Microtubule-interfering Agents Activate c-Jun N-terminal Kinase/Stress-activated Protein Kinase through Both Ras and Apoptosis Signal-regulating Kinase Pathways

Current protocols in molecular biology

1988 • 7,584 citations

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

AP-1 function and regulation

1997 • 2,833 citations

Cyclophosphamide and Cisplatin Compared with Paclitaxel and Cisplatin in Patients with Stage III and Stage IV Ovarian Cancer

1996 • 2,766 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

Mitogen-activated protein kinase pathways

1997 • 2,513 citations

Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways

1997 • 2,284 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1995 • 1,499 citations

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

1996 • 1,493 citations

Sounding the Alarm: Protein Kinase Cascades Activated by Stress and Inflammation

1996 • 1,099 citations

Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK

1994 • 1,092 citations

Ultraviolet Light and Osmotic Stress: Activation of the JNK Cascade Through Multiple Growth Factor and Cytokine Receptors

1996 • 1,046 citations

The Role of c-Jun N-terminal Kinase (JNK) in Apoptosis Induced by Ultraviolet C and γ Radiation

1996 • 881 citations

Paclitaxel-resistant Human Ovarian Cancer Cells Have Mutant β-Tubulins That Exhibit Impaired Paclitaxel-driven Polymerization

1997 • 668 citations

Taxol induces bcl-2 phosphorylation and death of prostate cancer cells.

1996 • 662 citations

Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis

1996 • 654 citations

JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation.

1994 • 639 citations

Bcl2 is the guardian of microtubule integrity.

1997 • 599 citations

Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages.

1996 • 475 citations

Synchronization of tumor and normal cells from G1 to multiple cell cycles by lovastatin.

1991 • 468 citations

Persistent Activation of c-Jun N-terminal Kinase 1 (JNK1) in γ Radiation-induced Apoptosis

1996 • 460 citations

Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras

1997 • 451 citations

Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase.

1996 • 414 citations

Bcl-2 Undergoes Phosphorylation by c-Jun N-terminal Kinase/Stress-activated Protein Kinases in the Presence of the Constitutively Active GTP-binding Protein Rac1

1997 • 406 citations

Synthesis of epothilones A and B in solid and solution phase

1997 • 397 citations

Cell cycle-dependent activation of Ras

1996 • 389 citations

Raf-1/bcl-2 phosphorylation: a step from microtubule damage to cell death.

1997 • 387 citations

The Dual Specificity Phosphatases M3/6 and MKP-3 Are Highly Selective for Inactivation of Distinct Mitogen-activated Protein Kinases

1996 • 385 citations

Three distinct signalling responses by murine fibroblasts to genotoxic stress

1996 • 359 citations

The Dual Specificity Mitogen-activated Protein Kinase Phosphatase-1 and -2 Are Induced by the p42/p44MAPK Cascade

1997 • 358 citations

Signal Transduction Pathways Regulated by Mitogen-activated/Extracellular Response Kinase Kinase Kinase Induce Cell Death

1996 • 346 citations

Vascular endothelial growth factor, placenta growth factor and their receptors in isolated human trophoblast

1997 • 331 citations

The regulation of AP-1 activity by mitogen-activated protein kinases

1996 • 312 citations

A non-enzymatic p21 protein inhibitor of stress-activated protein kinases

1996 • 248 citations

Peptidomimetic inhibitors of Ras farnesylation and function in whole cells.

1993 • 222 citations

c-Jun NH2-terminal Kinase-mediated Activation of Interleukin-1β Converting Enzyme/CED-3-like Protease during Anticancer Drug-induced Apoptosis

1997 • 207 citations

Taxol induction of p21WAF1 and p53 requires c-raf-1.

1995 • 187 citations

Molecular Cloning and Functional Characterization of a Novel Mitogen-activated Protein Kinase Phosphatase, MKP-4

1997 • 146 citations

Colchicine Induces Apoptosis in Cerebellar Granule Cells

1995 • 143 citations

Ras-Induced Activation of Raf-1 Is Dependent on Tyrosine Phosphorylation

1996 • 131 citations

Selective Activation of MEK1 but Not MEK2 by A-Raf from Epidermal Growth Factor-stimulated Hela Cells

1996 • 120 citations

Microtubule-active drugs taxol, vinblastine, and nocodazole increase the levels of transcriptionally active p53.

1995 • 120 citations

Ischemia and Reperfusion Enhance ATF-2 and c-Jun Binding to cAMP Response Elements and to an AP-1 Binding Site from the c-jun Promoter

1995 • 118 citations

Modulation of microtubule dynamics during the cell cycle

1996 • 107 citations

Apoptosis: Bcl-2-related proteins get connected

1997 • 100 citations

Characteristics of cancer cell death after exposure to cytotoxic drugs in vitro

1996 • 98 citations

Effect of UV-irradiation on cell cycle, viability and the expression of p53, gadd153 and gadd45 genes in normal and HPV-immortalized human oral keratinocytes.

1994 • 88 citations

Tyrosine 763 of the Murine Granulocyte Colony-Stimulating Factor Receptor Mediates Ras-Dependent Activation of the JNK/SAPK Mitogen-Activated Protein Kinase Pathway

1997 • 86 citations

Guidebook to the small GTPases

1997 • 84 citations

Complexes of p21RAS with JUN N-terminal kinase and JUN proteins.

1995 • 74 citations

Disruption of Microtubules Reveals Two Independent Apical Targeting Mechanisms for G-protein-coupled Receptors in Polarized Renal Epithelial Cells

1997 • 60 citations

Regulation of p42 Mitogen‐Activated‐Protein Kinase Activity by Protein Phosphatase 2A Under Conditions of Growth Inhibition by Epidermal Growth Factor in A431 Cells

1996 • 54 citations

Transformation by Raf and other oncogenes renders cells differentially sensitive to growth inhibition by a dominant negative c-jun mutant.

1994 • 54 citations

Reconstitution of novel signalling cascades responding to cellular stresses

1996 • 44 citations

Ras‐Dependent and Ras‐Independent Activation Pathways for the Stress‐Activated‐Protein‐Kinase Cascade

1996 • 43 citations

Human epithelial ovarian cancer cell steroid secretion and its control by gonadotropins

1991 • 42 citations

Guidebook to the small GTPases

1996 • 41 citations

Modulation of vinblastine cytotoxicity by dilantin (phenytoin) or the protein phosphatase inhibitor okadaic acid involves the potentiation of anti-mitotic effects and induction of apoptosis in human tumour cells

1996 • 32 citations

Expression, purification and characterization of recombinant mitogen-activated protein kinase kinases

1994 • 31 citations

Is taxol a surrogate for a universal regulator of mitosis?

1994 • 16 citations

The steroidogenic and morphological effects of paclitaxel on cultured ovarian cancer cells.

1995 • 6 citations