Expression of the inducible isoform of nitric oxide synthase in the central nervous system of mice correlates with the severity of actively induced experimental allergic encephalomyelitis

Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.

1988 • 2,865 citations

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

Role of nitric oxide synthesis in macrophage antimicrobial activity

1991 • 1,547 citations

Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro

1988 • 1,371 citations

Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide.

1993 • 782 citations

Potential antiinflammatory effects of interleukin 4: suppression of human monocyte tumor necrosis factor alpha, interleukin 1, and prostaglandin E2.

1989 • 741 citations

Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain.

1992 • 726 citations

IL-10 inhibits parasite killing and nitrogen oxide production by IFN-gamma-activated macrophages.

1992 • 709 citations

An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis.

1990 • 692 citations

Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor beta.

1993 • 658 citations

Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery.

1992 • 627 citations

Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains

1994 • 570 citations

Interferon‐γ and tumor necrosis factor induce the L‐arginine‐dependent cytotoxic effector mechanism in murine macrophages^*

1988 • 511 citations

Macrophage deactivating factor and transforming growth factors-beta 1 -beta 2 and -beta 3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-gamma.

1990 • 507 citations

Induction of Nitric Oxide Synthase in Glial Cells

1992 • 501 citations

Induction of calcium-independent nitric oxide synthase activity in primary rat glial cultures.

1992 • 484 citations

In vivo expression of inducible nitric oxide synthase in experimentally induced neurologic diseases.

1993 • 484 citations

Cytokine cytotoxicity against oligodendrocytes. Apoptosis induced by lymphotoxin.

1991 • 455 citations

Anti—tumor necrosis factor therapy abrogates autoimmune demyelination

1991 • 434 citations

Enhancement of experimental allergic encephalomyelitis in mice by antibodies against IFN-gamma.

1988 • 432 citations

IL-10 synergizes with IL-4 and transforming growth factor-beta to inhibit macrophage cytotoxic activity.

1992 • 422 citations

TNF-alpha expression by resident microglia and infiltrating leukocytes in the central nervous system of mice with experimental allergic encephalomyelitis. Regulation by Th1 cytokines.

1995 • 401 citations

Aminoguanidine, an inhibitor of inducible nitric oxide synthase, ameliorates experimental autoimmune encephalomyelitis in SJL mice.

1994 • 389 citations

Prevention and treatment of chronic relapsing experimental allergic encephalomyelitis by transforming growth factor-beta 1.

1991 • 385 citations

Interleukin‐10 prevents experimental allergic encephalomyelitis in rats

1994 • 377 citations

Induction of nitric oxide synthase activity in human astrocytes by interleukin-1β and interferon-γ

1993 • 355 citations

Inflammatory leukocytes and cytokines in the peptide-induced disease of experimental allergic encephalomyelitis in SJL and B10.PL mice.

1992 • 299 citations

Monoclonal antibodies to murine gamma-interferon which differentially modulate macrophage activation and antiviral activity.

1985 • 286 citations

Lymphotoxin and tumor necrosis factor-alpha production by myelin basic protein-specific T cell clones correlates with encephalitogenicity

1990 • 285 citations

Ubiquitous MyoD transcription at the midblastula transition precedes induction-dependent MyoD expression in presumptive mesoderm of X. laevis

1991 • 248 citations

IL-4 inhibits H2O2 production and antileishmanial capacity of human cultured monocytes mediated by IFN-gamma.

1989 • 228 citations

Neuroprotective role of IL-4 against activated microglia.

1993 • 214 citations

Experimental autoimmune encephalomyelitis is exacerbated by IL-1 alpha and suppressed by soluble IL-1 receptor.

1991 • 183 citations

Studies on the mechanisms by which transforming growth factor-beta (TGF-beta) protects against allergic encephalomyelitis. Antagonism between TGF-beta and tumor necrosis factor.

1993 • 170 citations

Effect of anti-interferon-γ and anti-interleukin-2 monoclonal antibody treatment on the development of actively and passively induced experimental allergic encephalomyelitis in the SJL/J mouse

1992 • 156 citations

Nitric oxide localized to spinal cords of mice with experimental allergic encephalomyelitis: an electron paramagnetic resonance study.

1993 • 153 citations

Cytokines in neuroinflammatory disease: role of myelin autoreactive T cell production of interferon-gamma

1992 • 146 citations

Elevated secretion of reactive nitrogen and oxygen intermediates by inflammatory leukocytes in hyperacute experimental autoimmune encephalomyelitis: enhancement by the soluble products of encephalitogenic T cells.

1992 • 136 citations

Cytokines Regulate L‐Arginine‐Dependent Cyclic GMP Production in Rat Glial Cells

1993 • 124 citations

Demonstration of interleukin-1β in Lewis rat brain during experimental allergic encephalomyelitis by immunocytochemistry at the light and ultrastructural level

1993 • 119 citations

T cell immunity and interferon-γ secretion during experimental allergic encephalomyelitis in Lewis rats

1991 • 107 citations

Cytokines in the central nervous system of mice during chronic relapsing experimental allergic encephalomyelitis

1991 • 99 citations

Nitric oxide-mediated neuronal injury in multiple sclerosis

1992 • 90 citations

Cytokine production by cells in cerebrospinal fluid during experimental allergic encephalomyelitis in SJL/J mice

1994 • 84 citations

Antigen-specific inhibition of immune interferon production by suppressor cells of autoimmune encephalomyelitis.

1988 • 83 citations

Immunohistochemical localization of an inducible form of nitric oxide synthase in various organs of rats treated with Propionibacterium acnes and lipopolysaccharide

1993 • 80 citations

Transforming growth factor-β1 inhibits tumor necrosis factor-α/lymphotoxin production and adoptive transfer of disease by effector cells of autoimmune encephalomyelitis

1994 • 69 citations

Polyclonal antibody against an inducible form of nitric oxide synthase purified from the liver of rats treated with Propionibacterium acnes and lipopolysaccharide

1992 • 58 citations

Perforin and Tumor Necrosis Factor α in the Pathogenesis of Experimental Allergic Encephalomyelitis: Comparison of Autoantigen Induced and Transferred Disease in Lewis Rats

1993 • 18 citations