Role of Vascular Endothelial Growth Factor in Regulation of Angiogenesis

Angiogenesis in cancer, vascular, rheumatoid and other disease

1995 • 7,717 citations

Mechanisms of angiogenesis

1997 • 5,696 citations

Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen

1989 • 4,988 citations

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1992 • 4,631 citations

Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth

1997 • 4,504 citations

The Biology of Vascular Endothelial Growth Factor

1997 • 4,359 citations

Tumors: Wounds That Do Not Heal

1986 • 4,202 citations

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

1996 • 4,143 citations

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1995 • 3,977 citations

Activation of Vascular Endothelial Growth Factor Gene Transcription by Hypoxia-Inducible Factor 1

1996 • 3,851 citations

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

1996 • 3,664 citations

Vascular Endothelial Growth Factor in Ocular Fluid of Patients with Diabetic Retinopathy and Other Retinal Disorders

1994 • 3,652 citations

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

1993 • 3,605 citations

Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis

1997 • 3,470 citations

Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma

1994 • 3,367 citations

Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.

1995 • 3,139 citations

Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis

1996 • 2,844 citations

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

1995 • 2,650 citations

Angiogenesis.

1992 • 2,581 citations

Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo

1992 • 2,293 citations

Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells

1989 • 2,267 citations

The fms -Like Tyrosine Kinase, a Receptor for Vascular Endothelial Growth Factor

1992 • 2,042 citations

Purification and Characterization of Hypoxia-inducible Factor 1

1995 • 2,010 citations

The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing

1991 • 1,991 citations

Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning

1996 • 1,969 citations

High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

1993 • 1,961 citations

Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells

1996 • 1,908 citations

Inducible Gene Targeting in Mice

1995 • 1,897 citations

A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases.

1996 • 1,670 citations

Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor.

1994 • 1,661 citations

Molecular and Biological Properties of the Vascular Endothelial Growth Factor Family of Proteins

1992 • 1,612 citations

Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity

1995 • 1,608 citations

Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders.

1997 • 1,590 citations

Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor

1992 • 1,528 citations

The Vascular Endothelial Growth Factor Family: Identification of a Fourth Molecular Species and Characterization of Alternative Splicing of RNA

1991 • 1,375 citations

Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1

1996 • 1,355 citations

Definition of Two Angiogenic Pathways by Distinct α _v Integrins

1995 • 1,333 citations

Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins.

1995 • 1,280 citations

Hyperplasia of Lymphatic Vessels in VEGF-C Transgenic Mice

1997 • 1,280 citations

Increased Vascular Endothelial Growth Factor Levels in the Vitreous of Eyes With Proliferative Diabetic Retinopathy

1994 • 1,269 citations

Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant

1994 • 1,249 citations

The Biology of Vascular Endothelial Growth Factor

1997 • 1,203 citations

Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms.

1992 • 1,145 citations

The vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF.

1993 • 1,114 citations

Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR.

1994 • 1,104 citations

Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation

1992 • 1,103 citations

Transcriptional Regulation of the Rat Vascular Endothelial Growth Factor Gene by Hypoxia

1995 • 1,087 citations

A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin.

1990 • 1,062 citations

Therapeutic angiogenesis. A single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model.

1994 • 1,058 citations

Interleukin 6 Induces the Expression of Vascular Endothelial Growth Factor

1996 • 1,031 citations

Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor

1995 • 1,026 citations

Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization.

1995 • 1,021 citations

Hypoxia Regulates Vascular Endothelial Growth Factor Gene Expression in Endothelial Cells

1995 • 1,001 citations

Development of retinal vasculature is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neuroglia

1995 • 990 citations

Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family.

1990 • 982 citations

Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb

1996 • 980 citations

Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein.

1996 • 886 citations

Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogenesis in vitro

1992 • 865 citations

Vascular permeability factor: a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration.

1990 • 857 citations

Differential Transcriptional Regulation of the Two Vascular Endothelial Growth Factor Receptor Genes

1997 • 792 citations

Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis.

1995 • 766 citations

Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium.

1993 • 764 citations

Regulation of Vascular Endothelial Growth Factor Expression in Cultured Keratinocytes.

1995 • 764 citations

Identification of a Natural Soluble Form of the Vascular Endothelial Growth Factor Receptor, FLT-1, and Its Heterodimerization with KDR

1996 • 725 citations

Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody

1996 • 718 citations

flk-1, an flt-related receptor tyrosine kinase is an early marker for endothelial cell precursors

1993 • 707 citations

Vascular endothelial growth factor is induced in response to transforming growth factor-beta in fibroblastic and epithelial cells.

1994 • 702 citations

Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis.

1995 • 699 citations

Overexpression of vascular permeability factor/vascular endothelial growth factor and its receptors in psoriasis.

1994 • 680 citations

Prognostic value of vascular endothelial growth factor expression in gastric carcinoma

1996 • 648 citations

Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in adenocarcinomas of the gastrointestinal tract.

1993 • 645 citations

Vascular endothelial growth factor is essential for corpus luteum angiogenesis

1998 • 641 citations

Post-transcriptional Regulation of Vascular Endothelial Growth Factor by Hypoxia

1996 • 639 citations

Inhibition of Vascular Endothelial Growth Factor Prevents Retinal Ischemia—Associated Iris Neovascularization in a Nonhuman Primate

1996 • 638 citations

Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells

1991 • 626 citations

Ovarian steroid regulation of vascular endothelial growth factor in the human endometrium: implications for angiogenesis during the menstrual cycle and in the pathogenesis of endometriosis.

1996 • 623 citations

Subfoveal fibrovascular membranes in age-related macular degeneration express vascular endothelial growth factor

1996 • 622 citations

Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer

1995 • 622 citations

The Carboxyl-terminal Domain(111–165) of Vascular Endothelial Growth Factor Is Critical for Its Mitogenic Potency

1996 • 615 citations

Hypoxia-induced Transcriptional Activation and Increased mRNA Stability of Vascular Endothelial Growth Factor in C6 Glioma Cells

1995 • 608 citations

Transdifferentiated Retinal Pigment Epithelial Cells are Immunoreactive for Vascular Endothelial Growth Factor in Surgically Excised AgeRelated Macular Degeneration-Related Choroidal Neovascular Membranes.

1998 • 590 citations

Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Flt in lungs exposed to acute or to chronic hypoxia. Modulation of gene expression by nitric oxide.

1995 • 590 citations

Vascular endothelial growth factor/vascular permeability factor is temporally and spatially correlated with ocular angiogenesis on a primate model

1994 • 584 citations

Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin.

1994 • 584 citations

Vascular endothelial growth factor. A cytokine modulating endothelial function in rheumatoid arthritis.

1994 • 570 citations

Induction of vascular endothelial growth factor expression in synovial fibroblasts by prostaglandin E and interleukin‐1: a potential mechanism for inflammatory angiogenesis

1995 • 565 citations

Increased expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in kidney and bladder carcinomas.

1993 • 564 citations

Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene.

1996 • 541 citations

Epidermal growth factor stimulates vascular endothelial growth factor production by human malignant glioma cells: a model of glioblastoma multiforme pathophysiology.

1993 • 534 citations

Patterns of expression of vascular endothelial growth factor (VEGF) and VEGF receptors in mice suggest a role in hormonally regulated angiogenesis.

1993 • 534 citations

Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells

1992 • 530 citations

Identification of a new endothelial cell growth factor receptor tyrosine kinase

1991 • 529 citations

VEGF145, a Secreted Vascular Endothelial Growth Factor Isoform That Binds to Extracellular Matrix

1997 • 529 citations

Vascular permeability factor/endothelial growth factor (VPF/VEGF): accumulation and expression in human synovial fluids and rheumatoid synovial tissue.

1994 • 524 citations

A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit.

1991 • 516 citations

Prognostic Significance of Vascular Endothelial Growth Factor Protein in Node-Negative Breast Carcinoma

1997 • 503 citations

Up-regulation of vascular endothelial growth factor and its cognate receptors in a rat glioma model of tumor angiogenesis.

1993 • 502 citations

Identification of Vascular Endothelial Growth Factor Determinants for Binding KDR and FLT-1 Receptors

1996 • 497 citations

A unique signal transduction from FLT tyrosine kinase, a receptor for vascular endothelial growth factor VEGF.

1995 • 480 citations

Vascular Endothelial Cell Growth Factor Promotes Tyrosine Phosphorylation of Mediators of Signal Transduction That Contain SH2 Domains

1995 • 480 citations

Assignment of the Vascular Endothelial Growth Factor Gene to Human Chromosome 6p21.3

1996 • 473 citations

Expression of the vascular permeability factor/vascular endothelial growth factor gene in central nervous system neoplasms.

1993 • 467 citations

Vascular endothelial growth factor receptor expression during embryogenesis and tissue repair suggests a role in endothelial differentiation and blood vessel growth.

1993 • 460 citations

The mode of development of the vascular system of the retina, with some observations on its significance for certain retinal diseases

1948 • 456 citations

Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression.

1994 • 453 citations

Fibrin containing gels induce angiogenesis. Implications for tumor stroma generation and wound healing.

1987 • 450 citations

During angiogenesis, vascular endothelial growth factor regulate natural killer cell adhesion to tumor endothelium

1996 • 449 citations

Vascular endothelial growth factor induces EDRF-dependent relaxation in coronary arteries

1993 • 448 citations

Vascular endothelial growth factor: Crystal structure and functional mapping of the kinase domain receptor binding site

1997 • 443 citations

Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues.

1992 • 443 citations

Neovasculature induced by vascular endothelial growth factor is fenestrated.

1997 • 441 citations

Vascular endothelial growth factor/vascular permeability factor expression in the rat uterus: rapid stimulation by estrogen correlates with estrogen-induced increases in uterine capillary permeability and growth.

1993 • 437 citations

Hypoxic stimulation of vascular endothelial growth factor expression in vitro and in vivo.

1994 • 433 citations

Upregulation of vascular endothelial growth factor expression induced by myocardial ischaemia: implications for coronary angiogenesis

1994 • 430 citations

Nitric oxide mediates mitogenic effect of VEGF on coronary venular endothelium

1996 • 423 citations

Dominant-negative inhibition of Flk-1 suppresses the growth of many tumor types in vivo.

1996 • 423 citations

A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases.

1996 • 416 citations

Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4.

1996 • 406 citations

The angiogenesis induced by HIV–1 Tat protein is mediated by the Flk–1/KDR receptor on vascular endothelial cells

1996 • 382 citations

Expression of vascular permeability factor/vascular endothelial growth factor in normal rat tissues

1993 • 369 citations

Amino acid and cDNA sequences of a vascular endothelial cell mitogen that is homologous to platelet-derived growth factor.

1990 • 368 citations

Detection of Vascular Endothelial Growth Factor Messenger RNA and Vascular Endothelial Growth Factor-like Activity in Proliferative Diabetic Retinopathy

1994 • 367 citations

Expression of vascular endothelial growth factor, its receptor, and other angiogenic factors in human breast cancer.

1996 • 366 citations

Hypoxic Induction of Endothelial Cell Growth Factors in Retinal Cells: Identification and Characterization of Vascular Endothelial Growth Factor (VEGF) as the Mitogen

1995 • 357 citations

Vascular endothelial growth factor. Regulation by cell differentiation and activated second messenger pathways.

1992 • 355 citations

Hypoxia-induced paracrine regulation of vascular endothelial growth factor receptor expression.

1996 • 351 citations

Induction of Vascular Endothelial Growth Factor Gene Expression by Interleukin-1 β in Rat Aortic Smooth Muscle Cells

1995 • 347 citations

Vascular endothelial growth factor (VEGF) concentrations are elevated in peritoneal fluid of women with endometriosis

1996 • 342 citations

VEGF, flk-1, and flt-1 expression in a rat myocardial infarction model of angiogenesis

1996 • 342 citations

Expression of vascular permeability factor/vascular endothelial growth factor by human granulosa and theca lutein cells. Role in corpus luteum development.

1995 • 338 citations

Both v-Ha-Ras and v-Raf Stimulate Expression of the Vascular Endothelial Growth Factor in NIH 3T3 Cells

1995 • 336 citations

Complete inhibition of angiogenesis and growth of microtumors by anti-vascular endothelial growth factor neutralizing antibody: novel concepts of angiostatic therapy from intravital videomicroscopy.

1996 • 336 citations

The Mouse Gene for Vascular Endothelial Growth Factor

1996 • 335 citations

Magnetic resonance mapping demonstrates benefits of VEGF–induced myocardial angiogenesis

1995 • 330 citations

Up-regulation of vascular endothelial growth factor and its receptors in von Hippel-Lindau disease-associated and sporadic hemangioblastomas.

1995 • 329 citations

Reversion of deregulated expression of vascular endothelial growth factor in human renal carcinoma cells by von Hippel-Lindau tumor suppressor protein.

1996 • 315 citations

Characterization of the receptors for vascular endothelial growth factor.

1990 • 310 citations

The Vascular Endothelial Growth Factor Proteins: Identification of Biologically Relevant Regions by Neutralizing Monoclonal Antibodies

1992 • 309 citations

Vascular endothelial growth factor, platelet-derived growth factor, and insulin-like growth factor-1 promote rat aortic angiogenesis in vitro.

1994 • 297 citations

FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines.

1992 • 285 citations

Vascular Permeability Factor (Vascular Endothelial Growth Factor) Expression and Angiogenesis in Cervical Neoplasia

1995 • 285 citations

Vascular Endothelial Growth Factor is Expressed in Rat Corpus Luteum

1990 • 284 citations

Induction of Vascular Endothelial Growth Factor by Insulin-like Growth Factor 1 in Colorectal Carcinoma

1996 • 272 citations

Vascular Endothelial Growth Factor Increases Urokinase Receptor Expression in Vascular Endothelial Cells

1995 • 269 citations

Developmental expression of binding sites and messenger ribonucleic acid for vascular endothelial growth factor suggests a role for this protein in vasculogenesis and angiogenesis.

1993 • 262 citations

Vascular endothelial growth factor messenger ribonucleic acid expression in the primate ovary.

1992 • 259 citations

Vascular permeability factor gene expression in normal and neoplastic human ovaries.

1994 • 259 citations

Inhibition of tumor growth and metastasis by an immunoneutralizing monoclonal antibody to human vascular endothelial growth factor/vascular permeability factor121.

1995 • 257 citations

Hypotensive Activity of Fibroblast Growth Factor

1991 • 246 citations

Effects of Vascular Endothelial Growth Factor on Hemodynamics and Cardiac Performance

1996 • 245 citations

Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth factor expression.

1996 • 240 citations

Prognostic value of vascular endothelial growth factor and its receptor Flt-1 in squamous cell lung cancer

1997 • 223 citations

Expression of vascular permeability factor/vascular endothelial growth factor in human hepatocellular carcinoma.

1996 • 221 citations

The 16K Fragment of Prolactin Specifically Inhibits Basal or Fibroblast Growth Factor Stimulated Growth of Capillary Endothelial Cells

1991 • 217 citations

Rapid induction of vascular endothelial growth factor expression by transient ischemia in rat heart

1994 • 215 citations

Parvalbumin relaxes frog skeletal muscle when sarcoplasmic reticulum Ca(2+)-ATPase is inhibited

1996 • 215 citations

The second immunoglobulin-like domain of the VEGF tyrosine kinase receptor Flt-1 determines ligand binding and may initiate a signal transduction cascade.

1996 • 202 citations

Quantitative analysis of vascular endothelial growth factor in primary breast cancer

1996 • 199 citations

Differential Mitotic Phosphorylation of Proteins of the Nuclear Pore Complex

1995 • 198 citations

Vascular endothelial growth factor/vascular permeability factor is detectable in the sera of tumor-bearing mice and cancer patients

1994 • 198 citations

In the human fetus, vascular endothelial growth factor is expressed in epithelial cells and myocytes, but not vascular endothelium: implications for mode of action.

1994 • 196 citations

Stimulation by thyroid-stimulating hormone and Grave's immunoglobulin G of vascular endothelial growth factor mRNA expression in human thyroid follicles in vitro and flt mRNA expression in the rat thyroid in vivo.

1995 • 182 citations

Slowed Release of Thrombin-cleaved Factor VIII from von Willebrand Factor by a Monoclonal and a Human Antibody Is a Novel Mechanism for Factor VIII Inhibition

1996 • 175 citations

Cloning and Functional Analysis of the Promoter for KDR/flk-1, a Receptor for Vascular Endothelial Growth Factor

1995 • 173 citations

Downregulation of vascular endothelial growth factor receptors by tumor necrosis factor-alpha in cultured human vascular endothelial cells.

1996 • 170 citations

Expression of vascular endothelial growth factor does not promote transformation but confers a growth advantage in vivo to Chinese hamster ovary cells.

1993 • 167 citations

Characterization of vascular permeability factor/vascular endothelial growth factor receptors on mononuclear phagocytes

1993 • 167 citations

Transforming Growth Factor β1 Down-regulates Vascular Endothelial Growth Factor Receptor 2/flk-1 Expression in Vascular Endothelial Cells

1996 • 164 citations

HIV-tat protein is a heparin-binding angiogenic growth factor.

1996 • 152 citations

Increased Expression of Vascular Permeability Factor (Vascular Endothelial Growth Factor) in Bullous Pemphigoid, Dermatitis Herpetiformis, and Erythema Multiforme

1995 • 148 citations

Regulation of hexose transport in aortic endothelial cells by vascular permeability factor and tumor necrosis factor-alpha, but not by insulin.

1990 • 137 citations

A 24-base-pair sequence 3' to the human erythropoietin gene contains a hypoxia-responsive transcriptional enhancer.

1993 • 131 citations

Vascular endothelial growth factor promotes tumor dissemination by a mechanism distinct from its effect on primary tumor growth.

1996 • 130 citations

A Novel Promoter for Vascular Endothelial Growth Factor Receptor (flt-1) That Confers Endothelial-specific Gene Expression

1995 • 130 citations

Hypoxia regulates vascular endothelial growth factor receptor KDR/Flk gene expression through adenosine A2 receptors in retinal capillary endothelial cells.

1996 • 129 citations

Studies on retinal neovascularization. Friedenwald Lecture.

1980 • 127 citations

Characterization of vascular permeability factor/vascular endothelial growth factor receptors on mononuclear phagocytes

1993 • 127 citations

Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in endometrial carcinoma

1996 • 126 citations

Interaction of the Flt-1 Tyrosine Kinase Receptor with the p85 Subunit of Phosphatidylinositol 3-Kinase

1995 • 123 citations

Characterization of the receptor to vasculotropin on bovine adrenal cortex-derived capillary endothelial cells.

1990 • 120 citations

Ultrastructural localization of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) to the abluminal plasma membrane and vesiculovacuolar organelles of tumor microvascular endothelium.

1995 • 118 citations

Vascular endothelial growth factor/vascular permeability factor expression in the rat uterus: rapid stimulation by estrogen correlates with estrogen-induced increases in uterine capillary permeability and growth

1993 • 118 citations

Myeloid progenitor cell regulatory effects of vascular endothelial cell growth factor.

1995 • 116 citations

Neovascularization in human germ cell tumors correlates with a marked increase in the expression of the vascular endothelial growth factor but not the placenta-derived growth factor.

1996 • 112 citations

Coding sequence of the overexpressed transcript of the putative oncogene PRAD1/cyclin D1 in two primary human tumors.

1993 • 107 citations

The 70-kDa Heat Shock Proteins Associate with Glandular Intermediate Filaments in an ATP-dependent Manner

1995 • 104 citations

Immunoadhesins: principles and applications

1996 • 100 citations

Targeting the mouse genome: a compendium of knockouts (part II)

1995 • 99 citations

The potential aggressiveness of synovial tissue in rheumatoid arthritis

1983 • 95 citations

Molecular cloning of murine FLT and FLT4.

1993 • 90 citations

Vascular endothelial growth factor messenger ribonucleic acid expression in the primate ovary

1992 • 90 citations

Expression of vascular endothelial growth factor and its receptor mRNA in angiosarcoma.

1995 • 83 citations

Chromosomal localization of FLT4, a novel receptor-type tyrosine kinase gene

1992 • 82 citations

In the human fetus, vascular endothelial growth factor is expressed in epithelial cells and myocytes, but not vascular endothelium: implications for mode of action

1994 • 80 citations

Correction of hypertension by normalization of endothelial levels of fibroblast growth factor and nitric oxide synthase in spontaneously hypertensive rats.

1996 • 77 citations

Developmental expression of binding sites and messenger ribonucleic acid for vascular endothelial growth factor suggests a role for this protein in vasculogenesis and angiogenesis

1993 • 74 citations

Thrombospondin as a regulator of angiogenesis

1997 • 53 citations

Angiogenic growth factors and their receptors in non-small cell lung carcinomas and their relationships to drug response in vitro.

1997 • 52 citations

Genetic Analysis of Blood Vessel Formation

1997 • 42 citations

Targeting the mouse genome: a compendium of knockouts (part III)

1995 • 41 citations

INTENSE FOCAL EXPRESSION OF VASCULAR ENDOTHELIAL GROWTH-FACTOR MESSENGER-RNA IN HUMAN INTRACRANIAL NEOPLASMS - ASSOCIATION WITH REGIONS OF NECROSIS

1993 • 40 citations

Diabetic Retinopathy: Practical Management

1993 • 40 citations

Structural rearrangements in active and inactive forms of hydrogenase from Thiocapsa roseopersicina.

1991 • 28 citations

SH3 Domains Specifically Regulate Kinase Activity of Expressed Src Family Proteins

1995 • 25 citations

Inhibition of vascular endothelial cell growth factor suppresses the in vivo growth of human prostate tumors

1997 • 19 citations

Deleted Work

1955 • 0 citations