Fluid Flow Inhibits Endothelial Adhesiveness

Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines.

1995 • 1,762 citations

Endothelial Expression of a Mononuclear Leukocyte Adhesion Molecule During Atherogenesis

1991 • 1,703 citations

Atherosclerosis: Basic Mechanisms

1995 • 1,697 citations

Flow Effects on Prostacyclin Production by Cultured Human Endothelial Cells

1985 • 1,237 citations

Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB

1993 • 1,129 citations

Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells.

1993 • 1,079 citations

Hemodynamics and atherosclerosis. Insights and perspectives gained from studies of human arteries.

1988 • 1,024 citations

Crucial role of endothelium in the vasodilator response to increased flow in vivo.

1986 • 991 citations

Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression.

1994 • 941 citations

Effects of intensive multiple risk factor reduction on coronary atherosclerosis and clinical cardiac events in men and women with coronary artery disease. The Stanford Coronary Risk Intervention Project (SCRIP).

1994 • 896 citations

Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene

1993 • 881 citations

Flow patterns and spatial distribution of atherosclerotic lesions in human coronary arteries.

1990 • 844 citations

Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase.

1992 • 748 citations

Nitric oxide, an endothelial cell relaxation factor, inhibits neutrophil superoxide anion production via a direct action on the NADPH oxidase.

1992 • 712 citations

Induction and Stabilization of IκBα by Nitric Oxide Mediates Inhibition of NF-κB

1995 • 707 citations

Antiatherogenic effects of L-arginine in the hypercholesterolemic rabbit.

1992 • 697 citations

An atherogenic diet rapidly induces VCAM-1, a cytokine-regulatable mononuclear leukocyte adhesion molecule, in rabbit aortic endothelium.

1993 • 680 citations

Pathological implications of nitric oxide, superoxide and peroxynitrite formation

1993 • 679 citations

NF-kappa B activation by ultraviolet light not dependent on a nuclear signal

1993 • 646 citations

Platelet-derived growth factor B chain promoter contains a cis-acting fluid shear-stress-responsive element.

1993 • 638 citations

Flow activates an endothelial potassium channel to release an endogenous nitrovasodilator.

1991 • 529 citations

Chronic inhibition of nitric oxide production accelerates neointima formation and impairs endothelial function in hypercholesterolemic rabbits.

1994 • 501 citations

Nitric Oxide Modulates the Expression of Monocyte Chemoattractant Protein 1 in Cultured Human Endothelial Cells

1995 • 475 citations

Cellular Pathology As Based upon Physiological and Pathological Histology.

1972 • 460 citations

Inhibition of low‐density lipoprotein oxidation by nitric oxide Potential role in atherogenesis

1993 • 411 citations

Shear stress regulates endothelin-1 release via protein kinase C and cGMP in cultured endothelial cells

1993 • 386 citations

Expression of ICAM-1 and VCAM-1 and Monocyte Adherence in Arteries Exposed to Altered Shear Stress

1995 • 374 citations

Inhibition of nitric oxide production. Mechanisms of vascular albumin leakage.

1993 • 352 citations

Antioxidants inhibit monocyte adhesion by suppressing nuclear factor-kappa B mobilization and induction of vascular cell adhesion molecule-1 in endothelial cells stimulated to generate radicals.

1994 • 349 citations

Intracellular oxidative stress induced by nitric oxide synthesis inhibition increases endothelial cell adhesion to neutrophils.

1994 • 334 citations

Nitric oxide and prostacyclin. Divergence of inhibitory effects on monocyte chemotaxis and adhesion to endothelium in vitro.

1991 • 331 citations

Enhanced endothelial adhesiveness in hypercholesterolemia is attenuated by L-arginine.

1994 • 330 citations

Shear stress elevates endothelial cGMP. Role of a potassium channel and G protein coupling.

1993 • 260 citations

Flow stimulates endothelial cells to release a nitrovasodilator that is potentiated by reduced thiol

1990 • 260 citations

Long-term inhibition of NO synthesis promotes atherosclerosis in the hypercholesterolemic rabbit thoracic aorta. PGH2 does not contribute to impaired endothelium-dependent relaxation.

1994 • 255 citations

Shear Stress Induces ATP-Independent Transient Nitric Oxide Release From Vascular Endothelial Cells, Measured Directly With a Porphyrinic Microsensor

1995 • 209 citations

Topography of atherosclerosis in the coronary arteries.

1968 • 202 citations

Exposure to Shear Stress Alters Endothelial Adhesiveness

1995 • 181 citations

Apparatus for subjecting living cells to fluid shear stress

1982 • 174 citations

Loss of flow-mediated endothelium-dependent dilation occurs early in the development of atherosclerosis.

1991 • 165 citations

Decreased basal nitric oxide release in hypercholesterolemia increases neutrophil adherence to rabbit coronary artery endothelium.

1993 • 155 citations

Dietary arginine prevents atherogenesis in the coronary artery of the hypercholesterolemic rabbit

1994 • 123 citations

A protective role for nitric oxide in the oxidative modification of low density lipoproteins by mouse macrophages

1992 • 117 citations

Monocyte adhesion and changes in endothelial cell number, morphology, and F-actin distribution elicited by low shear stress in vivo.

1993 • 111 citations

Quantification in vivo of increased LDL content and rate of LDL degradation in normal rabbit aorta occurring at sites susceptible to early atherosclerotic lesions.

1988 • 95 citations

The Effect of Flow on the Expression of Vascular Adhesion Molecule-1 by Cultured Mouse Endothelial Cells

1993 • 92 citations

Topographic study of sudanophilic lesions in cholesterol-fed minipigs by image analysis.

1985 • 90 citations

Superoxide anion production by rabbit thoracic aorta: effect of endothelium-derived nitric oxide

1993 • 77 citations

Superoxide-dependent stimulation of leukocyte adhesion by oxidatively modified LDL in vivo.

1992 • 75 citations

Quantitative Investigation of Sudanophilic Lesions around the Aortic Ostia of Human Fetuses, Newborn and Children

1980 • 58 citations

Mediators of endotoxin-induced leukocyte adhesion in mesenteric postcapillary venules.

1994 • 38 citations

Cellular pathology as based upon physiological and pathological histology : twenty lectures delivered in the Pathological Institute of Berlin

1860 • 30 citations

Effect of substituted arginine compounds on superoxide production in the rabbit aorta.

1991 • 24 citations

The domestic goat: A useful model to determine effects of diet and exercise on cholesterol accumulation in the body

1990 • 11 citations

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