Disruption of cytoskeletal structures results in the induction of the urokinase-type plasminogen activator gene expression.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Plasminogen Activators, Tissue Degradation, and Cancer

1985 • 2,584 citations

Role of cell shape in growth control

1978 • 2,434 citations

Human Proto-Oncogene c- jun Encodes a DNA Binding Protein with Structural and Functional Properties of Transcription Factor AP-1

1987 • 1,353 citations

Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression.

1989 • 1,073 citations

THE MECHANISM OF ACTION OF COLCHICINE

1967 • 1,049 citations

A study of proteases and protease-inhibitor complexes in biological fluids

1978 • 810 citations

Mechanism of action of cytochalasin B on actin

1980 • 732 citations

The origin and characteristics of a pig kidney cell strain, LLC-PK1

1976 • 604 citations

Stromelysin, a connective tissue-degrading metalloendopeptidase secreted by stimulated rabbit synovial fibroblasts in parallel with collagenase. Biosynthesis, isolation, characterization, and substrates.

1985 • 506 citations

Fibronectin modulation of cell shape and lipogenic gene expression in 3t3-adipocytes

1983 • 432 citations

Cytochalasins block actin filament elongation by binding to high affinity sites associated with F-actin.

1980 • 430 citations

Relationships between fibronectin (LETS protein) and actin

1978 • 428 citations

The effects of methyl (5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl) carbamate, (R 17934; NSC 238159), a new synthetic antitumoral drug interfering with microtubules, on mammalian cells cultured in vitro.

1976 • 422 citations

THE MECHANISM OF COLCHICINE INHIBITION OF MITOSIS

1965 • 419 citations

Messenger RNA is translated when associated with the cytoskeletal framework in normal and VSV-infected HeLa cells

1981 • 403 citations

Cloning and characterization of different human sequences related to the onc gene (v-myc) of avian myelocytomatosis virus (MC29).

1982 • 348 citations

Isolation of the oncogene and epidermal growth factor-induced transin gene: complex control in rat fibroblasts.

1986 • 339 citations

Decreases in tubulin and actin gene expression prior to morphological differentiation of 3T3 Adipocytes

1982 • 304 citations

A tumor promoter induces rapid and coordinated reorganization of actin and vinculin in cultured cells.

1984 • 303 citations

Cytochalasin B and the structure of actin gels

1979 • 234 citations

Drosophila DNA topoisomerase I is associated with transcriptionally active regions of the genome.

1984 • 225 citations

Modulation of metastatic potential by cell surface urokinase of murine melanoma cells.

1988 • 223 citations

Molecular species of plasminogen activators secreted by normal and neoplastic human cells.

1980 • 202 citations

Evidence that microtubule depolymerization early in the cell cycle is sufficient to initiate DNA synthesis

1981 • 202 citations

Cytochalasin releases mRNA from the cytoskeletal framework and inhibits protein synthesis.

1986 • 174 citations

Differentiation-dependent chromatin alterations precede and accompany transcription of immunoglobulin light chain genes.

1984 • 167 citations

Commitment to expression of the metalloendopeptidases, collagenase and stromelysin: relationship of inducing events to changes in cytoskeletal architecture.

1986 • 165 citations

Actin-containing cables within anchorage-dependent rat embryo cells are dissociated by plasmin and trypsin

1975 • 154 citations

Hormonal regulation of plasminogen activator mRNA production in porcine kidney cells

1983 • 151 citations

Limited cleavage of cellular fibronectin by plasminogen activator purified from transformed cells.

1987 • 147 citations

Structure and expression in L-cells of a cloned H4 histone gene of the mouse

1981 • 140 citations

The regulatory subunit of adenylate cyclase interacts with cytoskeletal components

1981 • 129 citations

Sequences coding for part of oncogene-induced transin are highly conserved in a related rat gene

1987 • 127 citations

Inhibition of protein synthesis stabilizes histone mRNA.

1984 • 122 citations

cDNA and gene nucleotide sequence of porcine plasminogen activator

1984 • 116 citations

Induction and desensitization of plasminogen activator gene expression by tumor promoters.

1985 • 103 citations

Proteases induce secretion of collagenase and plasminogen activator by fibroblasts

1978 • 102 citations

Rapid reversible changes in the rate of histone gene transcription and histone mRNA levels in mouse myeloma cells.

1984 • 100 citations

Dihydrocytochalasin B disorganizes actin cytoarchitecture and inhibits initiation of DNA synthesis in 3T3 cells

1982 • 100 citations

Modulation of the Metastatic Capability in B16 Melanoma by Cell Shape

1983 • 97 citations

The relationship between cytoplasmic organization, gene expression and morphogenesis

1986 • 93 citations

cAMP mediated proteolysis of the catalytic subunit of cAMP‐dependent protein kinase

1986 • 74 citations

Chromosomal Locations of Human Tissue Plasminogen Activator and Urokinase Genes

1985 • 72 citations

Induction of urokinase-type plasminogen activator by UV light in human fetal fibroblasts is mediated through a UV-induced secreted protein.

1987 • 69 citations

Inhibition of protein synthesis in LLC-PK1 cells increases calcitonin-induced plasminogen-activator gene transcription and mRNA stability

1987 • 64 citations

Fractionation of the beta subunit common to guanine nucleotide-binding regulatory proteins with the cytoskeleton.

1986 • 64 citations

Investigations of the possible functions for glycosylation in the high mobility group proteins. Evidence for a role in nuclear matrix association.

1983 • 61 citations

Colchicine potentiates β-adrenoreceptor-stimulated cyclic AMP in lymphoma cells by an action distal to the receptor

1978 • 60 citations

Modulation of plasminogen activator in rodent mammary tumors by hormones and other effectors.

1983 • 57 citations

Control of late Simian virus 40 transcription by the attenuation mechanism and transcriptionally active ternary complexes are associated with the nuclear matrix

1984 • 48 citations

Cytoskeleton structure and function

1984 • 43 citations

Cytoskeletal constraint of the beta-adrenergic receptor in frog erythrocyte membranes.

1980 • 42 citations

Identification of the cellular mechanisms responsible for platelet‐derived growth factor induced alterations in cytoplasmic vinculin distribution

1986 • 39 citations

Molecular complexes involved in the regulation of adenylate cyclase.

1981 • 39 citations

Tumor promoter and fibronectin induce actin stress fibers and focal adhesion sites in spreading human erythroleukemia (HEL) cells.

1987 • 29 citations

Dexamethasone coordinately inhibits plasminogen activator gene expression and enzyme activity in porcine kidney cells

1987 • 27 citations

Chromosomal assignments of genes for tissue plasminogen activator and urokinase in mouse

1987 • 23 citations

hsp70 mRNA accumulates in LLC-PK1 pig kidney cells treated with calcitonin but not with 8-bromo-cyclic AMP.

1988 • 23 citations

Studies on tissue culture produced plasminogen activator

1977 • 16 citations

The distribution of nuclear proteins and transcriptionally-active sequences in rat liver chromatin fractions

1986 • 13 citations

Staurosporine stimulates expression of the urokinase‐type (u‐PA) plasminogen activator in LLC‐PK₁ cells

1989 • 11 citations