A major human immunodeficiency virus type 1-initiated killing pathway distinct from apoptosis

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

1995 • 4,310 citations

The Fas Death Factor

1995 • 4,070 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Viral dynamics in human immunodeficiency virus type 1 infection

1995 • 3,277 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

Programmed Cell Death in Animal Development

1997 • 2,690 citations

Social controls on cell survival and cell death

1992 • 2,641 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

1996 • 2,306 citations

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis

1989 • 1,739 citations

Developmental cell death: morphological diversity and multiple mechanisms

1990 • 1,695 citations

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

1995 • 1,662 citations

Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis

1984 • 1,586 citations

The Human Immunodeficiency Virus: Infectivity and Mechanisms of Pathogenesis

1988 • 1,496 citations

A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor.

1989 • 1,436 citations

Molecular thanatopsis: a discourse on the BCL2 family and cell death

1996 • 1,412 citations

A TH1→TH2 switch is a critical step in the etiology of HIV infection

1993 • 1,403 citations

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1991 • 1,223 citations

Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around Jh on chromosome 14 and near a transcriptional unit on 18

1985 • 1,188 citations

C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2

1994 • 1,145 citations

Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma.

1986 • 1,118 citations

Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120

1995 • 983 citations

Fas ligand mediates activation-induced cell death in human T lymphocytes.

1995 • 949 citations

Programmed Death of T Cells in HIV-1 Infection

1992 • 932 citations

BAX-induced cell death may not require interleukin 1β-converting enzyme-like proteases

1996 • 911 citations

Activation-induced death by apoptosis in CD4+ T cells from human immunodeficiency virus-infected asymptomatic individuals.

1992 • 907 citations

Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity

1995 • 885 citations

Role of the HTLV-III/LAV envelope in syncytium formation and cytopathicity

1986 • 804 citations

Multifactorial Nature of Human Immunodeficiency Virus Disease: Implications for Therapy

1993 • 803 citations

Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis.

1995 • 791 citations

Activation of cdc2 protein kinase during mitosis in human cells: Cell cycle-dependent phosphorylation and subunit rearrangement

1988 • 786 citations

Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis.

1992 • 689 citations

Evidence for a role of virulent human immunodeficiency virus (HIV) variants in the pathogenesis of acquired immunodeficiency syndrome: studies on sequential HIV isolates

1989 • 662 citations

Differential syncytium-inducing capacity of human immunodeficiency virus isolates: frequent detection of syncytium-inducing isolates in patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex

1988 • 621 citations

Induction of Apoptosis in Uninfected Lymphocytes by HIV-1 Tat Protein

1995 • 581 citations

Programmed Cell Death in the Immune System

1991 • 575 citations

Cell dysfunction and depletion in AIDS: the programmed cell death hypothesis

1991 • 548 citations

The human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2 + M phase of the cell cycle

1995 • 518 citations

Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15.

1993 • 475 citations

Increased viral burden and cytopathicity correlate temporally with CD4+ T-lymphocyte decline and clinical progression in human immunodeficiency virus type 1-infected individuals

1993 • 464 citations

Preferential infection of CD4+ memory T cells by human immunodeficiency virus type 1: evidence for a role in the selective T-cell functional defects observed in infected individuals.

1990 • 443 citations

ICE Family Proteases: Mediators of All Apoptotic Cell Death?

1996 • 440 citations

Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals.

1995 • 438 citations

Apoptosis as a mechanism of cell death in cultured T lymphoblasts acutely infected with HIV-1.

1991 • 432 citations

Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B

1995 • 382 citations

The 19-Kilodalton Adenovirus E1B Transforming Protein Inhibits Programmed Cell Death and Prevents Cytolysis by Tumor Necrosis Factor α

1992 • 354 citations

Human immunodeficiency virus type 1 Vpr induces apoptosis following cell cycle arrest

1997 • 348 citations

Selective Depletion in HIV Infection of T Cells that Bear Specific T Cell Receptor V _β Sequences

1991 • 322 citations

Upregulation of Fas ligand expression by human immunodeficiency virus in human macrophages mediates apoptosis of uninfected T lymphocytes

1996 • 316 citations

T helper type 1/T helper type 2 cytokines and T cell death: preventive effect of interleukin 12 on activation-induced and CD95 (FAS/APO-1)-mediated apoptosis of CD4+ T cells from human immunodeficiency virus-infected persons.

1995 • 283 citations

Human immunodeficiency virus type 1 variants with increased replicative capacity develop during the asymptomatic stage before disease progression

1994 • 253 citations

The Immunopathogenesis of HIV Infection

1989 • 233 citations

D4-GDI, a Substrate of CPP32, Is Proteolyzed during Fas-induced Apoptosis

1996 • 216 citations

Stress-resistance conferred by high level of bcl-2 alpha protein in human B lymphoblastoid cell.

1989 • 216 citations

Membrane Expression of HIV Envelope Glycoproteins Triggers Apoptosis in CD4 Cells

1993 • 210 citations

Apoptosis mediated by HIV protease is preceded by cleavage of Bcl-2.

1996 • 195 citations

Fas-mediated apoptosis of CD4+ and CD8+ T cells from human immunodeficiency virus-infected persons: differential in vitro preventive effect of cytokines and protease antagonists

1996 • 189 citations

gp120 of HIV-1 induces apoptosis in rat cortical cell cultures: prevention by memantine

1992 • 174 citations

Inhibition of CD4+ T cell function by the HIV envelope protein, gp120.

1988 • 160 citations

Programmed death of T cells in human immunodeficiency virus infection. No correlation with progression to disease.

1994 • 152 citations

Programmed cell death by bcl-2-dependent and independent mechanisms in B lymphoma cells.

1993 • 147 citations

Dual role of HIV Tat in regulation of apoptosis in T cells.

1997 • 142 citations

Molecular determinants of acute single-cell lysis by human immunodeficiency virus type 1

1996 • 140 citations

Cell death in embryogenesis

1981 • 138 citations

Synergism Between HIV gp120 and gp120-Specific Antibody in Blocking Human T Cell Activation

1989 • 135 citations

Inhibition of activation-induced programmed cell death and restoration of defective immune responses of HIV+ donors by cysteine protease inhibitors.

1994 • 131 citations

The gene family

1995 • 130 citations

Defective expression of hematopoietic cell protein tyrosine phosphatase (HCP) in lymphoid cells blocks Fas-mediated apoptosis

1995 • 123 citations

The E1b oncogene of adenovirus confers cellular resistance to cytotoxicity of tumor necrosis factor and monoclonal anti-Fas antibody

1991 • 119 citations

The cell cycle block and lysis of an activated T cell hybridoma are distinct processes with different Ca2+ requirements and sensitivity to cyclosporine A.

1989 • 110 citations

The apoptosis endonuclease and its regulation.

1992 • 108 citations

Human immunodeficiency virus gp120 and derived peptides activate protein tyrosine kinase p56Ick in human CD4 T lymphocytes

1993 • 104 citations

Involvement of apoptosis antigen Fas in clonal deletion of human thymocytes

1994 • 97 citations

Inhibition of apoptosis in human immunodeficiency virus-infected cells enhances virus production and facilitates persistent infection

1995 • 93 citations

Pleiotropic effects of immobilized versus soluble recombinant HIV-1 Tat protein on CD3-mediated activation, induction of apoptosis, and HIV-1 long terminal repeat transactivation in purified CD4+ T lymphocytes.

1996 • 86 citations

HIV Type 1 Tat Protein Induces Apoptosis and Death in Jurkat Cells

1995 • 82 citations

gp120 ligation of CD4 induces p56lck activation and TCR desensitization independent of TCR tyrosine phosphorylation.

1994 • 70 citations

Apoptosis: A sticky business

1995 • 57 citations

Membrane-expressed HIV envelope glycoprotein heterodimer is a powerful inducer of cell death in uninfected CD4+ target cells

1995 • 45 citations

Human immunodeficiency virus 1 envelope-initiated G2-phase programmed cell death.

1995 • 44 citations

bc1-2 expression facilitates human immunodeficiency virus type-1 mediated cytopathic effects during acute spreading infections

1996 • 39 citations

Induction of Developmentally Programmed Cell Death and Activation of HIV by Sodium Butyrate

1994 • 25 citations

Effects of Human Immunodeficiency Virus Type 1 Infection on Programmed Cell Death in the Presence or Absence of Bcl-2

1996 • 17 citations

Normal T cell receptor-mediated signaling in T cell lines stably expressing HIV-1 envelope glycoproteins.

1993 • 10 citations