Functional Requirement of the Hypoxia-responsive Element in the Activation of the Inducible Nitric Oxide Synthase Promoter by the Iron Chelator Desferrioxamine

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

The L-Arginine-Nitric Oxide Pathway

1993 • 6,737 citations

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

1995 • 5,971 citations

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1992 • 4,631 citations

Nitric oxide as a secretory product of mammalian cells

1992 • 4,437 citations

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.

1992 • 2,420 citations

Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase.

1994 • 2,216 citations

Cloning and Characterization of Inducible Nitric Oxide Synthase from Mouse Macrophages

1992 • 1,914 citations

Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.

1994 • 1,821 citations

Regulation of biosynthesis of nitric oxide.

1994 • 1,698 citations

Role of nitric oxide synthesis in macrophage antimicrobial activity

1991 • 1,547 citations

General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.

1993 • 1,441 citations

Erythropoietin: structure, control of production, and function

1992 • 1,158 citations

Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide.

1993 • 1,127 citations

Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide.

1993 • 1,077 citations

Regulation of the Erythropoietin Gene: Evidence That the Oxygen Sensor Is a Heme Protein

1988 • 1,042 citations

Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene.

1991 • 932 citations

Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line.

1992 • 877 citations

Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia.

1993 • 857 citations

Requirement for Transcription Factor IRF-1 in NO Synthase Induction in Macrophages

1994 • 840 citations

Desferrioxamine induces erythropoietin gene expression and hypoxia- inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction

1993 • 740 citations

Intramuscular desferrioxamine in patients with Alzheimer's disease

1991 • 723 citations

A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter.

1995 • 630 citations

Expression of the nitric oxide synthase gene in mouse macrophages activated for tumor cell killing. Molecular basis for the synergy between interferon-gamma and lipopolysaccharide.

1993 • 623 citations

Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin.

1994 • 584 citations

Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer.

1994 • 517 citations

Role of interferon regulatory factor 1 in induction of nitric oxide synthase.

1994 • 477 citations

Iron regulates nitric oxide synthase activity by controlling nuclear transcription.

1994 • 413 citations

Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism.

1993 • 411 citations

Expression of nitric oxide synthase in human central nervous system tumors.

1995 • 370 citations

Selective immortalization of murine macrophages from fresh bone marrow by a raf/myc recombinant murine retrovirus

1985 • 246 citations

Quantitation of human immunodeficiency virus, immune activation factors, and quinolinic acid in AIDS brains.

1993 • 205 citations

Heterogeneity of Hematopoietic Cells Immortalized by v-myc/v-raf Recombinant Retrovirus Infection of Bone Marrow or Fetal Liver

1989 • 132 citations

Regulation of nitric-oxide synthase mRNA expression by interferon-gamma and picolinic acid.

1994 • 119 citations

Regulation of inducible nitric oxide synthase expression in IFN-gamma-treated murine macrophages cultured under hypoxic conditions.

1996 • 107 citations

Poliovirus induces indoleamine‐2,3‐dioxygenase and quinolinic acid synthesis in macaque brain

1992 • 98 citations

Altered tryptophan and neopterin metabolism in cancer patients treated with recombinant interleukin 2.

1989 • 82 citations

Gene Expression in Low Oxygen Tension

1993 • 79 citations

Chelation therapy in beta-thalassemia: the benefits and limitations of desferrioxamine.

1995 • 74 citations

Deferoxamine followed by cyclophosphamide, etoposide, carboplatin, thiotepa, induction regimen in advanced neuroblastoma: Preliminary results

1995 • 70 citations

Picolinic acid, a catabolite of L-tryptophan, is a costimulus for the induction of reactive nitrogen intermediate production in murine macrophages.

1993 • 70 citations

Deferoxamine in children with recurrent neuroblastoma.

1994 • 70 citations

Picolinic acid, a catabolite of tryptophan, as the second signal in the activation of IFN-gamma-primed macrophages.

1990 • 69 citations

Control of growth by picolinic acid: Differential response of normal and transformed cells

1977 • 68 citations

Iron: Possible cause of the G1 arrest induced in NRK cells by picolinic acid

1977 • 54 citations

A predictor for side effects in patients with Alzheimer's disease treated with deferoxamine mesylate

1993 • 28 citations

Phase I study using desferrioxamine and iron sorbitol citrate in an attempt to modulate the iron status of tumor cells to enhance doxorubicin activity

1993 • 28 citations

Transfection of DNA into adherent cells by DEAE-dextran/DMSO method increases drastically if the ceils are removed from surface and treated in suspension

1989 • 26 citations