Back to search

Decreased Frequency of Somatic Hypermutation and Impaired Affinity Maturation but Intact Germinal Center Formation in Mice Expressing Antisense RNA to DNA Polymerase ζ

Data up to Jan 2025

Published2001
Citations147
References69

Total Citations Per Year

Abstract

References (69)

Biometry: The Principles and Practice of Statistics in Biological Research

1969 • 21,227 citations

Biometry: The Principles and Practice of Statistics in Biological Research (2nd ed.).

1982 • 3,776 citations

Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme

2000 • 3,323 citations

Variations in Affinities of Antibodies during the Immune Response*

1964 • 1,078 citations

Maturation of the immune response in germinal centers

1991 • 904 citations

A new antigen receptor gene family that undergoes rearrangement and extensive somatic diversification in sharks

1995 • 691 citations

Thymine-Thymine Dimer Bypass by Yeast DNA Polymerase ζ

1996 • 655 citations

Monoclonal dinitrophenyl-specific murine IgE antibody: preparation, isolation, and characterization.

1980 • 653 citations

Mutation Drift and Repertoire Shift in the Maturation of the Immune Response

1987 • 635 citations

Eukaryotic polymerases ι and ζ act sequentially to bypass DNA lesions

2000 • 621 citations

Variability in the Lambda Light Chain Sequences of Mouse Antibody

1970 • 554 citations

A single VH gene segment encodes the immune response to phosphorylcholine: Somatic mutation is correlated with the class of the antibody

1981 • 470 citations

Somatic hyperconversion diversifies the single VH gene of the chicken with a high incidence in the D region

1989 • 467 citations

Somatic hypermutagenesis in immunoglobulin genes

1992 • 458 citations

Somatic Hypermutation of Immunoglobulin Genes Is Linked to Transcription Initiation

1996 • 424 citations

Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation

1999 • 402 citations

Developmental Control of Cell Cycle Regulators: A Fly's Perspective

1996 • 383 citations

Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region

1994 • 382 citations

Inter- and intraclonal diversity in the antibody response to influenza hemagglutinin.

1985 • 319 citations

Antisense RNA: Function and Fate of Duplex RNA in Cells of Higher Eukaryotes

1998 • 314 citations

Origin of Antibody Variation

1966 • 314 citations

A human homolog of the Saccharomyces cerevisiae REV3 gene, which encodes the catalytic subunit of DNA polymerase ζ

1998 • 300 citations

THE MECHANISM OF ANTIGENIC STIMULATION OF PRIMARY AND SECONDARY CLONAL PRECURSOR CELLS

1972 • 272 citations

Progress in immunology V

1985 • 268 citations

Cell-cycle-regulated DNA double-strand breaks in somatic hypermutation of immunoglobulin genes

2000 • 264 citations

Somatic Hypermutation Introduces Insertions and Deletions into Immunoglobulin V Genes

1998 • 259 citations

TdT-Accessible Breaks Are Scattered over the Immunoglobulin V Domain in a Constitutively Hypermutating B Cell Line

1998 • 255 citations

Clonal recruitment and somatic mutation in the generation of immunological memory to the hapten NP.

1986 • 227 citations

bcl-2 Transgene Expression Inhibits Apoptosis in the Germinal Center and Reveals Differences in the Selection of Memory B Cells and Bone Marrow Antibody-Forming Cells

2000 • 220 citations

Timing, Genetic Requirements and Functional Consequences of Somatic Hypermutation during B‐Cell Development

1987 • 218 citations

Primary antibody-forming cells and secondary B cells are generated from separate precursor cell subpopulations

1989 • 215 citations

A Role for REV3 in Mutagenesis During Double-Strand Break Repair in Saccharomyces cerevisiae

1997 • 201 citations

DNA Double-Strand Breaks in Immunoglobulin Genes Undergoing Somatic Hypermutation

2000 • 189 citations

Structure of primary anti‐(4‐hydroxy‐3‐nitro‐phenyl)acetyl (NP) antibodies in normal and idiotypically suppressed C57BL/6 mice

1985 • 184 citations

Analysis of the frequency and pattern of somatic mutations within nonproductively rearranged human variable heavy chain genes.

1997 • 180 citations

What limits affinity maturation of antibodies in Xenopus--the rate of somatic mutation or the ability to select mutants?

1992 • 179 citations

Disruption of the developmentally regulated Rev3l gene causes embryonic lethality

2000 • 175 citations

Idiotypic analysis of the response of C57BL/6 mice to the (4‐hydroxy‐3‐nitrophenyl)acetyl group

1977 • 171 citations

Antigen-Specific B Cell Memory

2000 • 170 citations

Inherited Immunoglobulin Idiotypes of the Mouse

1977 • 168 citations

Disruption of the Rev3l-encoded catalytic subunit of polymerase ζ in mice results in early embryonic lethality

2000 • 165 citations

Repair of Intermediate Structures Produced at DNA Interstrand Cross-Links in Saccharomyces cerevisiae

2000 • 162 citations

Patterns of Somatic Mutations in Immunoglobulin Variable Genes

1987 • 158 citations

Disruption of mouse polymerase ζ (Rev3) leads to embryonic lethality and impairs blastocyst development in vitro

2000 • 154 citations

Junctional Amino Acids Determine the Maturation Pathway of an Antibody

1999 • 151 citations

Evolution of Antibody Variable Region Structure during the Immune Response

1987 • 149 citations

Specificity of DNA Lesion Bypass by the Yeast DNA Polymerase η

2000 • 145 citations

Somatic hypermutation of immunoglobulin kappa may depend on sequences 3′ of C kappa and occurs on passenger transgenes.

1991 • 132 citations

Mutational pattern of the nurse shark antigen receptor gene (NAR) is similar to that of mammalian Ig genes and to spontaneous mutations in evolution: the translesion synthesis model of somatic hypermutation

1999 • 106 citations

Evolution of somatic hypermutation and gene conversion in adaptive immunity

1998 • 90 citations

Making (anti)sense of non-coding sequence conservation

1997 • 85 citations

Severe Attenuation of the B Cell Immune Response in Msh2-deficient Mice

1999 • 81 citations

Equine anti-hapten antibody. 3. The comparative properties of gamma G- and gammaA-antibodies.

1966 • 78 citations

Somatic mutation of immunoglobulin lambda chains: a segment of the major intron hypermutates as much as the complementarity-determining regions.

1994 • 69 citations

A Hypermutable Insert in an Immunoglobulin Transgene Contains Hotspots of Somatic Mutation and Sequences Predicting Highly Stable Structures in the RNA Transcript

1998 • 56 citations

Roles of DNA Polymerase and Rev1 Protein in Eukaryotic Mutagenesis and Translesion Replication

2000 • 53 citations

Clone: A Monte-Carlo Computer Simulation of B Cell Clonal Expansion, Somatic Mutation, and Antigen-Driven Selection

1998 • 50 citations

A selective increase in the generation of phosphorylcholine-specific B cells associated with aging.

1986 • 50 citations

Characterization of an endogenous RNA transcript with homology to the antisense strand of the human c-myc gene.

1992 • 43 citations

Saccharomyces cerevisiae lacking Snm1, Rev3 or Rad51 have a normal S-phase but arrest permanently in G2 after cisplatin treatment

2000 • 42 citations

Equine Anti-Hapten Antibody

1966 • 39 citations

Enhancers of hypermutation

1996 • 32 citations

Evolution and the molecular basis of somatic hypermutation of antigen receptor genes

2001 • 28 citations

Transfected rat cMOAT is functionally expressed on the apical membrane in Madin-Darby canine kidney (MDCK) cells.

1998 • 26 citations

Somatic hypermutagenesis in immunoglobulin genes. III. Somatic mutations in the chicken light chain locus

1996 • 23 citations

Differences in antibody repertoires for (4-hydroxy-3-nitrophenyl)acetyl (NP) in splenic vs immature bone marrow precursor cells.

1985 • 22 citations

hBRAG, a novel B cell lineage cDNA encoding a type II transmembrane glycoprotein potentially involved in the regulation of recombination activating gene 1 (RAG1)

1998 • 21 citations

Repair of Intermediate Structures Produced at DNA Interstrand Cross-Links in Saccharomyces cerevisiae

2000 • 10 citations

Splenic focus assay

1987 • 5 citations

Cited By (0)

Loading...