Microtubule Disruption Utilizes an NFκB-dependent Pathway to Stabilize HIF-1α Protein

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

1995 • 5,971 citations

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O ₂ -Regulated Prolyl Hydroxylation

2001 • 5,255 citations

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O ₂ Sensing

2001 • 4,537 citations

Activators and Target Genes of Rel/NF-кB Transcription Factors

2003 • 3,164 citations

A rapid micrqpreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells

1991 • 2,362 citations

IκB: a Specific Inhibitor of the NF-κB Transcription Factor

1988 • 2,203 citations

Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases.

1999 • 2,168 citations

Regulation of hypoxia-inducible factor 1α is mediated by an O ₂ -dependent degradation domain via the ubiquitin-proteasome pathway

1998 • 2,044 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

Hypoxia-inducible Factor 1α (HIF-1α) Protein Is Rapidly Degraded by the Ubiquitin-Proteasome System under Normoxic Conditions

1997 • 1,610 citations

Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics.

2000 • 1,430 citations

Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB

1993 • 1,129 citations

Hypoxia-inducible factor 1: master regulator of O2 homeostasis

1998 • 1,066 citations

Hypoxia Inducible Factor-α Binding and Ubiquitylation by the von Hippel-Lindau Tumor Suppressor Protein

2000 • 1,018 citations

Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli.

1995 • 1,010 citations

Mechanism of regulation of the hypoxia-inducible factor-1alpha by the von Hippel-Lindau tumor suppressor protein

2000 • 889 citations

Insulin-like Growth Factor 1 Induces Hypoxia-inducible Factor 1-mediated Vascular Endothelial Growth Factor Expression, Which is Dependent on MAP Kinase and Phosphatidylinositol 3-Kinase Signaling in Colon Cancer Cells

2002 • 807 citations

The Cytoskeleton and Cell Signaling: Component Localization and Mechanical Coupling

1998 • 783 citations

Hsp90 Regulates a von Hippel Lindau-independent Hypoxia-inducible Factor-1α-degradative Pathway

2002 • 633 citations

Microtubules and actin filaments: dynamic targets for cancer chemotherapy

1998 • 614 citations

Expression of hypoxia-inducible factor 1? in brain tumors

2000 • 596 citations

Blockade of NF-κB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis

2001 • 545 citations

Insulin Stimulates Hypoxia-inducible Factor 1 through a Phosphatidylinositol 3-Kinase/Target of Rapamycin-dependent Signaling Pathway

2002 • 527 citations

Multiple signals converging on NF-κB

1999 • 483 citations

Nuclear transcription factor-κB as a target for cancer drug development

2002 • 437 citations

In VivoExpression of mRNAs Encoding Hypoxia-Inducible Factor 1

1996 • 412 citations

Microtubules and signal transduction

1999 • 407 citations

The effect of antimicrotubule agents on signal transduction pathways of apoptosis: a review

1999 • 375 citations

Microtubule-interfering Agents Activate c-Jun N-terminal Kinase/Stress-activated Protein Kinase through Both Ras and Apoptosis Signal-regulating Kinase Pathways

1998 • 353 citations

p53 is associated with cellular microtubules and is transported to the nucleus by dynein

2000 • 352 citations

Direct observation of microtubule dynamics in living cells

1988 • 318 citations

The clinical pharmacology and use of antimicrotubule agents in cancer chemotherapeutics

1991 • 313 citations

Microtubule-interfering Agents Stimulate the Transcription of Cyclooxygenase-2

2000 • 301 citations

Paclitaxel sensitivity of breast cancer cells with constitutively active NF-κB is enhanced by IκBα super-repressor and parthenolide

2000 • 290 citations

Cytoskeletal control of gene expression: depolymerization of microtubules activates NF-kappa B.

1995 • 276 citations

Activation of NF-κB by Antineoplastic Agents

1997 • 271 citations

NF-??B Activation and Inhibition: A Review

2002 • 258 citations

Coordinate up-regulation of hypoxia inducible factor (HIF)-1alpha and HIF-1 target genes during multi-stage epidermal carcinogenesis and wound healing.

2000 • 233 citations

Nuclear factor-kappaB p65 (RelA) transcription factor is constitutively activated in human gastric carcinoma tissue.

2001 • 211 citations

Mechanism of action of a dominant-negative mutant of c-Jun.

1994 • 207 citations

CHO mutants resistant to colchicine, colcemid or griseofulvin have an altered β-tubulin

1980 • 201 citations

Functional Requirement of the Hypoxia-responsive Element in the Activation of the Inducible Nitric Oxide Synthase Promoter by the Iron Chelator Desferrioxamine

1997 • 197 citations

Inhibition of NF-κB Activity Decreases the VEGF mRNA Expression in MDA-MB-231 Breast Cancer Cells

2002 • 167 citations

Induction of Phosphoglycerate Kinase 1 Gene Expression by Hypoxia

1996 • 162 citations

Dynamic instability of microtubules

1987 • 162 citations

Expression of p53, inducible nitric oxide synthase and vascular endothelial growth factor in gastric precancerous and cancerous lesions: correlation with clinical features

2002 • 125 citations

Physiochemical Aspects of Tubulin-Interacting Antimitotic Drugs

2001 • 105 citations

Transcriptional activation function of the mouse Ah receptor nuclear translocator.

1994 • 101 citations

Role of HIF-1 as a transcription factor involved in embryonic development, cancer progression and apoptosis (review).

2000 • 90 citations

Enhanced Invasion and Liver Colonization by Lung Carcinoma Cells Overexpressing the Type 1 Insulin-Like Growth Factor Receptor

1998 • 86 citations

Protein Kinase C Induces Motility of Breast Cancers by Upregulating Secretion of Urokinase-Type Plasminogen Activator through Activation of AP-1 and NF-κB

2002 • 81 citations

Disruption of cytoskeletal structures results in the induction of the urokinase-type plasminogen activator gene expression.

1990 • 76 citations

Microtubule Integrity Regulates Src-like and Extracellular Signal-regulated Kinase Activities in Human Pro-monocytic Cells

1998 • 70 citations

Involvement of Nuclear Factor κB in c-Myc Induction by Tubulin Polymerization Inhibitors

2001 • 55 citations

Protein Kinase Cδ-dependent Induction of Manganese Superoxide Dismutase Gene Expression by Microtubule-active Anticancer Drugs

1998 • 54 citations

Taxol selectively blocks microtubule dependent NF-κB activation by phorbol ester via inhibition of IκBα phosphorylation and degradation

1999 • 53 citations

Recent Advances in Understanding NF-κB Regulation

2002 • 50 citations

Stimulation of human interleukin 1 production and specific mRNA expression by microtubule-disrupting drugs

1990 • 32 citations

Transfer and amplification of a mutant beta-tubulin gene results in colcemid dependence: use of the transformant to demonstrate regulation of beta-tubulin subunit levels by protein degradation.

1986 • 26 citations

Role of the cytoskeleton in adhesion stabilization of human colorectal carcinoma cells to extracellular matrix components under dynamic conditions of laminar flow.

1999 • 22 citations

The influence of microtubule integrity on plasma membrane fluidity in L929 cells

2000 • 13 citations

[Involvement of FAK, PI3-K and PKC in cell adhesion induced by microtubule disruption].

2002 • 3 citations