Immunolocalization of basic fibroblast growth factor to the micro vasculature of human brain tumors

Tumor Angiogenesis: Therapeutic Implications

1971 • 9,898 citations

Tumor Angiogenesis and Metastasis — Correlation in Invasive Breast Carcinoma

1991 • 5,657 citations

Angiogenic Factors

1987 • 3,702 citations

Transplacental Carcinogenesis by Stilbestrol

1971 • 2,595 citations

Autocrine growth factors and cancer

1985 • 1,462 citations

Structural Characterization and Biological Functions of Fibroblast Growth Factor

1987 • 1,299 citations

Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesis

1977 • 1,286 citations

Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis.

1989 • 1,282 citations

A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas

1990 • 1,140 citations

Recent developments in the cell biology of basic fibroblast growth factor.

1989 • 1,049 citations

Endothelial cell-derived basic fibroblast growth factor: synthesis and deposition into subendothelial extracellular matrix.

1987 • 1,045 citations

Heparin Affinity: Purification of a Tumor-Derived Capillary Endothelial Cell Growth Factor

1984 • 937 citations

Grading of astrocytomas: A simple and reproducible method

1988 • 902 citations

A heparin-binding angiogenic protein--basic fibroblast growth factor--is stored within basement membrane.

1988 • 892 citations

Peptide growth factors are multifunctional

1988 • 835 citations

Capillary endothelial cells express basic fibroblast growth factor, a mitogen that promotes their own growth

1987 • 764 citations

Basic fibroblast growth factor binds to subendothelial extracellular matrix and is released by heparitinase and heparin-like molecules

1989 • 597 citations

Release of basic fibroblast growth factor-heparan sulfate complexes from endothelial cells by plasminogen activator-mediated proteolytic activity.

1990 • 545 citations

Distribution of basic fibroblast growth factor in the 18-day rat fetus: localization in the basement membranes of diverse tissues.

1990 • 533 citations

Tumor Angiogenesis: A Quantitative Method for Histologic Grading<xref ref-type="fn" rid="FN2">2</xref>

1972 • 418 citations

Increased basic fibroblast growth factor (bFGF) immunoreactivity at the site of focal brain wounds

1988 • 382 citations

Basic fibroblast growth factor fused to a signal peptide transforms cells

1988 • 379 citations

Fibroblast Growth Factors

1991 • 360 citations

Alternative initiation of translation determines cytoplasmic or nuclear localization of basic fibroblast growth factor.

1991 • 346 citations

Growth factors in the regulation of pericellular proteolysis: a review.

1989 • 342 citations

The extracellular matrix of the central and peripheral nervous systems: structure and function

1988 • 313 citations

Endothelial cell hyperplasia in human glioblastoma: coexpression of mRNA for platelet-derived growth factor (PDGF) B chain and PDGF receptor suggests autocrine growth stimulation.

1988 • 288 citations

Gene expression of fibroblast growth factors in human gliomas and meningiomas: demonstration of cellular source of basic fibroblast growth factor mRNA and peptide in tumor tissues.

1990 • 279 citations

Proliferation of human malignant melanomas is inhibited by antisense oligodeoxynucleotides targeted against basic fibroblast growth factor.

1989 • 270 citations

Increased capillary endothelial cell protease activity in response to angiogenic stimuli in vitro.

1983 • 261 citations

Purification of a glycoprotein vascular endothelial cell mitogen from a rat glioma-derived cell line.

1990 • 230 citations

Inhibition of angiogenesis and tumor growth in the brain. Suppression of endothelial cell turnover by penicillamine and the depletion of copper, an angiogenic cofactor.

1990 • 230 citations

Brain Tumors

1991 • 224 citations

Cancer invasion and metastasis : biologic and therapeutic aspects

1984 • 221 citations

Intratumoral histologic heterogeneity of gliomas. A quantitative study

1989 • 215 citations

Correlation of cell migration, cell invasion, receptor number, proteinase production, and basic fibroblast growth factor levels in endothelial cells.

1990 • 205 citations

Fibroblast growth factors

1989 • 202 citations

Angiogenesis as a marker of preneoplastic lesions of the human breast

1978 • 199 citations

Effects of irradiation on the release of growth factors from cultured bovine, porcine, and human endothelial cells.

1989 • 197 citations

The endothelial hyperplasia of the cerebral blood vessels with brain tumors, and its sarcomatous transformation

1958 • 177 citations

Isolation, characterization, and localization of heparin-binding growth factors in the heart.

1990 • 175 citations

Immunohistochemical localization of basic fibroblast growth factor in astrocytomas.

1990 • 167 citations

Prognostic implications of the proliferative potential of low-grade astrocytomas

1988 • 155 citations

Growth factors adherent to cell substrate are mitogenically active in situ

1982 • 141 citations

Acidic and basic fibroblast growth factors are present in glioblastoma multiforme.

1991 • 129 citations

Autocrine transformation by chimeric signal peptide-basic fibroblast growth factor: reversal by suramin.

1990 • 123 citations

The Role of Vascular Proliferation in the Growth of Brain Tumors

1976 • 118 citations

Immunocytochemical study of transforming growth factor expression in benign and malignant gliomas.

1989 • 108 citations

Differential macromolecular leakage from the vasculature of tumors

1986 • 100 citations

Biology of Gliomas

1981 • 96 citations

Localization of basic fibroblast growth factor, a mitogen and angiogenic factor, in human brain tumors

1990 • 95 citations

Basic fibroblast growth factor-like activity and receptors are expressed in a human glioma cell line.

1990 • 92 citations

Plasminogen activator and inhibitor activity in human glioma cells and modulation by sodium butyrate.

1988 • 91 citations

Localization of basic fibroblast growth factor to the developing capillaries of the bovine retina

1989 • 88 citations

Serum and fibroblast growth factor stimulate quiescent astrocytes to re-enter the cell cycle

1988 • 86 citations

Growth factor biology and oncogene activation in human gliomas and their implications for specific therapeutic concepts

1989 • 73 citations

Monoclonal antibodies directed against basic fibroblast growth factor which inhibit its biological activity in vitro and in vivo

1989 • 72 citations

Basic fibroblast growth factor: A potential autocrine regulator of human glioma cell growth

1990 • 68 citations

Immunocytochemical localization of basic fibroblast growth factor in bovine adrenal gland, ovary, and pituitary.

1989 • 66 citations

Angiogenesis and blood-brain barrier breakdown modulate CT contrast enhancement: an experimental study in a rabbit brain-tumor model

1989 • 60 citations

Growth Factor Biology and Oncogene Activation in Human Gliomas and Their Implications for Specific Therapeutic Concepts

1989 • 59 citations

Correlation of histopathological features and proliferative potential of gliomas

1989 • 57 citations

Mechanisms of Tumor-Associated Edema: A Review

1990 • 54 citations

Multiple forms of an angiogenesis factor: basic fibroblast growth factor

1988 • 52 citations

Neovascularization and tumor growth in the rabbit brain. A model for experimental studies of angiogenesis and the blood-brain barrier.

1988 • 49 citations

The Cycling Pool of Cells within Human Brain Tumors:In SituCytokinetics Using the Monoclonal Antibody Ki-67

1991 • 48 citations

Intercapillary distance in the proliferating area of human glioma.

1988 • 47 citations

Epidermal growth factor receptor in meningiomas is expressed predominantly on endothelial cells

1988 • 47 citations

Involvement of protein kinase C in the mitogenic and chemotaxis effects of basic fibroblast growth factor on bovine cerebral cortex capillary endothelial cells

1990 • 43 citations

Renin in Glioblastoma Multiforme and Its Role in Neovascularization

1988 • 43 citations

Affinity of fibroblast growth factors for β-cyclodextrin tetradecasulfate

1990 • 39 citations

Heparin-copper biaffinity chromatography of fibroblast growth factors.

1988 • 38 citations

Expression, Processing, and Properties of int‐2

1991 • 36 citations

Characterization of tumors produced by signal peptide‐basic fibroblast growth factor‐transformed cells

1989 • 30 citations

Rapid in situ cellular kinetics of intracerebral tumor angiogenesis using a monoclonal antibody to bromodeoxyuridine

1989 • 26 citations

Proliferative potential of vascular components in human glioblastoma multiforme

1987 • 26 citations

Statin immunolocalization in human brain tumors. Detection of noncycling cells using a novel marker of cell quiescence

1991 • 24 citations

Rapid In Situ Cellular Kinetics of Intracerebral Tumor Angiogenesis Using a Monoclonal Antibody to Bromodeoxyuridine

1989 • 21 citations

Biosynthesis and storage of basic fibroblast growth factor (bFGF) by endothelial cells: implication for the mechanism of action of angiogenesis.

1988 • 20 citations

Contrast-enhancing computed tomography ring in glioblastoma multiforme after intraoperative endocurietherapy

1988 • 14 citations

Tumor growth regulation by modulation of basic fibroblast growth factor

1992 • 11 citations

Recent perspectives in brain tumor biology and treatment.

1989 • 8 citations

The Development of Therapeutic Angiosuppression: Problems and Progress

1992 • 6 citations