Programmed death of T cells in human immunodeficiency virus infection. No correlation with progression to disease.

Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus population

1992 • 1,059 citations

Programmed Death of T Cells in HIV-1 Infection

1992 • 932 citations

Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes.

1987 • 923 citations

Activation-induced death by apoptosis in CD4+ T cells from human immunodeficiency virus-infected asymptomatic individuals.

1992 • 907 citations

Prognostic Value of HIV-1 Syncytium-Inducing Phenotype for Rate of CD4+ Cell Depletion and Progression to AIDS

1993 • 780 citations

The Reservoir for HIV-1 in Human Peripheral Blood Is a T Cell That Maintains Expression of CD4

1989 • 732 citations

Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis.

1992 • 689 citations

Programmed cell death and extrathymic reduction of Vβ8+CD4+ T cells in mice tolerant to Staphylococcus aureus enterotoxin B

1991 • 675 citations

Detection of three distinct patterns of T helper cell dysfunction in asymptomatic, human immunodeficiency virus-seropositive patients. Independence of CD4+ cell numbers and clinical staging.

1989 • 637 citations

Cell dysfunction and depletion in AIDS: the programmed cell death hypothesis

1991 • 548 citations

Differential expression of apoptosis-related Fas antigen on lymphocyte subpopulations in human peripheral blood.

1992 • 510 citations

Immunological abnormalities in human immunodeficiency virus (HIV)-infected asymptomatic homosexual men. HIV affects the immune system before CD4+ T helper cell depletion occurs.

1988 • 450 citations

Apoptosis as a mechanism of cell death in cultured T lymphoblasts acutely infected with HIV-1.

1991 • 432 citations

Induction of activation-driven death (apoptosis) in activated but not resting peripheral blood T cells.

1993 • 341 citations

Programmed Cell Death in AIDS-Related HIV and SIV Infections

1993 • 316 citations

Viral Phenotype and Immune Response in Primary Human Immunodeficiency Virus Type 1 Infection

1992 • 268 citations

Receptor-stimulated death pathway is opened by antigen in mature T cells.

1991 • 255 citations

Apoptotic cell death of primed CD45RO+ T lymphocytes in Epstein-Barr virus-induced infectious mononucleosis

1992 • 205 citations

Functional and phenotypic evidence for a selective loss of memory T cells in asymptomatic human immunodeficiency virus-infected men.

1990 • 198 citations

Numbers of CD4+ Cells and the Levels of Core Antigens of and Antibodies to the Human Immunodeficiency Virus as Predictors of AIDS Among Seropositive Homosexual Men

1988 • 186 citations

T-cell dysfunction in HIV infection: anergy due to defective antigen-presenting cell function?

1993 • 183 citations

Selective loss of T cell functions in different stages of HIV infection Early loss ofanti‐CD3‐induced T cell proliferation followed by decreased anti‐CD3‐induced cytotoxic T lymphocyte generation in AIDS‐related complex and AIDS

1990 • 149 citations

Programmed cell death of T lymphocytes during acute viral infection: a mechanism for virus-induced immune deficiency

1993 • 147 citations

Defective clonogenic potential of CD8+ T lymphocytes in patients with AIDS. Expansion in vivo of a nonclonogenic CD3+CD8+DR+CD25- T cell population.

1990 • 131 citations

Human CD8+ T lymphocytes can be divided into CD45RA+ and CD45RO+ cells with different requirements for activation and differentiation.

1991 • 118 citations

Reduced ecto-5'-nucleotidase activity and enhanced OKT10 and HLA-DR expression on CD8 (T suppressor/cytotoxic) lymphocytes in the acquired immune deficiency syndrome: evidence of CD8 cell immaturity.

1985 • 108 citations

Low T-cell responsiveness to activation via CD3/TCR is a prognostic marker for acquired immunodeficiency syndrome (AIDS) in human immunodeficiency virus-1 (HIV-1)-infected men

1990 • 104 citations

A chimpanzee-passaged human immunodeficiency virus isolate is cytopathic for chimpanzee cells but does not induce disease

1991 • 79 citations

Functional studies with anti-CD3 heavy chain isotype switch-variant monoclonal antibodies. Accessory cell-independent induction of interleukin 2 responsiveness in T cells by epsilon-anti-CD3.

1987 • 72 citations

Differential activation of antigen-stimulated suicide and cytokine production pathways in CD4+ T cells is regulated by the antigen-presenting cell.

1993 • 62 citations

T lymphocytes in infectious mononucleosis. I. T cell death in vitro.

1985 • 51 citations

Lymphocyte subset analysis to predict progression to AIDS in a cohort of homosexual men in San Francisco

1989 • 49 citations

The inability of human immunodeficiency virus to infect chimpanzee monocytes can be overcome by serial viral passage in vivo

1991 • 41 citations

HIV-related alterations in CD8 cell subsets defined by in Vitro survival characteristics

1991 • 27 citations

Apoptotic cell death of primed CD45RO+ T lymphocytes in Epstein-Barr virus-induced infectious mononucleosis

1992 • 13 citations

Differential activation of antigen-stimulated suicide and cytokine production pathways in CD4+ T cells is regulated by the antigen-presenting cell

1993 • 4 citations