Accelerated apoptosis in peripheral blood mononuclear cells (PBMCs) from human immunodeficiency virus type-1 infected patients and in CD4 cross-linked PBMCs from normal individuals

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1991 • 4,682 citations

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

Features of apoptotic cells measured by flow cytometry

1992 • 1,912 citations

HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease

1993 • 1,822 citations

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis

1989 • 1,739 citations

Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS

1993 • 1,450 citations

Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures

1989 • 1,159 citations

Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products

1992 • 1,103 citations

lnterleukin-2 programs mouse αβ T lymphocytes for apoptosis

1991 • 1,027 citations

Phagocyte recognition of cells undergoing apoptosis

1993 • 1,000 citations

Programmed Death of T Cells in HIV-1 Infection

1992 • 932 citations

Activation-induced death by apoptosis in CD4+ T cells from human immunodeficiency virus-infected asymptomatic individuals.

1992 • 907 citations

Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis.

1992 • 689 citations

Programmed cell death and extrathymic reduction of Vβ8+CD4+ T cells in mice tolerant to Staphylococcus aureus enterotoxin B

1991 • 675 citations

Endogenous endonuclease-induced DNA fragmentation: an early event in cell-mediated cytolysis.

1983 • 616 citations

Cell dysfunction and depletion in AIDS: the programmed cell death hypothesis

1991 • 548 citations

Differential expression of apoptosis-related Fas antigen on lymphocyte subpopulations in human peripheral blood.

1992 • 510 citations

Death of mature T cells by separate ligation of CD4 and the T-cell receptor for antigen

1990 • 375 citations

Lymphocyte subsets in the blood: a diagnostic window on the lymphoid system?

1990 • 350 citations

Lymphoid Germinal Centers Are Reservoirs of Human Immunodeficiency Virus Type 1 RNA

1991 • 301 citations

Immunopathogenic mechanisms of HIV infection: cytokine induction of HIV expression

1990 • 290 citations

Characteristics of a monoclonal antibody (WT-31) that recognizes a common epitope on the human T cell receptor for antigen.

1985 • 240 citations

Identification of HIV-1 Envelope Glycoprotein in the Serum of AIDS and ARC Patients

1992 • 234 citations

Follicular dendritic cells are a major reservoir for human immunodeficiency virus type 1 in lymphoid tissues facilitating infection of CD4+ T-helper cells.

1992 • 231 citations

Bcl-2: a repressor of lymphocyte death

1992 • 217 citations

Apoptosis in interleukin-3-dependent haemopoietic cells

1992 • 207 citations

Transforming growth factor beta and noncytopathic mechanisms of immunodeficiency in human immunodeficiency virus infection.

1990 • 194 citations

Lymphocyte subsets in the blood: a diagnostic window on the lymphoid

1990 • 192 citations

The HIV-1 gp120 envelope protein has the intrinsic capacity to stimulate monokine secretion.

1991 • 168 citations

DNA fragmentation: manifestation of target cell destruction mediated by cytotoxic T-cell lines, lymphotoxin-secreting helper T-cell clones, and cell-free lymphotoxin-containing supernatant.

1986 • 152 citations

Superantigen implicated in dependence of HIV-1 replication in T cells on TCR V β expression

1992 • 152 citations

Transforming growth factor beta 1 induces apoptotic cell death in cultured human gastric carcinoma cells.

1992 • 152 citations

Human immunodeficiency virus type 1 envelope glycoprotein gp120 produces immune defects in CD4+ T lymphocytes by inhibiting interleukin 2 mRNA.

1990 • 148 citations

Anti-Fas monoclonal antibody is cytocidal to human immunodeficiency virus-infected cells without augmenting viral replication.

1990 • 127 citations

Inhibition of functional properties of tetanus antigen-specific T-cell clones by envelope glycoprotein GP120 of human immunodeficiency virus

1990 • 112 citations

AIDS pathogenesis: HIV envelope and its interaction with cell proteins

1990 • 92 citations

CD4 epitope masking by gp120/anti-gp120 antibody complexes. A potential mechanism for CD4+ cell function down-regulation in AIDS patients.

1992 • 82 citations

Expansion and clonal deletion of peripheral T cells induced by bacterial superantigen is independent of the interleukin‐2 pathway

1992 • 70 citations

Autoantibodies against CD4 cells are associated with CD4 helper defects in human immunodeficiency virus-infected patients

1991 • 62 citations

The pathobiology of HIV infection

1992 • 61 citations

Human immunodeficiency virus type 1 envelope glycoproteins gp120 and gp160 induce interleukin-6 production in CD4+ T-cell clones

1991 • 60 citations

A flow-cytometric method to study DNA fragmentation in lymphocytes

1992 • 31 citations

Role of CD4 molecule in the induction of interleukin 2 and interleukin 2 receptor in class II major histocompatibility complex-restricted antigen-specific T helper clones. T cell receptor/CD3 complex transmits CD4-dependent and CD4-independent signals.

1992 • 20 citations

Factors and Mechanisms of AIDS Pathogenesis1

2015 • 10 citations