Nitric oxide synthase Type II expression by different cell types in MHV-JHM encephalitis suggests distinct roles for nitric oxide in acute versus persistent virus infection

Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase

1995 • 1,454 citations

Altered immune responses in mice lacking inducible nitric oxide synthase

1995 • 1,296 citations

Activated microglia mediate neuronal cell injury via a nitric oxide mechanism.

1992 • 1,121 citations

Inhibition of Viral Replication by Interferon-γ-Induced Nitric Oxide Synthase

1993 • 825 citations

Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide.

1993 • 782 citations

Inflammatory cytokines within the central nervous system: sources, function, and mechanism of action

1992 • 614 citations

Microbiostatic effect of murine-activated macrophages for Toxoplasma gondii. Role for synthesis of inorganic nitrogen oxides from L-arginine.

1990 • 573 citations

Induction of Nitric Oxide Synthase in Glial Cells

1992 • 501 citations

In vivo expression of inducible nitric oxide synthase in experimentally induced neurologic diseases.

1993 • 484 citations

TNF-alpha expression by resident microglia and infiltrating leukocytes in the central nervous system of mice with experimental allergic encephalomyelitis. Regulation by Th1 cytokines.

1995 • 401 citations

Aminoguanidine, an inhibitor of inducible nitric oxide synthase, ameliorates experimental autoimmune encephalomyelitis in SJL mice.

1994 • 389 citations

A MURINE VIRUS (JHM) CAUSING DISSEMINATED ENCEPHALOMYELITIS WITH EXTENSIVE DESTRUCTION OF MYELIN

1949 • 345 citations

Pathogenesis of Demyelination Induced by a Mouse Hepatitis

1973 • 340 citations

Cloning of Inducible Nitric Oxide Synthase in Rat Vascular Smooth Muscle Cells

1993 • 319 citations

Selective potentiation of NMDA-induced neuronal injury following induction of astrocytic iNOS

1994 • 301 citations

The killing of Leishmania major by human macrophages is mediated by nitric oxide induced after ligation of the Fc epsilon RII/CD23 surface antigen.

1995 • 270 citations

Mechanism of demyelination in JHM virus encephalomyelitis

1973 • 253 citations

Expression of inducible nitric oxide synthase causes delayed neurotoxicity in primary mixed neuronal-glial cortical cultures

1994 • 251 citations

Production of B cell stimulatory factor-2 and interferon gamma in the central nervous system during viral meningitis and encephalitis. Evaluation in a murine model infection and in patients.

1988 • 246 citations

A MURINE VIRUS (JHM) CAUSING DISSEMINATED ENCEPHALOMYELITIS WITH EXTENSIVE DESTRUCTION OF MYELIN

1949 • 230 citations

Inducible nitric oxide synthase activity of cloned murine microglial cells

1993 • 218 citations

Neuroprotective role of IL-4 against activated microglia.

1993 • 214 citations

Inflammatory mediators in demyelinating disorders of the CNS and PNS

1992 • 213 citations

Experimental demyelination produced by the A59 strain of mouse hepatitis virus

1984 • 192 citations

Effective clearance of mouse hepatitis virus from the central nervous system requires both CD4+ and CD8+ T cells

1990 • 189 citations

Analysis of cytokine gene expression during fetal thymic ontogeny using the polymerase chain reaction.

1991 • 175 citations

Inhibition of vesicular stomatitis virus infection by nitric oxide

1995 • 161 citations

Chronic central nervous system demyelination in mice after JHM virus infection

1981 • 158 citations

Expression of inducible nitric oxide synthase by neurones following exposure to endotoxin and cytokine

1994 • 157 citations

Cytokine induction during T-cell-mediated clearance of mouse hepatitis virus from neurons in vivo

1994 • 152 citations

Vesicular stomatitis virus infection of the central nervous system activates both innate and acquired immunity

1995 • 150 citations

Tumor necrosis factor α and transforming growth factor β upregulate astrocyte expression of monocyte chemoattractant protein-1

1995 • 129 citations

Activation of Astrocytes in the Spinal Cord of Mice Chronically Infected with a Neurotropic Coronavirus

1995 • 128 citations

Corona virus induced subacute demyelinating encephalomyelitis in rats: A morphological analysis

1978 • 126 citations

The cellular and molecular pathogenesis of coronaviruses.

1993 • 124 citations

Demonstration of interleukin-1β in Lewis rat brain during experimental allergic encephalomyelitis by immunocytochemistry at the light and ultrastructural level

1993 • 119 citations

In Vivo and In Vitro Models of Demyelinating Diseases

1980 • 117 citations

Appearance of inducible nitric oxide synthase in the rat central nervous system after rabies virus infection and during experimental allergic encephalomyelitis but not after peripheral administration of endotoxin

1995 • 112 citations

Late onset, symptomatic, demyelinating encephalomyelitis in mice infected with MHV-JHM in the presence of maternal antibody

1987 • 104 citations

T-cell-mediated clearance of mouse hepatitis virus strain JHM from the central nervous system

1989 • 101 citations

Severity of neurological signs and degree of inflammatory lesions in the brains of rats with Borna disease correlate with the induction of nitric oxide synthase

1993 • 99 citations

IFN and virus-inducible expression of an immediate early gene, crg-2/IP-10, and a delayed gene, I-A alpha in astrocytes and microglia.

1994 • 98 citations

Nitric oxide-mediated neuronal injury in multiple sclerosis

1992 • 90 citations

Sequential infection of glial cells by the murine hepatitis virus JHM strain (MHV-4) leads to a characteristic distribution of demyelination.

1992 • 84 citations

Production of mice from a lethal coronavirus infection in the central nervous system by adoptive transfer of virus-specific T cell clones

1991 • 77 citations

Nucleocapsid or spike protein-specific CD4+ T lymphocytes protect against coronavirus-induced encephalomyelitis in the absence of CD8+ T cells.

1991 • 76 citations

Differential Induction of Cytokines by Primary and Persistent Measles Virus Infections in Human Glial Cells

1993 • 71 citations

Expression of the inducible nitric oxide synthase. Correlation with neuropathology and clinical features in mice with lymphocytic choriomeningitis.

1994 • 67 citations

Expression of inducible nitric oxide synthase in cytomegalovirus-infected glial cells of retinas from AIDS patients

1994 • 66 citations

The astrocyte is a target cell in mice persistently infected with mouse hepatitis virus, strain JHM

1987 • 55 citations

Expression of Inducible Nitric Oxide Synthase in Cerebral Endothelial Cells Is Regulated by Cytokine‐Activated Astrocytes

1995 • 51 citations

Spread of a neurotropic coronavirus to spinal cord white matter via neurons and astrocytes

1995 • 48 citations

Experimental Neuropathology of Chronic Demyelination Induced by a JHM Virus Variant (DS)

1987 • 28 citations

Regional localization of virus in the central nervous system of mice persistently infected with murine coronavirus JHM

1988 • 28 citations

Expression of nitric oxide synthase type II in the spinal cord under conditions producing thermal hyperalgesia

1996 • 26 citations

Are CNS Lesions Produced by Free Radicals?

1994 • 2 citations