Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages
Data up to Jan 2025
Total Citations Per Year
Abstract
References (31)
NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses
1998 • 5,178 citations
An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death
1996 • 3,094 citations
IL-10 inhibits cytokine production by activated macrophages.
1991 • 2,919 citations
Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB
1995 • 1,849 citations
Activation of interleukin-6 gene expression through the NF-kappa B transcription factor.
1990 • 1,377 citations
THE INTERLEUKIN-12/INTERLEUKIN-12-RECEPTOR SYSTEM: Role in Normal and Pathologic Immune Responses
1998 • 1,253 citations
Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses
1995 • 1,184 citations
Regulation of tumor necrosis factor alpha transcription in macrophages: involvement of four kappa B-like motifs and of constitutive and inducible forms of NF-kappa B.
1990 • 900 citations
Endotoxin signal transduction in macrophages
1996 • 803 citations
Interleukin-12: A Cytokine at the Interface of Inflammation and Immunity
1998 • 785 citations
Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression.
1995 • 740 citations
The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells.
1996 • 663 citations
Characterization of a functional NF-kappa B site in the human interleukin 1 beta promoter: evidence for a positive autoregulatory loop.
1993 • 600 citations
Relish, a Central Factor in the Control of Humoral but Not Cellular Immunity in Drosophila
1999 • 511 citations
Selection of Optimal κB/Rel DNA-Binding Motifs: Interaction of Both Subunits of NF-κB with DNA Is Required for Transcriptional Activation
1992 • 501 citations
Regulation of Interleukin 12 p40 Expression through an NF-κB Half-Site
1995 • 495 citations
Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis
1999 • 410 citations
Molecular Mechanisms of the Induction of IL-12 and Its Inhibition by IL-10
1998 • 397 citations
Activation of Interleukin-6 Gene Expression through the NF-κB Transcription Factor
1990 • 379 citations
The Rel Protein DIF Mediates the Antifungal but Not the Antibacterial Host Defense in Drosophila
2000 • 353 citations
Multiple Control Elements Mediate Activation of the Murine and Human Interleukin 12 p40 Promoters: Evidence of Functional Synergy between C/EBP and Rel Proteins
1997 • 310 citations
Regulation of Tumor Necrosis Factor Alpha Transcription in Macrophages: Involvement of Four κΒ-Like Motifs and of Constitutive and Inducible Forms of NF-κB
1990 • 230 citations
Rel Induces Interferon Regulatory Factor 4 (IRF-4) Expression in Lymphocytes
2000 • 193 citations
Rapid and Selective Remodeling of a Positioned Nucleosome during the Induction of IL-12 p40 Transcription
1999 • 184 citations
Differential regulation of interleukin-12 (IL-12), tumor necrosis factor alpha, and IL-1 beta production in human myeloid leukemia cell lines and peripheral blood mononuclear cells
1994 • 182 citations
Characterization of a Functional NF-κB Site in the Human Interleukin 1β Promoter: Evidence for a Positive Autoregulatory Loop
1993 • 156 citations
Rel-deficient T cells exhibit defects in production of interleukin 3 and granulocyte-macrophage colony-stimulating factor.
1996 • 147 citations
c-Rel is essential for B lymphocyte survival and cell cycle progression
1998 • 131 citations
The Rel subunit of NF-kappaB-like transcription factors is a positive and negative regulator of macrophage gene expression: distinct roles for Rel in different macrophage populations.
1996 • 120 citations
Pillars Article: IL-10 Inhibits Cytokine Production by Activated Macrophages. J. Immunol. 1991. 147: 3815-3822.
2016 • 52 citations
The taming of IL-12: suppressing the production of proinflammatory cytokines
1999 • 40 citations