Captopril inhibits angiogenesis and slows the growth of experimental tumors in rats.

ISIS-4: A randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58 050 patients with suspected acute myocardial infarction

1995 • 1,786 citations

Overview of randomized trials of angiotensin-converting enzyme inhibitors on mortality and morbidity in patients with heart failure. Collaborative Group on ACE Inhibitor Trials

1995 • 1,526 citations

Overview of Randomized Trials of Angiotensin-Converting Enzyme Inhibitors on Mortality and Morbidity in Patients With Heart Failure

1995 • 1,301 citations

New principle for the analysis of chemical carcinogenesis

1976 • 788 citations

Peptides derived from two separate domains of the matrix protein thrombospondin-1 have anti-angiogenic activity

1993 • 574 citations

Secretion of metalloproteinases by stimulated capillary endothelial cells. II. Expression of collagenase and stromelysin activities is regulated by endogenous inhibitors.

1986 • 531 citations

How Tumors Become Angiogenic

1996 • 514 citations

Endothelin-converting Enzyme-2 Is a Membrane-bound, Phosphoramidon-sensitive Metalloprotease with Acidic pH Optimum

1995 • 496 citations

Identification of an Inhibitor of Neovascularization from Cartilage

1990 • 481 citations

Antiatherogenic effect of captopril in the Watanabe heritable hyperlipidemic rabbit.

1990 • 419 citations

Neovascularization produced by angiotensin II.

1985 • 392 citations

Induction of neovascularization in vivo and endothelial proliferation in vitro by tumor-associated macrophages.

1984 • 366 citations

Tissue inhibitor of metalloproteinases‐2 inhibits bFGF‐induced human microvascular endothelial cell proliferation

1993 • 362 citations

ISIS-4: a randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58,050 patients with suspected acute myocardial infarction. ISIS-4 (Fourth International Study of Infarct Survival) Collaborative Group.

1995 • 250 citations

Population kinetics of carcinoma cells, capillary endothelial cells, and fibroblasts in a transplanted mouse mammary tumor.

1970 • 243 citations

Partial purification and characterization of a neutral protease which cleaves type IV collagen

1981 • 241 citations

Interstitial Collagenase Is Required for Angiogenesis in Vitro

1994 • 231 citations

Correlation of cell migration, cell invasion, receptor number, proteinase production, and basic fibroblast growth factor levels in endothelial cells.

1990 • 205 citations

Angiotensin II stimulates angiogenesis in the chorio-allantoic membrane of the chick embryo

1991 • 184 citations

Influence of the angiotensin system on endothelial and smooth muscle cell migration.

1990 • 184 citations

Captopril reduces aortic and microvascular growth in hypertensive and normotensive rats.

1990 • 162 citations

CAPTOPRIL: A NEW TREATMENT FOR RHEUMATOID ARTHRITIS?

1984 • 161 citations

Purification and characterization of endothelin-converting enzyme from rat lung.

1993 • 154 citations

Induction of angiogenesis in chick yolk-sac membrane by polyamines and its inhibition by tissue inhibitors of metalloproteinases (TIMP and TIMP-2)

1990 • 154 citations

Pharmacokinetics of Captopril in Healthy Subjects and in Patients with Cardiovascular Diseases

1988 • 146 citations

Oral administration of L-arginine and captopril in rats prevents chronic renal failure by nitric oxide production

1995 • 133 citations

Evidence for a novel angiotensin II receptor involved in angiogenesis in chick embryo chorioallantoic membrane

1993 • 128 citations

Inhibition of human endothelial cell proliferation in vitro and neovascularization in vivo by D-penicillamine.

1989 • 123 citations

Captopril: Pharmacology, Metabolism, and Disposition

1984 • 104 citations

Radiation-induced pulmonary endothelial dysfunction in rats: Modification by an inhibitor of angiotensin converting enzyme

1988 • 95 citations

Effects of converting-enzyme inhibitors on the renin-angiotensin-aldosterone, bradykinin, and arachidonic acid-prostaglandin systems: correlation of chemical structure and biologic activity.

1987 • 95 citations

Isolation and characterization of an inhibitor of neovascularization from scapular chondrocytes.

1992 • 93 citations

Captopril inhibits the 72 kDa and 92 kDa matrix metalloproteinases

1993 • 91 citations

Thrombospondin stimulates motility of human neutrophils.

1990 • 87 citations

Inhibition of leukotriene A4 hydrolase/aminopeptidase by captopril.

1991 • 86 citations

Salt intake and angiotensin II alter microvessel density in the cremaster muscle of normal rats

1992 • 78 citations

Angiotensin‐converting enzyme inhibitors during pregnancy: a survey of 22 patients given captopril and nine given enalapril

1988 • 77 citations

A permanent human cell line (EA.hy926) preserves the characteristics of endothelin converting enzyme from primary human umbilical vein endothelial cells

1995 • 74 citations

Assay and purification of naturally occurring inhibitor of angiogenesis

1991 • 73 citations

Angiotensin-Converting Enzyme Inhibitors in Hypertension

1994 • 72 citations

The effect of Captopril on benign and malignant reactions in irradiated rat skin

1990 • 58 citations

Captopril increases skin microvascular blood flow secondary to bradykinin, nitric oxide, and prostaglandins

1995 • 53 citations

Autocrine angiotensin system regulation of bovine aortic endothelial cell migration and plasminogen activator involves modulation of proto-oncogene pp60c-src expression.

1992 • 46 citations

The Expanding Role of Angiotensin Converting Enzyme Inhibitors in the Management of Hypertension

1995 • 32 citations

Angiotensin-converting enzyme inhibitor therapy and diabetic retinopathy.

1992 • 32 citations

[11] Assay of capillary endothelial cell migration

1987 • 27 citations

Angiotensin-converting enzyme inhibitors in heart failure: new strategies justified by recent clinical trials

1994 • 20 citations

Evaluation of the rat embryo culture system as a predictive test for human teratogens

1994 • 18 citations

Inhibition of dopamine β-hydroxylase by captopril

1989 • 14 citations

Angiotensin-converting enzyme inhibitor therapy and diabetic retinopathy.

1992 • 14 citations

Role of sulfhydryl groups an the stimulatory effect of captopril on vascular prostacyclin synthesis

1991 • 10 citations

Increase of Migration of Cultured Endothelial Cells by Angiotensin-Converting Enzyme Inhibitor Derived from Tuna Muscle.

1992 • 7 citations

Captopril and diabetic nephropathy

1995 • 2 citations

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