Chapter 18 Expression of nitric oxide synthase-2 in glia associated with CNS pathology

Reversible middle cerebral artery occlusion without craniectomy in rats.

1989 • 6,875 citations

Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines.

1995 • 1,762 citations

Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide Synthase

1994 • 1,578 citations

Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase

1995 • 1,454 citations

Molecular profile of reactive astrocytes—Implications for their role in neurologic disease

1993 • 1,436 citations

Pathophysiology and treatment of focal cerebral ischemia

1992 • 1,287 citations

Nitric Oxide Synthases: Properties and Catalytic Mechanism

1995 • 1,275 citations

Bright and dark sides of nitric oxide in ischemic brain injury

1997 • 1,043 citations

Inducible nitric oxide synthase: what difference does it make?

1997 • 964 citations

Cytokines in inflammatory brain lesions: helpful and harmful

1996 • 727 citations

Induction and Stabilization of IκBα by Nitric Oxide Mediates Inhibition of NF-κB

1995 • 707 citations

Delayed Reduction of Ischemic Brain Injury and Neurological Deficits in Mice Lacking the Inducible Nitric Oxide Synthase Gene

1997 • 655 citations

Nitric Oxide Measured by a Porphyrinic Micro Sensor in Rat Brain after Transient Middle Cerebral Artery Occlusion

1993 • 632 citations

Synthesis of nitric oxide in CNS glial cells

1993 • 627 citations

Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E

1997 • 601 citations

Nitric oxide regulates vascular cell adhesion molecule 1 gene expression and redox-sensitive transcriptional events in human vascular endothelial cells.

1996 • 513 citations

The high-output nitric oxide pathway: role and regulation

1994 • 512 citations

Nitric oxide mediates neuronal death after focal cerebral ischemia in the mouse

1991 • 509 citations

An important role for the chemokine macrophage inflammatory protein-1 alpha in the pathogenesis of the T cell-mediated autoimmune disease, experimental autoimmune encephalomyelitis.

1995 • 487 citations

Isoforms of nitric oxide synthase

1995 • 482 citations

Inducible Nitric Oxide Synthase Gene Expression in Brain following Cerebral Ischemia

1995 • 479 citations

Nitric Oxide Modulates the Expression of Monocyte Chemoattractant Protein 1 in Cultured Human Endothelial Cells

1995 • 475 citations

Activation of the inducible form of nitric oxide synthase in the brains of patients with multiple sclerosis.

1995 • 464 citations

Immunologic NO Synthase: Elevation in Severe AIDS Dementia and Induction by HIV-1 gp41

1996 • 422 citations

Aminoguanidine, an inhibitor of inducible nitric oxide synthase, ameliorates experimental autoimmune encephalomyelitis in SJL mice.

1994 • 389 citations

Inhibition of inducible nitric oxide synthase ameliorates cerebral ischemic damage

1995 • 378 citations

Fibrillar β-Amyloid Induces Microglial Phagocytosis, Expression of Inducible Nitric Oxide Synthase, and Loss of a Select Population of Neurons in the Rat CNSIn Vivo

1998 • 353 citations

Prevention of experimental allergic encephalomyelitis by targeting nitric oxide and peroxynitrite: Implications for the treatment of multiple sclerosis

1997 • 337 citations

Inducible Nitric Oxide Synthase Gene Expression in Vascular Cells After Transient Focal Cerebral Ischemia

1996 • 331 citations

Expression of the inducible form of nitric oxide synthase by reactive astrocytes after transient global ischemia

1994 • 327 citations

Nitric oxide in excitable tissues: physiological roles and disease.

1997 • 312 citations

NO, nitrosonium ions, nitroxide ions, nitrosothiols and iron-nitrosyls in biology: a chemist's perspective

1995 • 301 citations

Fluid Flow Inhibits Endothelial Adhesiveness

1996 • 300 citations

Inducible nitric oxide synthase‐deficient mice have enhanced leukocyte–endothelium interactions in endotoxemia

1997 • 298 citations

Reactions between Nitric Oxide, Superoxide, and Peroxynitrite: Footprints of Peroxynitrite in Vivo

1995 • 295 citations

Heat Shock Protein 70 Suppresses Astroglial-inducible Nitric-oxide Synthase Expression by Decreasing NFκB Activation

1996 • 294 citations

Inducible nitric oxide synthase gene expression in the brain during systemic inflammation

1996 • 287 citations

Inducible nitric oxide synthase in tangle-bearing neurons of patients with Alzheimer's disease.

1996 • 285 citations

Expression of monocyte chemoattractant protein-1 and macrophage inflammatory protein-1 after focal cerebral ischemia in the rat

1995 • 283 citations

Increased Expression of TGF-β1 in Brain Tissue After Ischemic Stroke in Humans

1996 • 275 citations

Nitric oxide production during focal cerebral ischemia in rats.

1993 • 272 citations

Interleukin-8 Released into the Cerebrospinal Fluid after Brain Injury is Associated with Blood–Brain Barrier Dysfunction and Nerve Growth Factor Production

1997 • 266 citations

Strain-Related Differences in Susceptibility to Transient Forebrain Ischemia in SV-129 and C57Black/6 Mice

1997 • 249 citations

Inhibition of Nitric Oxide Synthesis Increases Focal Ischemic Infarction in Rat

1992 • 239 citations

The neuroprotective effect of a nitric oxide inhibitor in a rat model of focal cerebral ischaemia

1992 • 237 citations

C57BL/6 strain is most susceptible to cerebral ischemia following bilateral common carotid occlusion among seven mouse strains: selective neuronal death in the murine transient forebrain ischemia

1997 • 235 citations

Experimental Autoimmune Encephalomyelitis Is Exacerbated in Mice Lacking theNOS2Gene

1998 • 226 citations

Nitric oxide synthases

1996 • 222 citations

Marked Induction of Calcium-Independent Nitric Oxide Synthase Activity after Focal Cerebral Ischemia

1995 • 220 citations

Expression of CSF-1, c-fms, and MCP-1 in the central nervous system of rats with experimental allergic encephalomyelitis.

1993 • 218 citations

Induction of Nitric Oxide Synthase mRNA Expression

1995 • 215 citations

Immunocytochemical Characterization of the Expression of Inducible and Constitutive Isoforms of Nitric Oxide Synthase in Demyelinating Multiple Sclerosis Lesions

1997 • 205 citations

Neuronal (type I) nitric oxide synthase regulates nuclear factorκB activity and immunologic (type II) nitric oxide synthase expression

1997 • 202 citations

Cloning and expression of inducible nitric oxide synthase from rat astrocytes

1994 • 200 citations

Local nitric oxide production in viral and autoimmune diseases of the central nervous system.

1995 • 185 citations

Aminoguanidine Ameliorates and <scp>l</scp> -Arginine Worsens Brain Damage From Intraluminal Middle Cerebral Artery Occlusion

1996 • 184 citations

Expression of the inducible isoform of nitric oxide synthase in the central nervous system of mice correlates with the severity of actively induced experimental allergic encephalomyelitis

1995 • 181 citations

Nitric oxide regulates nitric oxide synthase-2 gene expression by inhibiting NF-κB binding to DNA

1997 • 171 citations

C-X-C and C-C chemokines are expressed in the cerebrospinal fluid in bacterial meningitis and mediate chemotactic activity on peripheral blood-derived polymorphonuclear and mononuclear cells in vitro.

1997 • 157 citations

Extensive peroxynitrite activity during progressive stages of central nervous system inflammation

1997 • 157 citations

Human immunodeficiency virus 1 envelope proteins induce interleukin 1, tumor necrosis factor alpha, and nitric oxide in glial cultures derived from fetal, neonatal, and adult human brain.

1995 • 154 citations

Experimental allergic encephalomyelitis in the rat is inhibited by aminoguanidine, an inhibitor of nitric oxide synthase

1996 • 152 citations

Chemokines in immune-mediated inflammation of the central nervous system

1996 • 144 citations

Administration of nitric oxide synthase inhibitors in experimental autoimmune neuritis and experimental autoimmune encephalomyelitis

1995 • 144 citations

Blockade of nitric oxide formation by mitigates ischemic brain edema and subsequent cerebral infarction in rats

1992 • 142 citations

Astrocytes and microglia express inducible nitric oxide synthase in mice with experimental allergic encephalomyelitis

1997 • 137 citations

Synergistic Induction of Nitric Oxide by β-Amyloid and Cytokines in Astrocytes

1996 • 134 citations

Macrophage inflammatory protein-1α in the cerebrospinal fluid of patients with multiple sclerosis and other inflammatory neurological diseases

1995 • 133 citations

Transient Increase of Cytokine-Induced Neutrophil Chemoattractant, a Member of the Interleukin-8 Family, in Ischemic Brain Areas After Focal Ischemia in Rats

1995 • 132 citations

Activation of Astrocytes in the Spinal Cord of Mice Chronically Infected with a Neurotropic Coronavirus

1995 • 128 citations

Aggravation of experimental allergic encephalomyelitis (EAE) by administration of nitric oxide (NO) synthase inhibitors

1996 • 124 citations

Roles of nitric oxide in compression injury of rat spinal cord

1996 • 120 citations

Inhibition of nitric oxide synthesis does not reduce infarct volume in a rat model of focal cerebral ischaemia

1992 • 119 citations

Inhibition of nitric oxide synthase attenuates blood-brain barrier disruption during experimental meningitis

1996 • 117 citations

Alteration of NF-κB p50 DNA Binding Kinetics by S-Nitrosylation

1997 • 115 citations

The effect of nitric oxide synthase inhibition on infarct volume after reversible focal cerebral ischemia in conscious rats.

1993 • 112 citations

Disassociation between the in vitro and in vivo effects of nitric oxide on a neurotropic murine coronavirus

1997 • 105 citations

New therapeutic possibility of blocking cytokine-induced neutrophil chemoattractant on transient ischemic brain damage in rats

1997 • 104 citations

Beta-amyloid (25-35) peptide and IFN-gamma synergistically induce the production of the chemotactic cytokine MCP-1/JE in monocytes and microglial cells.

1996 • 103 citations

Nitric oxide via an inducible isoform of nitric oxide synthase is a possible factor to eliminate inflammatory cells from the central nervous system of mice with experimental allergic encephalomyelitis

1997 • 99 citations

Chemokine expression in rat stab wound brain injury

1996 • 96 citations

Cytokines and Murine Autoimmune Encephalomyelitis: Inhibition or Enhancement of Disease with Antibodies to Select Cytokines, or by Delivery of Exogenous Cytokines Using a Recombinant Vaccinia Virus System

1995 • 95 citations

Nitric Oxide Limits Transcriptional Induction of Nitric Oxide Synthase in CNS Glial Cells

1994 • 95 citations

Transforming growth factor-β1 exhibits delayed gene expression following focal cerebral ischemia

1995 • 93 citations

Indirect evidence for nitric oxide involvement in multiple sclerosis by characterization of circulating antibodies directed against conjugated S-nitrosocysteine

1995 • 93 citations

Nitric Oxide Regulates IL-8 Expression in Melanoma Cells at the Transcriptional Level

1995 • 90 citations

Inducible nitric oxide synthase gene expression and enzyme activity correlate with disease activity in murine experimental autoimmune encephalomyelitis

1996 • 87 citations

C57BL/6 strain in most susceptible to cerebral ischemia following bilateral common carotid occlusion among seven mouse strains : selective neuronal death in the murine transient forebrain ischemia

1999 • 77 citations

Low Dose L-NAME Reduces Infarct Volume in the Rat MCAO/Reperfusion Model

1993 • 76 citations

Induction of nitric oxide synthase activity in rodent brain following middle cerebral artery occlusion

1995 • 76 citations

Expression of Inflammatory Cytokines and Inducible Nitric Oxide Synthase in Brains of SIV-Infected Rhesus Monkeys: Applications to HIV-Induced Central Nervous System Disease

1996 • 72 citations

Interleukin-8 inhibits the induction of nitric oxide synthase in rat peritoneal neutrophils

1992 • 68 citations

Induction of macrophage inflammatory protein MIP-1α mRNA on glial cells after focal cerebral ischemia in the rat

1997 • 66 citations

Nitric oxide biochemistry

1997 • 65 citations

Characterization and Functional Analysis of the Human Inducible Nitric Oxide Synthase Gene Promoter

1996 • 65 citations

Expression of monocyte chemoattractant protein (MCP-1) and nitric oxide synthase-2 following cerebral trauma

1998 • 64 citations

Suppression of Astroglial Nitric Oxide Synthase Expression by Norepinephrine Results from Decreased NOS‐2 Promoter Activity

1998 • 61 citations

Beta-interferon and multiple sclerosis

1997 • 60 citations

■ REVIEW : Glial NO: Normal and Pathological Roles

1996 • 54 citations

Inhibition of Nitric Oxide Synthesis Enhances the Expression of Inducible Nitric Oxide Synthase mRNA and Protein in a Model of Chronic Liver Inflammation

1994 • 53 citations

Pretreatment of Astrocytes with Interferon‐α/β Impairs Interferon‐γ Induction of Nitric Oxide Synthase

1997 • 52 citations

Inducible nitric oxide synthase in Theiler's murine encephalomyelitis virus infection

1997 • 52 citations

Expression of Inducible Nitric Oxide Synthase in Cerebral Endothelial Cells Is Regulated by Cytokine‐Activated Astrocytes

1995 • 51 citations

Activated astrocytes induce nitric oxide synthase-2 in cerebral endothelium via tumor necrosis factor ?

1997 • 51 citations

Brain nitrite production during global ischemia and reperfusion: an in vivo microdialysis study

1996 • 49 citations

Duration of expression of inducible nitric oxide synthase in glial cells

1994 • 46 citations

NO synthase-II is transiently expressed in embryonic mouse olfactory receptor neurons

1997 • 44 citations

Tumor necrosis factor and nitric oxide production by retinal M�ller glial cells from rats exhibiting inherited retinal dystrophy

1997 • 43 citations

Transient expression of calcium-independent nitric oxide synthase in blood vessels during brain development.

1995 • 43 citations

Induction of cytokines, chemokines and adhesion molecule mRNA in a rat forebrain reperfusion model

1997 • 40 citations

NEURONAL (TYPE I) NITRIC OXIDE SYNTHASE REGULATES NUCLEAR FACTOR ϰ B ACTIVITY AND IMMUNOLOGIC (TYPE II) NITRIC OXIDE SYNTHASE EXPRESSION

1997 • 38 citations

Gender differences of inducible nitric oxide production in SJL/J mice with experimental autoimmune encephalomyelitis

1997 • 38 citations

Nitric oxide synthase Type II expression by different cell types in MHV-JHM encephalitis suggests distinct roles for nitric oxide in acute versus persistent virus infection

1997 • 36 citations

Cytokine‐ and Endotoxin‐Induced Nitric Oxide Synthase in Rat Astroglial Cultures: Differential Modulation by Angiotensin II

1997 • 35 citations

Monocyte Chemotactic Protein-1 Inhibits the Induction of Nitric Oxide Synthase in J774 Cells

1993 • 28 citations

Nitric Oxide Synthase Type II mRNA Stability Is Translation‐ and Transcription‐Dependent

1996 • 26 citations

Exacerbation of lymphocytic choriomeningitis in mice treated with the inducible nitric oxide synthase inhibitor aminoguanidine

1996 • 24 citations

Local injection of kainic acid causes widespread degeneration of NADPH-d neurons and induction of NADPH-d in neurons, endothelial cells and reactive astrocytes

1996 • 22 citations

Regulation of Astrocyte Nitric Oxide Synthase Type II Expression by ATP and Glutamate Involves Loss of Transcription Factor Binding to DNA

1997 • 20 citations

Role of Nitric Oxide in Brain Ischemia^a

1994 • 19 citations

In vivo expression of inducible nitric oxide synthase in supraventricular amoeboid microglial cells in neonatal BALB/c and athymic mice

1997 • 17 citations

Regulation of gene expression in the nervous system by reactive oxygen and nitrogen species

1997 • 13 citations

Effects of Trypsin and Certain Surface-Active Agents on Meningo-Pneumonitis Virus and on Normal Chorio-Allantoic Membrane Particulates

1956 • 10 citations

Local injection of kainic acid causes widespread degeneration of NADPH-d neurons and induction of NADPH-d in neurons, endothelial cells and reactive astrocytes

1996 • 6 citations