Blockade of nitric oxide formation by mitigates ischemic brain edema and subsequent cerebral infarction in rats

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

1990 • 3,304 citations

Glutamate, nitric oxide and cell-cell signalling in the nervous system

1991 • 2,406 citations

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

1991 • 2,371 citations

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

1991 • 2,173 citations

Neuronal NADPH diaphorase is a nitric oxide synthase.

1991 • 1,917 citations

Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues.

1991 • 1,872 citations

Nitric oxide, a novel neuronal messenger

1992 • 1,864 citations

Molecular cloning and characterization of the rat NMDA receptor

1991 • 1,780 citations

Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage

1988 • 1,745 citations

Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid

1986 • 1,283 citations

Calcium Fluxes, Calcium Antagonists, and Calcium-Related Pathology in Brain Ischemia, Hypoglycemia, and Spreading Depression: A Unifying Hypothesis

1989 • 1,237 citations

Tests of the roles of two diffusible substances in long-term potentiation: evidence for nitric oxide as a possible early retrograde messenger.

1991 • 1,016 citations

Anatomical organization of excitatory amino acid receptors and their pathways

1987 • 877 citations

Isoforms of nitric oxide synthase Characterization and purification from different cell types

1991 • 827 citations

Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide

1992 • 702 citations

Pharmacology of Cerebral Ischemia

1989 • 675 citations

Ca2+/calmodulin-dependent formation of hydrogen peroxide by brain nitric oxide synthase

1992 • 534 citations

Nitric oxide mediates neuronal death after focal cerebral ischemia in the mouse

1991 • 509 citations

Purification of a Ca²⁺/calmodulin‐dependent nitric oxide synthase from porcine cerebellum

1990 • 433 citations

Neurons that say NO

1992 • 421 citations

Nitric oxide synthase: Irreversible inhibition by L-N -Nitroarginine in brain and

1991 • 368 citations

Vulnerability of cultured cortical neurons to damage by excitotoxins: differential susceptibility of neurons containing NADPH-diaphorase

1988 • 309 citations

Ischemic brain edema following occlusion of the middle cerebral artery in the rat. I: The time courses of the brain water, sodium and potassium contents and blood-brain barrier permeability to 125I-albumin.

1985 • 300 citations

Neurons Containing NADPH-Diaphorase Are Selectively Resistant to Quinolinate Toxicity

1986 • 292 citations

Neurochemical Correlates to Selective Neuronal Vulnerability

1985 • 252 citations

Evidence for an Astrocyte‐Derived Vasorelaxing Factor with Properties Similar to Nitric Oxide

1990 • 196 citations

Nitric oxide inhibitors attenuate excitotoxicity in rat hippocampal slices

1992 • 174 citations

Chronic Dexamethasone Pretreatment Aggravates Ischemic Neuronal Necrosis

1986 • 172 citations

Protective effects of human recombinant superoxide dismutase on transient ischemic injury of CA1 neurons in gerbils.

1992 • 96 citations

Purification of nitric oxide synthase from bovine brain: Immunological characterization and tissue distribution

1992 • 86 citations

Post-Ischemic Resuscitation of the Brain: Selective Vulnerability Versus Global Resistance

1985 • 79 citations

Protective effects of human recombinant superoxide dismutase on transient ischemic injury of CA1 neurons in gerbils.

1992 • 48 citations

Amelioration of ischaemic cerebral oedema by a free radical scavenger, AVS: 1,2-bis(nicotinamido)-propane. An experimental study using a regional ischaemia model in cats

1984 • 44 citations

The role of free radicals and eicosanoids in the pathogenetic mechanism underlying ischemic brain edema

1989 • 33 citations

Effect of enhanced capillary activity on the blood-brain barrier during focal cerebral ischemia in cats.

1989 • 25 citations