Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

1995 • 4,310 citations

Principles of CDK regulation

1995 • 3,267 citations

Production of high-titer helper-free retroviruses by transient transfection.

1993 • 2,280 citations

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1990 • 2,129 citations

Vpr Is Required for Efficient Replication of Human Immunodeficiency Virus Type-1 in Mononuclear Phagocytes

1995 • 1,252 citations

Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120

1995 • 983 citations

Activation-induced death by apoptosis in CD4+ T cells from human immunodeficiency virus-infected asymptomatic individuals.

1992 • 907 citations

The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells.

1994 • 845 citations

Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15.

1992 • 638 citations

Premature p34 ^cdc2 Activation Required for Apoptosis

1994 • 568 citations

The human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2 + M phase of the cell cycle

1995 • 518 citations

Differential phosphorylation of vertebrate p34cdc2 kinase at the G1/S and G2/M transitions of the cell cycle: identification of major phosphorylation sites.

1991 • 439 citations

Cdc2 regulatory factors

1994 • 414 citations

The human immunodeficiency virus type 1 vpr gene prevents cell proliferation during chronic infection

1995 • 411 citations

Incorporation of Vpr into human immunodeficiency virus type 1 virions: requirement for the p6 region of gag and mutational analysis

1993 • 368 citations

The 19-Kilodalton Adenovirus E1B Transforming Protein Inhibits Programmed Cell Death and Prevents Cytolysis by Tumor Necrosis Factor α

1992 • 354 citations

Activation of cyclin A-dependent protein kinases during apoptosis.

1994 • 352 citations

Human cyclin-dependent kinase 2 is activated during the S and G2 phases of the cell cycle and associates with cyclin A.

1992 • 331 citations

Viruses and apoptosis

1995 • 324 citations

Mutations of p34cdc2 phosphorylation sites induce premature mitotic events in HeLa cells: evidence for a double block to p34cdc2 kinase activation in vertebrates.

1991 • 318 citations

Pseudotyping with human T-cell leukemia virus type I broadens the human immunodeficiency virus host range

1991 • 274 citations

Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr

1995 • 260 citations

Identification of HIV-1 vpr product and function.

1990 • 251 citations

Progression to AIDS in the absence of a gene for vpr or vpx

1995 • 243 citations

Distinct Effects in Primary Macrophages and Lymphocytes of the Human Immunodeficiency Virus Type 1 Accessory Genes vpr, vpu, and nef: Mutational Analysis of a Primary HIV-1 Isolate

1994 • 237 citations

A gentle fixation and permeabilization method for combined cell surface and intracellular staining with improved precision in DNA quantification

1991 • 235 citations

Importance of vpr for infection of rhesus monkeys with simian immunodeficiency virus

1993 • 220 citations

Induction of cell differentiation by human immunodeficiency virus 1 vpr

1993 • 214 citations

Mutational analysis of the human immunodeficiency virus vpr open reading frame

1989 • 183 citations

The human B cell-associated antigen CD24 is a single chain sialoglycoprotein.

1986 • 116 citations

Viral protein R of human immunodeficiency virus types 1 and 2 is dispensable for replication and cytopathogenicity in lymphoid cells

1989 • 103 citations

Control of the higher eukaryote cell cycle by p34cdc2 homologues

1989 • 94 citations

Inhibition of apoptosis in human immunodeficiency virus-infected cells enhances virus production and facilitates persistent infection

1995 • 93 citations

Vpu-induced degradation of CD4: requirement for specific amino acid residues in the cytoplasmic domain of CD4

1993 • 91 citations

Generation and characterization of the human immunodeficiency virus type 1 mutants

1991 • 88 citations

Susceptibility to cytotoxic T lymphocyte-induced apoptosis is a function of the proliferative status of the target.

1994 • 77 citations

Rescue from granzyme B-induced apoptosis by Wee1 kinase.

1995 • 62 citations

Cell cycle control of apoptosis in human leukemic T cells.

1995 • 61 citations

Biological characterization of human immunodeficiency virus type 1 and type 2 mutants in human peripheral blood mononuclear cells

1992 • 52 citations

Vertebrate p34cdc2 phosphorylation site mutants: effects upon cell cycle progression in the fission yeast Schizosaccharomyces pombe

1992 • 41 citations

Cell cycle arrest by Colcemid differs in human normal and tumor cells.

1994 • 29 citations

Ligand-induced apoptosis of mature T lymphocytes (propriocidal regulation) occurs at distinct stages of the cell cycle.

1993 • 26 citations

Granzymes and Apoptosis: Targeting the Cell Cycle

1995 • 20 citations