The mechanism of cancer-mediated conversion of plasminogen to the angiogenesis inhibitor angiostatin

Tumor Angiogenesis and Metastasis — Correlation in Invasive Breast Carcinoma

1991 • 5,657 citations

Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth

1997 • 4,504 citations

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

1993 • 3,605 citations

Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma

1994 • 3,367 citations

Induction of angiogenesis during the transition from hyperplasia to neoplasia

1989 • 1,912 citations

Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression

1995 • 1,863 citations

Angiostatin induces and sustains dormancy of human primary tumors in mice

1996 • 1,193 citations

A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin.

1990 • 1,062 citations

The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth

1994 • 743 citations

Macrophage-Derived Metalloelastase Is Responsible for the Generation of Angiostatin in Lewis Lung Carcinoma

1997 • 537 citations

Regulation of the activity of a new inhibitor of angiogenesis by a cancer suppressor gene

1989 • 475 citations

A model of angiogenesis in the mouse cornea.

1996 • 411 citations

Captopril inhibits angiogenesis and slows the growth of experimental tumors in rats.

1996 • 327 citations

The 16-kilodalton N-terminal fragment of human prolactin is a potent inhibitor of angiogenesis.

1993 • 321 citations

Inhibition of angiogenesis and tumor growth in the brain. Suppression of endothelial cell turnover by penicillamine and the depletion of copper, an angiogenic cofactor.

1990 • 230 citations

Human prostate carcinoma cells express enzymatic activity that converts human plasminogen to the angiogenesis inhibitor, angiostatin.

1996 • 199 citations

A potent inhibitor of endothelial cell proliferation is generated by proteolytic cleavage of the chemokine platelet factor 4.

1995 • 143 citations

HYPERCOAGULABILITY IN CANCER

1996 • 137 citations

Inhibition of human endothelial cell proliferation in vitro and neovascularization in vivo by D-penicillamine.

1989 • 123 citations

Inhibition of human endothelial cell proliferation by gold compounds.

1987 • 66 citations

Inhibition of endothelial cell proliferation by SPARC is mediated through a Ca²⁺‐binding EF‐hand sequence

1995 • 66 citations

Plasminogen Activators and Angiogenesis

1996 • 42 citations

Activation of Human Plasminogen by Staphylokinase. Direct Evidence That Preformed Plasmin Is Necessary for Activation to Occur

1997 • 40 citations

Activation of Human Plasminogen by Staphylokinase. Direct Evidence That Preformed Plasmin Is Necessary for Activation to Occur

1997 • 40 citations

Thiol-containing compounds inhibit the production of monocyte/macrophage-derived angiogenic activity

1991 • 29 citations

Relationship between circulating plasminogen activators and tumor development in mice.

1986 • 21 citations