The evolution of self-tolerance: a new cell arises to meet the challenge of self-reactivity

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

1997 • 5,522 citations

Tolerance, Danger, and the Extended Family

1994 • 4,654 citations

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

1992 • 3,751 citations

The clonal selection theory of acquired immunity

1959 • 2,008 citations

A Theory of Self-Nonself Discrimination

1970 • 1,700 citations

Innate immunity: impact on the adaptive immune response

1997 • 1,542 citations

The immune system evolved to discriminate infectious nonself from noninfectious self

1992 • 1,324 citations

The Enigmatic Plasmacytoid T Cells Develop into Dendritic Cells with Interleukin (IL)-3 and CD40-Ligand

1997 • 1,224 citations

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

The Specificity of Serological Reactions

1945 • 1,104 citations

The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing

1995 • 959 citations

Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo.

1996 • 800 citations

Genetic Analysis of Autoimmune Disease

1996 • 739 citations

Human T, B, natural killer, and dendritic cells arise from a common bone marrow progenitor cell subset

1995 • 687 citations

Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population

1993 • 673 citations

Dendritic cells pulsed with protein antigens in vitro can prime antigen-specific, MHC-restricted T cells in situ.

1990 • 670 citations

A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis.

1996 • 653 citations

Constitutive class I-restricted exogenous presentation of self antigens in vivo.

1996 • 637 citations

Macrophages ingest and are activated by bacterial DNA.

1996 • 579 citations

Models of T cell anergy: is there a common molecular mechanism?

1996 • 575 citations

When Two Strands Are Better Than One: The Mediators and Modulators of the Cellular Responses to Double-Stranded RNA

1996 • 574 citations

Dendritic cells in the T‐cell areas of lymphoid organs

1997 • 572 citations

A NEW ANALYSIS OF ALLOGENEIC INTERACTIONS

1975 • 551 citations

New perspectives of C1328-137-mediated T cell costimulation

1995 • 526 citations

The production of antibodies

1949 • 526 citations

Dendritic cell subtypes in mouse lymphoid organs: cross-correlation of surface markers, changes with incubation, and differences among thymus, spleen, and lymph nodes.

1997 • 524 citations

Langerhans' cells, veiled cells, and interdigitating cells in the mouse recognized by a monoclonal antibody.

1986 • 478 citations

Dendritic cell loss from nonlymphoid tissues after systemic administration of lipopolysaccharide, tumor necrosis factor, and interleukin 1.

1995 • 472 citations

Low avidity recognition of self-antigen by T cells permits escape from central tolerance

1995 • 415 citations

Thymic dendritic cell precursors: relationship to the T lymphocyte lineage and phenotype of the dendritic cell progeny.

1996 • 405 citations

Spontaneous recovery of rats from experimental allergic encephalomyelitis is dependent on regulation of the immune system by endogenous adrenal corticosteroids.

1989 • 339 citations

Dendritic cells: from ontogenetic orphans to myelomonocytic descendants

1996 • 324 citations

High Levels of a Major Histocompatibility Complex II–Self Peptide Complex on Dendritic Cells from the T Cell Areas of Lymph Nodes

1997 • 292 citations

Does T-cell tolerance require a dedicated antigen-presenting cell?

1989 • 288 citations

IMMUNITY IN INFECTIVE DISEASES

1906 • 282 citations

Microglia induce CD4 T lymphocyte final effector function and death.

1996 • 266 citations

Dendritic Cell Development in Culture from Thymic Precursor Cells in the Absence of Granulocyte/Macrophage Colony-stimulating Factor

1996 • 265 citations

Heterogeneity of Mouse Spleen Dendritic Cells: In Vivo Phagocytic Activity, Expression of Macrophage Markers, and Subpopulation Turnover

1998 • 261 citations

Analysis of Autoimmunity through Experimental Models of Thyroiditis and Allergic Encephalomyelitis

1980 • 253 citations

The fate of self-reactive B cells depends primarily on the degree of antigen receptor engagement and availability of T cell help.

1996 • 251 citations

Lipopolysaccharide interferes with the induction of peripheral T cell death

1995 • 240 citations

Induction of hapten-specific tolerance by interleukin 10 in vivo.

1994 • 232 citations

Migration patterns of dendritic cells in the mouse. Homing to T cell-dependent areas of spleen, and binding within marginal zone.

1988 • 226 citations

Fluids from immune privileged sites endow macrophages with the capacity to induce antigen‐specific immune deviation via a mechanism involving transforming growth factor‐β

1992 • 206 citations

The anatomy of peripheral lymphoid organs with emphasis on accessory cells: Light‐microscopic immunocytochemical studies of mouse spleen, lymph node, and peyer's patch

1984 • 188 citations

Fc chimeric protein containing the cysteine-rich domain of the murine mannose receptor binds to macrophages from splenic marginal zone and lymph node subcapsular sinus and to germinal centers.

1996 • 156 citations

Peripheral deletion of autoreactive CD8⁺ T cells in transgenic mice expressing H‐2K^b in the liver

1995 • 138 citations

Immunological Tolerance of Nonliving Antigens

1961 • 136 citations

Experimental Allergic Encephalomyelitis in the Lewis Rat: Studies on the Mechanism of Recovery from Disease and Acquired Resistance to Reinduction

1979 • 134 citations

Three populations of mouse lymph node dendritic cells with different origins and dynamics

1997 • 133 citations

THE ANTIBODY RESPONSE TO BACTERIOPHAGE ϕX 174 IN NEWBORN PREMATURE INFANTS*

1962 • 124 citations

Proliferation is a prerequisite for bacterial superantigen-induced T cell apoptosis in vivo.

1995 • 123 citations

Specialized antigen-presenting cells. Splenic dendritic cells and peritoneal-exudate cells induced by mycobacteria activate effector T cells that are resistant to suppression.

1982 • 109 citations

Regulation of immune response to inhaled antigen by alveolar macrophages: differential effects of in vivo alveolar macrophage elimination on the induction of tolerance vs. immunity

1991 • 105 citations

Three Populations of Mouse Lymph Node Dendritic Cells with Different Origins and Dynamics

1998 • 99 citations

The Specificity of Serological Reactions

1936 • 86 citations

The Production of Antibodies

1950 • 78 citations

Induction of unresponsiveness and impaired T cell expansion by staphylococcal enterotoxin B in CD28-deficient mice.

1996 • 78 citations

Tolerance sensitivity of immature-stage B cells: can developmentally regulated B cell antigen receptor (BCR) signal transduction play a role?

1996 • 70 citations

IMMUNITY IN INFECTIVE DISEASES

1906 • 69 citations

Abolition of specific immune response defect by immunization with dendritic cells

1985 • 68 citations

Role of Hemocyte‐Derived Granular Components in Invertebrate Defense^a

1994 • 46 citations

Invertebrate cytokines: The phylogenetic emergence of interleukin‐1

1989 • 44 citations

Multiple sites of post‐activation CD8⁺ T cell disposal

1997 • 44 citations

Rescue of self-reactive B cells by provision of T cell helpin vivo

1998 • 43 citations

The nature of the signals regulating CD8 T cell proliferative responses to CD8α⁺ or CD8α⁻ dendritic cells

1997 • 42 citations

THE IMMUNOLOGICAL RESPONSE OF FOETAL MICE TO INFLUENZA VIRUS

1957 • 40 citations

Development of an Immune System^a

1994 • 27 citations

Phagocytosis and Invertebrate Opsonins in Relation to Parasitism^a

1994 • 22 citations

THE COMPARATIVE SUSCEPTIBILITY OF FETAL AND POSTNATAL GUINEA PIGS TO THE VIRUS OF EPIDEMIC INFLUENZA

1940 • 17 citations

Role of Dendritic Cells in Induction of Tolerance and Immunity in Vivo

1997 • 8 citations

Regulation of the immune response – lessons from transgenic models

1995 • 7 citations