Macrophage-tropic HIV: critical for AIDS pathogenesis?

The Role of Mononuclear Phagocytes in HTLV-III/LAV Infection

1986 • 1,828 citations

HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease

1993 • 1,822 citations

Detection of AIDS Virus in Macrophages in Brain Tissue from AIDS Patients with Encephalopathy

1986 • 1,694 citations

Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS

1993 • 1,450 citations

Genotypic and Phenotypic Characterization of HIV-1 Patients with Primary Infection

1993 • 1,258 citations

Efficient isolation and propagation of human immunodeficiency virus on recombinant colony-stimulating factor 1-treated monocytes.

1988 • 785 citations

High Titers of Cytopathic Virus in Plasma of Patients with Symptomatic Primary HIV-1 Infection

1991 • 697 citations

Differential syncytium-inducing capacity of human immunodeficiency virus isolates: frequent detection of syncytium-inducing isolates in patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex

1988 • 621 citations

Macrophage-tropic human immunodeficiency virus isolates from different patients exhibit unusual V3 envelope sequence homogeneity in comparison with T-cell-tropic isolates: definition of critical amino acids involved in cell tropism

1992 • 594 citations

HIV-1 tropism for mononuclear phagocytes can be determined by regions of gp120 outside the CD4-binding domain

1990 • 589 citations

Cellular Proteins Bound to Immunodeficiency Viruses: Implications for Pathogenesis and Vaccines

1992 • 570 citations

Macrophage and T cell-line tropisms of HIV-1 are determined by specific regions of the envelope gp!20 gene

1991 • 525 citations

Increased viral burden and cytopathicity correlate temporally with CD4+ T-lymphocyte decline and clinical progression in human immunodeficiency virus type 1-infected individuals

1993 • 464 citations

Extensive variation of human immunodeficiency virus type-1 in vivo

1988 • 415 citations

HIV induces thymus depletion in vivo

1993 • 384 citations

Macrophage tropism determinants of human immunodeficiency virus type 1 in vivo

1992 • 292 citations

The SCID-hu mouse as a model for HIV-1 infection

1993 • 288 citations

Human Immunodeficiency Virus Infection of Human-PBL-SCID Mice

1991 • 277 citations

Signature Pattern Analysis: A Method for Assessing Viral Sequence Relatedness

1992 • 239 citations

Functional and phenotypic evidence for a selective loss of memory T cells in asymptomatic human immunodeficiency virus-infected men.

1990 • 198 citations

Rapid Loss of CD4 ⁺ T Cells in Human-PBL-SCID Mice by Noncytopathic HIV Isolates

1993 • 189 citations

AIDS pathogenesis: a dynamic interaction between HIV and the immune system

1990 • 129 citations

Human immunodeficiency virus type 1 cellular host range, replication, and cytopathicity are linked to the envelope region of the viral genome

1990 • 124 citations

The viral envelope gene is involved in macrophage tropism of a human immunodeficiency virus type 1 strain isolated from brain tissue

1990 • 113 citations

Lack of T Cell Dysfunction and Programmed Cell Death in Human Immunodeficiency Virus Type 1-Infected Chimpanzees Correlates with Absence of Monocytotropic Variants

1993 • 105 citations

A Cross-Sectional Comparison of Persons with Syncytium- and Non-Syncytium-Inducing Human Immunodeficiency Virus

1993 • 92 citations

Mononuclear Phagocytes as Targets, Tissue Reservoirs, and Immunoregulatory Cells in Human Immunodeficiency Virus Disease

1992 • 87 citations

HIV genome variability in vivo

1989 • 86 citations

The Role of Monocyte/Macrophages and Cytokines in the Pathogenesis of HIV Infection

1992 • 75 citations

MT-4 plaque formation can distinguish cytopathic subtypes of the human immunodeficiency virus (HIV)

1988 • 63 citations

Secretory Repertoire of HIV-Infected Human Monocytes/Macrophages

1991 • 54 citations

Linkage between immune response potential to DNA and X chromosome

1974 • 50 citations

Simulation of HIV infection in artificial immune systems

1990 • 46 citations

Biologic heterogeneity of human immunodeficiency virus type 2 (HIV-2) strains

1990 • 43 citations

HIV-1 Intrapatient Sequence Diversity in the Immunogenic V3 Region

1992 • 31 citations

Effect of HIV on antigen presentation by dendritic cells and macrophages

1991 • 26 citations

Quantitative Differences In Phagocytosis and Degradation of Pneumocystis By Alveolar Macrophages In Aids and Non‐Hiv Patients In Vivo

1993 • 21 citations

The cellular device machine: Point of departure for large-scale simulations of complex biological systems

1990 • 10 citations