Angiogenesis and Cancer Control: From Concept to Therapeutic Trial

Tumor Angiogenesis: Therapeutic Implications

1971 • 9,898 citations

Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth

1997 • 4,504 citations

Angiogenic Factors

1987 • 3,702 citations

Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis

1997 • 3,470 citations

Thalidomide is an inhibitor of angiogenesis.

1994 • 2,460 citations

Clinical Applications of Research on Angiogenesis

1995 • 2,300 citations

Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression

1995 • 1,863 citations

Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance

1997 • 1,705 citations

Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth

1990 • 1,308 citations

Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal

1999 • 1,248 citations

Angiostatin induces and sustains dormancy of human primary tumors in mice

1996 • 1,193 citations

Copper biochemistry and molecular biology

1996 • 1,171 citations

Anti-Angiogenesis

1972 • 1,167 citations

SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types.

1999 • 1,044 citations

Effects of Angiogenesis Inhibitors on Multistage Carcinogenesis in Mice

1999 • 990 citations

Detection of tumor angiogenesis in vivo by αvβ3-targeted magnetic resonance imaging

1998 • 851 citations

Increased Vascularization in Mice Overexpressing Angiopoietin-1

1998 • 818 citations

Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis.

1995 • 766 citations

Inhibition of Angiogenesis In Vivo by Interleukin 12

1995 • 734 citations

Combined effects of angiostatin and ionizing radiation in antitumour therapy

1998 • 679 citations

Vascular endothelial growth factor is essential for corpus luteum angiogenesis

1998 • 641 citations

Identification of endothelin–1 in the pathophysiology of metastatic adenocarcinoma of the prostate

1995 • 627 citations

Expression of vascular endothelial growth factor and its receptors in hematopoietic malignancies.

1999 • 543 citations

Angiostatin binds ATP synthase on the surface of human endothelial cells

1999 • 520 citations

Molecular insights into cancer invasion: strategies for prevention and intervention.

1995 • 500 citations

Oncogenic H-ras stimulates tumor angiogenesis by two distinct pathways

1997 • 470 citations

Interleukin-12 and interleukin-18 synergistically induce murine tumor regression which involves inhibition of angiogenesis.

1998 • 419 citations

Tumor Angiogenesis: A Quantitative Method for Histologic Grading<xref ref-type="fn" rid="FN2">2</xref>

1972 • 418 citations

Matrix Metalloproteinase Inhibition as a Novel Anticancer Strategy: A Review with Special Focus on Batimastat and Marimastat

1997 • 403 citations

Copper stimulates proliferation of human endothelial cells under culture

1998 • 398 citations

Role of prostaglandin E1 and copper in angiogenesis.

1982 • 393 citations

Angiostatin induces endothelial cell apoptosis and activation of focal adhesion kinase independently of the integrin-binding motif RGD

1998 • 349 citations

Antiangiogenic therapy of transgenic mice impairs de novo tumor growth.

1996 • 349 citations

NMR imaging of changes in vascular morphology due to tumor angiogenesis

1998 • 342 citations

Captopril inhibits angiogenesis and slows the growth of experimental tumors in rats.

1996 • 327 citations

Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells

1994 • 315 citations

Systemic inhibition of tumor growth and tumor metastases by intramuscular administration of the endostatin gene

1999 • 301 citations

Levels of vascular endothelial growth factor, hepatocyte growth factor/scatter factor and basic fibroblast growth factor in human gliomas and their relation to angiogenesis

1999 • 296 citations

The mechanism of cancer-mediated conversion of plasminogen to the angiogenesis inhibitor angiostatin

1997 • 292 citations

Vascular integrin alpha(v)beta3: a new prognostic indicator in breast cancer.

1998 • 281 citations

Impact of oncogenes in tumor angiogenesis: Mutant K- ras up-regulation of vascular endothelial growth factor/vascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells

1998 • 264 citations

Increased capillary endothelial cell protease activity in response to angiogenic stimuli in vitro.

1983 • 261 citations

Expression of angiostatin cDNA in a murine fibrosarcoma suppresses primary tumor growth and produces long-term dormancy of metastases.

1998 • 254 citations

Antiangiogenic Therapy of a Recurrent Giant Cell Tumor of the Mandible With Interferon Alfa-2a

1999 • 245 citations

Adenovirus-mediated wild-type p53 gene transfer down-regulates vascular endothelial growth factor expression and inhibits angiogenesis in human colon cancer.

1998 • 242 citations

Potentiation of cytotoxic cancer therapies by TNP‐470 alone and with other anti‐angiogenic agents

1994 • 241 citations

Integrin alpha(v)beta3 promotes M21 melanoma growth in human skin by regulating tumor cell survival.

1999 • 238 citations

Microvessel count and cerebrospinal fluid basic fibroblast growth factor in children with brain tumours

1994 • 234 citations

Multiple Forms of Angiostatin Induce Apoptosis in Endothelial Cells

1998 • 231 citations

Inhibition of angiogenesis and tumor growth in the brain. Suppression of endothelial cell turnover by penicillamine and the depletion of copper, an angiogenic cofactor.

1990 • 230 citations

Troponin I is present in human cartilage and inhibits angiogenesis

1999 • 221 citations

Sequential development of an angiogenic phenotype by human fibroblasts progressing to tumorigenicity

1997 • 217 citations

Expression of endothelin 1 and endothelin A receptor in ovarian carcinoma: evidence for an autocrine role in tumor growth.

1999 • 205 citations

Vascular endothelial growth factor expression and vascular density as prognostic markers of survival in patients with low-grade astrocytoma

1998 • 204 citations

Potentiation of the antitumor effect of ionizing radiation by brief concomitant exposures to angiostatin.

1998 • 201 citations

Angiogenesis as a marker of preneoplastic lesions of the human breast

1978 • 199 citations

A recombinant human angiostatin protein inhibits experimental primary and metastatic cancer.

1997 • 197 citations

Angiostatin suppresses malignant glioma growth in vivo.

1998 • 189 citations

Prolonged tumor dormancy by prevention of neovascularization in the vitreous.

1976 • 176 citations

Viral vector-targeted antiangiogenic gene therapy utilizing an angiostatin complementary DNA.

1998 • 173 citations

Quantitative analysis of copper, zinc and copper/zinc ratio in selected human brain tumors

1993 • 168 citations

Squalamine inhibits angiogenesis and solid tumor growth in vivo and perturbs embryonic vasculature.

1998 • 165 citations

Angiogenesis Activators and Inhibitors Differentially Regulate Caveolin-1 Expression and Caveolae Formation in Vascular Endothelial Cells

1999 • 163 citations

Angiogenesis: A Marker for Neoplastic Transformation of Mammary Papillary Hyperplasia

1977 • 161 citations

Endothelial cell phagokinesis in response to specific metal ions

1980 • 158 citations

Bone marrow angiogenesis in patients achieving complete response after stem cell transplantation for multiple myeloma

1999 • 156 citations

Induction of apoptosis in proliferating human endothelial cells by the tumor-specific antiangiogenesis agent combretastatin A-4.

1998 • 154 citations

Establishing a Link between Oncogenes and Tumor Angiogenesis

1998 • 148 citations

Immune events associated with the cure of established tumors and spontaneous metastases by local and systemic interleukin 12.

1999 • 141 citations

Antiangiogenesis treatment for gliomas: transfer of antisense-vascular endothelial growth factor inhibits tumor growth in vivo.

1999 • 140 citations

Marked inhibition of tumor growth in a malignant glioma tumor model by a novel synthetic matrix metalloproteinase inhibitor AG3340.

1999 • 136 citations

Targeting the tumor vasculature with combretastatin A-4 disodium phosphate: effects on radiation therapy

1998 • 135 citations

Fumagillin analog in the treatment of Kaposi's sarcoma: a phase I AIDS Clinical Trial Group study. AIDS Clinical Trial Group No. 215 Team.

1998 • 134 citations

Marimastat (BB2516): Current status of development

1999 • 131 citations

A phase I study of TNP-470 administered to patients with advanced squamous cell cancer of the cervix.

1997 • 131 citations

Suramin, an anticancer and angiosuppressive agent, inhibits endothelial cell binding of basic fibroblast growth factor, migration, proliferation, and induction of urokinase-type plasminogen activator.

1994 • 130 citations

Serum trace elements and Cu/Zn ratio in breast cancer patients

1991 • 128 citations

Adenovirus-mediated delivery of a uPA/uPAR antagonist suppresses angiogenesis-dependent tumor growth and dissemination in mice

1998 • 126 citations

Inhibition of human endothelial cell proliferation in vitro and neovascularization in vivo by D-penicillamine.

1989 • 123 citations

The Role of Vascular Proliferation in the Growth of Brain Tumors

1976 • 118 citations

Phase II Evaluation of Thalidomide in Patients With Metastatic Breast Cancer

2000 • 117 citations

Zinc-Binding of Endostatin Is Essential for Its Antiangiogenic Activity

1998 • 117 citations

Serum and tissue trace elements in colorectal cancer

1993 • 114 citations

Marimastat in Patients With Advanced Pancreatic Cancer

1999 • 112 citations

Inhibition of gelatinase A (MMP-2) by batimastat and captopril reduces tumor growth and lung metastases in mice bearing Lewis lung carcinoma

1999 • 112 citations

MRI Enhancement and Microvascular Density in Gliomas

1999 • 112 citations

Clinical investigation of a cytostatic calcium influx inhibitor in patients with refractory cancers.

1996 • 110 citations

Angiostatin inhibits endothelial and melanoma cellular invasion by blocking matrix-enhanced plasminogen activation

1999 • 110 citations

Correlation of Endothelin-1 and Transforming Growth Factor β1 with Malignancy and Vascularity in Human Gliomas

1997 • 109 citations

Use of the copper/zinc ratio in the diagnosis of lung cancer

1989 • 108 citations

Angiogenic factors are hematopoietic growth factors and vice versa.

1994 • 108 citations

Immunolocalization of basic fibroblast growth factor to the micro vasculature of human brain tumors

1992 • 100 citations

Semiquantitative Epstein-Barr Virus Polymerase Chain Reaction Analysis of Peripheral Blood From Organ Transplant Patients and Risk for the Development of Lymphoproliferative Disease

1998 • 99 citations

Raised endothelin 1 levels in patients with colorectal liver metastases

1998 • 95 citations

Antiangiogenic agents can increase tumor oxygenation and response to radiation therapy

1994 • 94 citations

Medicine and the Nature of Vertical Reasoning

1988 • 90 citations

Elevated levels of urokinase-type plasminogen activator and plasminogen activator inhibitor type-1 in malignant human brain tumors.

1994 • 86 citations

Antiangiogenic Gene Therapy in a Rat Glioma Model Using a Dominant-Negative Vascular Endothelial Growth Factor Receptor 2

1999 • 84 citations

Mutant p53 Correlates with Reduced Expression of Thrombospondin-1, Increased Angiogenesis, and Metastatic Progression in Melanoma

1998 • 83 citations

Serum ceruloplasmin and copper levels in patients with primary brain tumors

1984 • 82 citations

Serum ceruloplasmin as a diagnostic marker of cancer

1997 • 81 citations

Phase I trial of micronized formulation carboxyamidotriazole in patients with refractory solid tumors: pharmacokinetics, clinical outcome, and comparison of formulations.

1997 • 79 citations

Altered distribution of copper (64Cu) in tumor-bearing mice and rats.

1986 • 76 citations

Inhibitors of Angiogenesis Enter Phase III Testing

1998 • 75 citations

Anticopper treatment inhibits pseudopodial protrusion and the invasive spread of 9L gliosarcoma cells in the rat brain

1990 • 75 citations

Markers of tumor angiogenesis: clinical applications in prognosis and anti-angiogenic therapy

1997 • 71 citations

The Pharmacokinetics of TNP‐470, a New Angiogenesis Inhibitor

1997 • 62 citations

Angiogenesis and blood-brain barrier breakdown modulate CT contrast enhancement: an experimental study in a rabbit brain-tumor model

1989 • 60 citations

Cancer risk in relation to serum copper levels.

1989 • 60 citations

Anticopper Treatment Inhibits Pseudopodial Protrusion and the Invasive Spread of 9L Gliosarcoma Cells in the Rat Brain

1990 • 59 citations

p53 induces angiogenesis-restricted dormancy in a mouse fibrosarcoma

1998 • 54 citations

Protamine inhibits angiogenesis and growth of C6 rat glioma; a synergistic effect when combined with carmustine

1998 • 45 citations

Inhibition of Tumor Angiogenesis^a

1994 • 45 citations

Considerations on the mechanism of the angiogenic response.

1986 • 44 citations

Phase I study of the antineovascularization drug CM101.

1997 • 42 citations

Are angiostatin and endostatin cures for cancer?

1998 • 39 citations

OncogenicrasFails to Restore anin VivoTumorigenic Phenotype in Embryonic Stem Cells Lacking Vascular Endothelial Growth Factor (VEGF)

1999 • 38 citations

The Power of the Front Page of The New York Times

1998 • 34 citations

Targeting in Gene Therapy for Gliomas

1999 • 34 citations

A novel approach to glioma gene therapy: down-regulation of the vascular endothelial growth factor in glioma cells using ribozymes.

1998 • 33 citations

Role of Vascular Endothelial Growth Factor in Regulation of Angiogenesis

1999 • 30 citations

Perfusion Magnetic Resonance Imaging to Assess Brain Tumor Responses to New Therapies

1998 • 29 citations

Suppression of 9L gliosarcoma growth by copper depletion with copper-deficient diet and D-Penicillamine

1993 • 27 citations

Ceruloplasmin as a marker of neoplastic activity in rabbits bearing the VX-2 carcinoma.

1978 • 26 citations

Gene transfer technologies for malignant gliomas

1999 • 25 citations

Angiogenesis antagonists: current clinical trials.

1998 • 21 citations

Review of circulating tumor markers: from enzyme, carcinoembryonic protein to oncogene and suppressor gene.

1999 • 19 citations

Fluctuation of Zinc, Copper, Magnesium and Calcium Concentrations in Guinea Pig Tissues after Administration of Captopril (SQ 14225)

1997 • 18 citations

Cytostatic Agents in the Management of Malignant Gliomas

1998 • 18 citations

Prognostic Significance of Tumor Vascularity

1999 • 17 citations

A diaminoantraquinone inhibitor of angiogenesis.

1994 • 16 citations

Characterization of the Effects of Two Polysulfonated Distamycin A Derivatives, PNU145156E and PNU153429, on HIV Type 1 Tat Protein

1998 • 15 citations

Potentiation of Cytotoxic Cancer Therapies by Antiangiogenic Agents

1999 • 15 citations

Overview Oncologic, Endocrine & Metabolic: Recent advances in angiogenesis inhibitors

1994 • 12 citations

Inhibition of Growth Factor Mitogenicity and Growth of Tumor Cell Xenografts by a Sulfonated Distamycin A Derivative

1997 • 11 citations

Metabolism of tumor regression from angiogenesis inhibition: ³¹P magnetic resonance spectroscopy

1989 • 11 citations

Æ-941, an inhibitor of angiogenesis: rationale for development in combination with induction chemotherapy/radiotherapy in patients with non-small-cell lung cancer (nsclc)

1999 • 11 citations

Endpoints for Determination of Efficacy of Antiangiogenic Agents in Clinical Trials

1999 • 10 citations

Captopril Inhibits Peptidylglycine- α-Hydroxylating Monooxygenase: Implications for Therapeutic Effects

1999 • 7 citations

The Development of Therapeutic Angiosuppression: Problems and Progress

1992 • 6 citations

Angiosuppression

1992 • 2 citations

Retinoids and Interferons as Antiangiogenic Cancer Drugs

1999 • 2 citations