Human immunodeficiency virus gp120 and derived peptides activate protein tyrosine kinase p56Ick in human CD4 T lymphocytes

The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus

1984 • 3,530 citations

T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV

1984 • 2,441 citations

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1988 • 1,442 citations

Delineation of a region of the human immunodeficiency virus type 1 gp120 glycoprotein critical for interaction with the CD4 receptor

1987 • 827 citations

Role of the HTLV-III/LAV envelope in syncytium formation and cytopathicity

1986 • 804 citations

The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes.

1988 • 716 citations

Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck

1989 • 671 citations

Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor.

1990 • 647 citations

Induction of CD4-dependent cell fusion by the HTLV-III/LAV envelope glycoprotein

1986 • 593 citations

Cell growth and differentiation

2005 • 226 citations

Inhibition of CD4+ T cell function by the HIV envelope protein, gp120.

1988 • 160 citations

HTLV-III large envelope protein (gp120) suppresses PHA-induced lymphocyte blastogenesis.

1987 • 160 citations

Cross-linking of T-cell surface molecules CD4 and CD8 stimulates phosphorylation of the lck tyrosine protein kinase at the autophosphorylation site.

1990 • 158 citations

Human immunodeficiency virus type 1 envelope glycoprotein gp120 produces immune defects in CD4+ T lymphocytes by inhibiting interleukin 2 mRNA.

1990 • 148 citations

The protein tyrosine kinase p56lck inhibits CD4 endocytosis by preventing entry of CD4 into coated pits

1992 • 141 citations

Tyrosyl Phosphorylation and Activation of MAP Kinases by p56^lck

1992 • 140 citations

Structural analysis of the human immunodeficiency virus-binding domain of CD4. Epitope mapping with site-directed mutants and anti-idiotypes.

1989 • 140 citations

Analysis of the site in CD4 that binds to the HIV envelope glycoprotein.

1990 • 132 citations

Association of the tyrosine kinase LCK with phospholipase C-gamma 1 after stimulation of the T cell antigen receptor.

1992 • 125 citations

Activators of Protein Kinase C Induce Dissociation of CD4, But Not CD8, from p56 ^lck

1989 • 111 citations

Alterations in tyrosine protein phosphorylation induced by antibody-mediated cross-linking of the CD4 receptor of T lymphocytes.

1989 • 103 citations

Participation of Tyrosine Phosphorylation in the Cytopathic Effect of Human Immunodeficiency Virus-1

1992 • 98 citations

Truncated variants of gp120 bind CD4 with high affinity and suggest a minimum CD4 binding region.

1992 • 92 citations

No T-cell tyrosine protein kinase signalling or calcium mobilization after CD4 association with HIV-1 or HIV-1 gp120

1990 • 90 citations

Effect of human immunodeficiency virus gp120 glycoprotein on the association of the protein tyrosine kinase p56lck with CD4 in human T lymphocytes

1991 • 86 citations

The lymphocyte‐specific protein tyrosine kinase p56^lck is hyperphosphorylated on serine and tyrosine residues within minutes after activation via T cell receptor or CD2

1989 • 80 citations

The CD4 associated tyrosine protein kinase p56lck is positively regulated through its site of autophosphorylation.

1990 • 73 citations

Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway.

1990 • 63 citations

The role of lymphocyte function‐associated antigen 1 (LFA‐1) in the adherence of T lymphocytes to B lymphocytes

1988 • 49 citations

Chemically induced CD4 mutants of a human T cell line. Evidence for dissociation between binding of HIV I envelope and susceptibility to HIV I infection and syncytia formation.

1990 • 40 citations

The Raf-1 serine-threonine kinase is a substrate for the p56lck protein tyrosine kinase in human T-cells.

1991 • 36 citations

Interaction of human immunodeficiency virus glycoprotein 160 with CD4 in Jurkat cells increases p56^lck autophosphorylation and kinase activity

1992 • 35 citations

The effect of p56^lck, a lymphocyte specific protein tyrosine kinase, on the syncytium formation induced by human immunodeficiency virus envelope glycoprotein

1992 • 28 citations

Inhibition of CD4+ T cell activation and adhesion by peptides derived from the gp160.

1991 • 22 citations

Accessory receptors regulate coupling of the T-cell receptor complex to tyrosine kinase activation and mobilization of cytoplasmic calcium in T- lineage acute lymphoblastic leukemia

1991 • 19 citations