Use of adoptive transfer of T‐cell antigen‐receptor‐transgenic T cells for the study of T‐cell activation in vivo

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

CD28/B7 SYSTEM OF T CELL COSTIMULATION

1996 • 2,726 citations

Interleukin-12: A Proinflammatory Cytokine with Immunoregulatory Functions that Bridge Innate Resistance and Antigen-Specific Adaptive Immunity

1995 • 2,437 citations

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

1996 • 2,032 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Acquisition of Lymphokine-Producing Phenotype by CD4+ T Cells

1994 • 1,573 citations

Traffic Signals on Endothelium for Lymphocyte Recirculation and Leukocyte Emigration

1995 • 1,525 citations

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

The Role of the CD28 Receptor During T Cell Responses to Antigen

1993 • 1,320 citations

Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo

1994 • 967 citations

Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity

1990 • 904 citations

Fundamental Immunology

1994 • 903 citations

The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody.

1983 • 861 citations

Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo.

1996 • 800 citations

Programmed cell death and extrathymic reduction of Vβ8+CD4+ T cells in mice tolerant to Staphylococcus aureus enterotoxin B

1991 • 675 citations

The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro.

1994 • 607 citations

T cell-mediated lethal shock triggered in mice by the superantigen staphylococcal enterotoxin B: critical role of tumor necrosis factor.

1992 • 595 citations

B Cells Turn Off Virgin But Not Memory T Cells

1992 • 578 citations

The Role of Protein Tyrosine Kinases and Protein Tyrosine Phosphatases in T Cell Antigen Receptor Signal Transduction

1994 • 519 citations

Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand

1995 • 476 citations

Dendritic cell loss from nonlymphoid tissues after systemic administration of lipopolysaccharide, tumor necrosis factor, and interleukin 1.

1995 • 472 citations

Antigen-Specific Development of Primary and Memory T Cells in Vivo

1995 • 444 citations

Requirement for CD40 Ligand in Costimulation Induction, T Cell Activation, and Experimental Allergic Encephalomyelitis

1996 • 425 citations

CD40 Ligand-Dependent T Cell Activation: Requirement of B7-CD28 Signaling Through CD40

1996 • 421 citations

A T cell receptor Vβ segment that imparts reactivity to a class II major histocompatibility complex product

1987 • 408 citations

Kinetic Differences in Unresponsiveness of Thymus and Bone Marrow Cells

1971 • 374 citations

CD40 Ligand Is Required for Protective Cell-Mediated Immunity to Leishmania major

1996 • 332 citations

Dendritic cells can present antigen in vivo in a tolerogenic or immunogenic fashion.

1996 • 330 citations

Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4.

1995 • 323 citations

Selective anergy of V beta 8+,CD4+ T cells in Staphylococcus enterotoxin B-primed mice.

1990 • 312 citations

Sensitization and Antibody Formation after Injection of Tubercle Bacilli and Paraffin Oil.

1937 • 311 citations

Functional expression of the costimulatory molecule, B7/BB1, on murine dendritic cell populations.

1992 • 306 citations

Successful T cell priming in B cell-deficient mice.

1995 • 284 citations

T cell immunity after a viral infection versus T cell tolerance induced by soluble viral peptides

1993 • 256 citations

Tumour necrosis factor-alpha is required for accumulation of dendritic cells in draining lymph nodes and for optimal contact sensitization.

1995 • 246 citations

Functional and ontogenetic analysis of murine CD45Rhi and CD45Rlo CD4+ T cells.

1990 • 236 citations

Interleukin 1 enhances T-dependent immune responses by amplifying the function of dendritic cells.

1987 • 215 citations

Selection of Amino Acid Sequences in the Beta Chain of the T Cell Antigen Receptor

1988 • 203 citations

Sophisticated strategies for information encounter in the lymph node: the reticular network as a conduit of soluble information and a highway for cell traffic.

1996 • 192 citations

Interleukin 12: A key modulator of immune function

1994 • 190 citations

Human dendritic cells activate T lymphocytes via a CD40: CD40 ligand‐dependent pathway

1996 • 149 citations

Effectiveness of Lipid and Lipidophilic Substances as Adjuvants

1961 • 148 citations

Microbial induction of co-stimulatory activity for CD4 T-cell growth

1991 • 130 citations

Direct measurement of anergy of antigen-specific T cells following oral tolerance induction.

1996 • 118 citations

Sequential antigen‐specific growth of T cells in the T zones and follicles in response to pigeon cytochrome c

1996 • 116 citations

T cells within germinal centers are specific for the immunizing antigen.

1993 • 110 citations

Peptide-specific T cell clonal expansion in vivo following immunization in the eye, an immune-privileged site.

1996 • 106 citations

In vivo activation of naive T cells by antigen-presenting B cells.

1994 • 95 citations

Surface proteins involved in T cell costimulation

1994 • 92 citations

Memory T cell development in the absence of specific antigen priming.

1996 • 83 citations

Parameters of tolerance induction by antigen targeted to B lymphocytes.

1993 • 73 citations

B cells are not essential for peripheral T-cell tolerance.

1996 • 65 citations

Coexpression of B7-1 and antigen blocks tolerance induction to antigen presented by resting B cells.

1996 • 29 citations

Superantigen-induced peripheral tolerance inhibits T cell responses to immunogenic peptides in TCR (beta-chain) transgenic mice.

1993 • 26 citations

Follicular Dendritic Cells in Germinal Center Reactions

1993 • 23 citations

Current perspectives on the cellular mechanisms of immunologic tolerance.

1980 • 20 citations