Inhibition of Tumor Angiogenesis^a

Tumor Angiogenesis: Therapeutic Implications

1971 • 9,898 citations

Transplacental Carcinogenesis by Stilbestrol

1971 • 2,595 citations

Goodman and Gilman's The Pharmacological Basis of Therapeutics

1991 • 1,330 citations

Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth

1990 • 1,308 citations

Anti-Angiogenesis

1972 • 1,167 citations

Polymers for the sustained release of proteins and other macromolecules

1976 • 1,127 citations

TUMOR DORMANCY IN VIVO BY PREVENTION OF NEOVASCULARIZATION

1972 • 898 citations

SELF-REGULATION OF GROWTH IN THREE DIMENSIONS

1973 • 811 citations

Tumor Growth and Neovascularization: An Experimental Model Using the Rabbit Cornea 2

1974 • 762 citations

Inhibition of Angiogenesis by Recombinant Human Platelet Factor-4 and Related Peptides

1990 • 710 citations

Angiogenesis Inhibition and Tumor Regression Caused by Heparin or a Heparin Fragment in the Presence of Cortisone

1983 • 622 citations

Protamine is an inhibitor of angiogenesis

1982 • 582 citations

Tetracyclines Inhibit Connective Tissue Breakdown: New Therapeutic Implications for an Old Family of Drugs

1991 • 522 citations

A New Class of Steroids Inhibits Angiogenesis in the Presence of Heparin or a Heparin Fragment

1985 • 492 citations

Inhibition of angiogenesis by interferons: effects on tumor- and lymphocyte-induced vascular responses.

1987 • 491 citations

Identification of an Inhibitor of Neovascularization from Cartilage

1990 • 481 citations

Biologic Therapy of Cancer

1992 • 476 citations

Regulation of the activity of a new inhibitor of angiogenesis by a cancer suppressor gene

1989 • 475 citations

Treatment of Pulmonary Hemangiomatosis with Recombinant Interferon Alfa-2a

1989 • 444 citations

Minocycline reduces gingival collagenolytic activity during diabetes

1983 • 415 citations

Drug delivery to the central nervous system: A review

1992 • 371 citations

Inhibition of tumor angiogenesis mediated by cartilage.

1975 • 361 citations

Potent anti-angiogenic action of AGM-1470: comparison to the fumagillin parent

1991 • 324 citations

Tetracyclines inhibit tissue collagenase activity

1984 • 318 citations

Isolations of a Cartilage Factor That Inhibits Tumor Neovascularization

1976 • 308 citations

A Non-antibacterial Chemically-modified Tetracycline Inhibits Mammalian Collagenase Activity

1987 • 307 citations

Analytical profiles of drug substances

1972 • 306 citations

Control of Angiogenesis with Synthetic Heparin Substitutes

1989 • 292 citations

Tumor Angiogenesis: A Possible Control Point in Tumor Growth

1975 • 277 citations

Thrombospondin exerts an antiangiogenic effect on cord formation by endothelial cells in vitro.

1991 • 273 citations

Suppression of solid tumor growth by immunoneutralizing monoclonal antibody against human basic fibroblast growth factor.

1991 • 268 citations

Angiostatic Steroids

1987 • 267 citations

Antiangiogenic agents potentiate cytotoxic cancer therapies against primary and metastatic disease.

1992 • 259 citations

Angiogenesis inhibition by minocycline.

1991 • 254 citations

Polymers for Sustained Macromolecule Release: Procedures to Fabricate Reproducible Delivery Systems and Control Release Kinetics

1980 • 254 citations

Inhibition of angiogenesis through modulation of collagen metabolism.

1988 • 240 citations

Avascular and vascular phases of tumour growth in the chick embryo

1977 • 225 citations

Further evidence that tetracyclines inhibit collagenase activity in human crevicular fluid and from other mammalian sources

1985 • 215 citations

A Possible Mechanism for Inhibition of Angiogenesis by Angiostatic Steroids: Induction of Capillary Basement Membrane Dissolution*

1986 • 214 citations

Specific inhibition of endothelial cell proliferation by thrombospondin

1990 • 168 citations

Inhibition of tumor growth and metastasis of rodent tumors by the angiogenesis inhibitor O-(chloroacetyl-carbamoyl)fumagillol (TNP-470; AGM-1470).

1993 • 164 citations

Control of tumor growth in animals by infusion of an angiogenesis inhibitor.

1980 • 154 citations

Induction of angiogenesis in chick yolk-sac membrane by polyamines and its inhibition by tissue inhibitors of metalloproteinases (TIMP and TIMP-2)

1990 • 154 citations

Mechanism of action of angiostatic steroids: Suppression of plasminogen activator activity via stimulation of plasminogen activator inhibitor synthesis

1993 • 144 citations

A highly potent antiangiogenic activity of retinoids

1989 • 143 citations

Inhibition of tumor growth, vascularization, and collagenolysis in the rabbit cornea by medroxyprogesterone.

1981 • 136 citations

The resistance of certain tissues to invasion: penetrability of explanted tissues by vascularized mesenchyme.

1973 • 135 citations

Inhibition of Neovascularization by an Extract Derived from Vitreous

1977 • 132 citations

Biocompatibility of polymeric delivery systems for macromolecules

1981 • 128 citations

Inhibition of human endothelial cell proliferation in vitro and neovascularization in vivo by D-penicillamine.

1989 • 123 citations

Inhibition of angiogenesis by vitamin D3 analogues

1990 • 122 citations

Inhibition of angiogenesis and growth of human nerve-sheath tumors by AGM-1470

1993 • 85 citations

The role of minocycline in the treatment of intracranial 9L glioma

1995 • 83 citations

Inhibition of in vitro angiogenesis by lymphotoxin and interferon-γ

1988 • 81 citations

Tumor Angiogenesis and Polyamines: α-Difluoromethylornithine, an Irreversible Inhibitor of Ornithine Decarboxylase, Inhibits B16 Melanoma-induced Angiogenesis in Ovo and the Proliferation of Vascular Endothelial Cells in Vitro

1990 • 80 citations

Growth inhibition of the 9L glioma using polymers to release heparin and cortisone acetate

1990 • 73 citations

Inhibition of human endothelial cell proliferation by gold compounds.

1987 • 66 citations

The mitochondrial genetic system as a target for chemotherapy: Tetracyclines as cytostatics

1984 • 63 citations

Inhibition of basement membrane biosynthesis prevents angiogenesis.

1988 • 61 citations

Purification and partial amino acid sequence of a bovine cartilage-derived collagenase inhibitor.

1986 • 61 citations

Selective endothelial growth inhibition by tetracyclines that inhibit collagenase

1992 • 60 citations

Minocycline in combination with chemotherapy or radiation therapy in vitro and in vivo

1992 • 55 citations

Vascularization of the condylar cartilage of the human mandible.

1965 • 54 citations

Eponemycin, a novel antibiotic, is a highly powerful angiogenesis inhibitor

1991 • 54 citations

Medroxyprogesterone acetate, an anti‐cancer and anti‐angiogenic steroid, inhibits the plasminogen activator in bovine endothelial cells

1989 • 53 citations

Use of Flurbiprofen to Inhibit Corneal Neovascularization

1980 • 53 citations

Tumor angiogenesis inhibition by prostaglandin synthetase inhibitors.

1986 • 53 citations

Heparin-steroid conjugates: new angiogenesis inhibitors with antitumor activity in mice.

1993 • 52 citations

Chemical Modification of Fumagillin. I. 6-O-Acyl, 6-O-Sulfonyl, 6-O-Alkyl, and 6-O-(N-Substituted-carbamoyl)fumagillols.

1992 • 50 citations

Powerful antiangiogenic activity of herbimycin A (named angiostatic antibiotic).

1989 • 47 citations

Effects of prostaglandin synthesis inhibitors on tumor growth and vascularization. Experimental studies in the rat.

1983 • 42 citations

Inhibition of production of macrophage-derived angiogenic activity by the anti-rheumatic agents gold sodium thiomalate and auranofin

1988 • 42 citations

Inhibition of growth and angiogenesis of human neurofibrosarcoma by heparin and hydrocortisone

1990 • 40 citations

Antiangiogenic action of heparin plus cortisone is associated with decreased collagenous protein synthesis in the chick chorioallantoic membrane system.

1989 • 37 citations

Angiogenesis inhibitors and their delivery systems

1983 • 36 citations

THE VASCULAR PATTERN OF A GROWING AND FULLGROWN HUMAN EPIPHYSIS

1962 • 35 citations

HPLC determination of a chemically modified nonantimicrobial tetracycline: Biological implications

1992 • 25 citations

Vitreous: Inhibitor retinal extract induced neovascularization

1984 • 19 citations

Basement membrane biosynthesis as a target to tumor therapy.

1990 • 19 citations

Chemical Modification of Fumagillin. II. 6-Amino-6-deoxyfumagillol and Its Derivatives.

1992 • 17 citations

Antitumour Effects of Indomethacin Alone and in Combination with Radiotherapy: Role of Inhibition of Tumour Angiogenesis

1991 • 16 citations

Effect of 15-deoxyspergualin, a microbial angiogenesis inhibitor, on the biological activities of bovine vascular endothelial cells

1992 • 14 citations

The mode of action of anti-angiogenic steroid and heparin

1992 • 8 citations

Angiogenesis and heparin mimics

1992 • 7 citations