Maturation of the immune response in germinal centers

Sequences of proteins of immunological interest

1984 • 3,427 citations

Mechanism of antigen-driven selection in germinal centres

1989 • 1,097 citations

Recent Advances in the Polymerase Chain Reaction

1991 • 1,068 citations

The role of clonal selection and somatic mutation in autoimmunity

1987 • 714 citations

Mutation Drift and Repertoire Shift in the Maturation of the Immune Response

1987 • 635 citations

Cell Selection by Antigen in the Immune Response

1969 • 594 citations

Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin.

1984 • 545 citations

Somatic mutation and the maturation of immune response to 2-phenyl oxazolone

1984 • 534 citations

Surface Antigen Expression and Immunoglobulin Gene Rearrangement During Mouse pre‐B Cell Development

1983 • 490 citations

Antigen‐Driven Selection of Virgin and Memory B Cells

1986 • 476 citations

Rapid and quantitative preparation of cytoplasmic RNA from small numbers of cells

1988 • 406 citations

Molecular events during maturation of the immune response to oxazolone

1985 • 380 citations

Surface phenotype of Peyer's patch germinal center cells: implications for the role of germinal centers in B cell differentiation.

1982 • 320 citations

Origin of Antibody Variation

1966 • 314 citations

The Maintenance and Regulation of the Humoral Immune Response: Persisting Antigen and the Role of Follicular Antigen‐Binding Dendritic Cells as Accessory Cells

1980 • 313 citations

mRNA sequences define an unusually restricted IgG response to 2-phenyloxazolone and its early diversification

1983 • 301 citations

Relationship of germinal centers in lymphoid tissue to immunologic memory. VI. Transfer of B cell memory with lymph node cells fractionated according to their receptors for peanut agglutinin.

1983 • 274 citations

Peanut lectin binding properties of germinal centers of mouse lymphoid tissue

1980 • 259 citations

Analysis of somatic mutation and class switching in naive and memory B cells generating adoptive primary and secondary responses

1987 • 230 citations

Timing, Genetic Requirements and Functional Consequences of Somatic Hypermutation during B‐Cell Development

1987 • 218 citations

Somatic evolution of variable region structures during an immune response.

1986 • 211 citations

The repertoire of somatic antibody mutants accumulating in the memory compartment after primary immunization is restricted through affinity maturation and mirrors that expressed in the secondary response.

1990 • 200 citations

Structure of primary anti‐(4‐hydroxy‐3‐nitro‐phenyl)acetyl (NP) antibodies in normal and idiotypically suppressed C57BL/6 mice

1985 • 184 citations

Molecular characterization of single memory B cells

1991 • 163 citations

Three-dimensional structure determination of an anti-2-phenyloxazolone antibody: the role of somatic mutation and heavy/light chain pairing in the maturation of an immune response.

1990 • 145 citations

Is rapid proliferation in B centroblasts linked to somatic mutation in memory B cell clones?

1988 • 135 citations

Lymphatic Tissues and in Vivo Immune Responses

1991 • 129 citations

Isolation of high-affinity memory B cells: phycoerythrin as a probe for antigen-binding cells.

1987 • 126 citations

Germinal Center Reaction and B Lymphocytes: Morphology and Function

1990 • 111 citations

Activation of memory and virgin B cell clones in hyperimmune animals

1987 • 90 citations

Somatic mutations in antibodies expressed by germinal centre B cells early after primary immunization

1990 • 83 citations

Somatic Mutation in Anti‐Phosphorylcholine Antibodies

1987 • 82 citations

Light chain germ-line genes and the immune response to 2-phenyloxazolone.

1985 • 67 citations

Relationship of germinal centers in lymphoid tissue to immunologic memory. V. The effect of prednisolone administered after the peak of the primary response.

1971 • 61 citations

The molecular evolution of the immune response: idiotope‐specific suppression indicates that B cells express germ‐line‐encoded V genes prior to antigenic stimulation

1986 • 53 citations

Data analysis in flow cytometry

1986 • 51 citations

The Influence of Somatic Mutation on Clonal Expansion

1989 • 42 citations

Molecular analysis of clonal stability and longevity in B cell memory.

1989 • 30 citations

Development of B cell lineages during a primary anti-hapten immune response.

1990 • 27 citations

V genes of the primary antibody response of C57BL110 mice to the hapten phenyloxazolone

1988 • 22 citations

The initiation of germinal centre reactivity

1991 • 18 citations

Cell population kinetics of the germinal centres of lymph nodes of BALB/c mice.

1980 • 16 citations