalian cells

1989 • 115 citations

Base composition of ribosomal RNA precursors in the HeLa cell nucleolus: Further evidence of non-conservative processing

1968 • 115 citations

Spatial distribution of DNA loop attachment and replicational sites in the nuclear matrix.

1984 • 113 citations

Monoclonal antibodies to human DNA topoisomerase I and the two isoforms of DNA topoisomerase II: 170- and 180-kDa isozymes

1992 • 110 citations

Does the synthesis of ribosomal RNA take place‐within nucleolar fibrillar centers or dense fibrillar components?

1989 • 110 citations

Heat shock-induced changes in the structural stability of proteinaceous karyoskeletal elements in vitro and morphological effects in situ.

1987 • 88 citations

Essential roles of the RNA polymerase I largest subunit and DNA topoisomerases in the formation of fission yeast nucleolus.

1989 • 84 citations

DNA interactions with the nuclear matrix and spatial organization of replication and transcription

1987 • 78 citations

Attachment of origins of replication to the nuclear matrix and the chromosomal scaffold

1984 • 72 citations

Does the synthesis of ribosomal RNA take place-within nucleolar fibrillar centers or dense fibrillar components?

1989 • 66 citations

Association of topoisomerase II with the hepatoma cell nuclear matrix: The role of intermolecular disulfide bond formation

1991 • 60 citations

Characterization of a heat shock-induced insoluble complex in the nuclei of cells

1987 • 54 citations

Multiple forms and cellular localization of Drosophila DNA topoisomerase II.

1986 • 46 citations

Heat Shock-induced Appearance of RNA Polymerase II in Karyoskeletal Protein-enriched (Nuclear “Matrix”) Fractions Correlates with Transcriptional Shutdown in Drosophila melanogaster

1989 • 43 citations

Nuclear matrix-bound DNA primase. Elucidation of an RNA priming system in nuclear matrix isolated from regenerating rat liver.

1987 • 30 citations

Cytochemical localization of DNA loop attachment sites to the nuclear lamina and to the inner nuclear matrix

1989 • 16 citations