Somatic hypermutagenesis in immunoglobulin genes

Somatic generation of antibody diversity

1983 • 3,275 citations

A hyperconversion mechanism generates the chicken light chain preimmune repertoire

1987 • 693 citations

Mutation Drift and Repertoire Shift in the Maturation of the Immune Response

1987 • 635 citations

Cruciform structures in supercoiled DNA

1981 • 545 citations

Nomenclature for incompletely specified bases in nucleic acid sequences: rcommendations 1984

1985 • 537 citations

Somatic mutation and the maturation of immune response to 2-phenyl oxazolone

1984 • 534 citations

Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene.

1990 • 318 citations

Origin of Antibody Variation

1966 • 314 citations

Somatic diversification of the chicken immunoglobulin light chain gene is limited to the rearranged variable gene segment

1987 • 278 citations

Somatic mutation of immunoglobulin light-chain variable-region genes

1981 • 184 citations

Patterns of Somatic Mutations in Immunoglobulin Variable Genes

1987 • 158 citations

Mutational specificity of alkylating agents and the influence of DNA repair

1990 • 157 citations

Distribution of Mutations around Rearranged Heavy-Chain Antibody Variable-Region Genes

1990 • 129 citations

Influence of neighbouring base sequence on N-methyl-N′-nitro-N-nitrosoguanidine mutagenesis in the lacI gene of Escherichia coli

1987 • 107 citations

O6-methylguanine mutation and repair is nonuniform. Selection for DNA most interactive with O6-methylguanine.

1986 • 96 citations

GENE CONVERSION AND THE GENERATION OF ANTIBODY DIVERSITY

1989 • 93 citations

Distribution of mutations around rearranged heavy-chain antibody variable-region genes.

1990 • 93 citations

Hypothesis: Somatic hypermutation by gene conversion via the error prone DNA→RNA→DNA information loop

1987 • 83 citations

Position of the rearranged V kappa and its 5' flanking sequences determines the location of somatic mutations in the J kappa locus.

1991 • 74 citations

Unique pattern of point mutations arising after gene transfer into mammalian cells.

1987 • 58 citations

Molecular biology: Eukaryotic genes—are they under torsional stress?

1983 • 51 citations

Analysis of somatic mutations in kappa transgenes.

1990 • 51 citations

Pecularities of immunoglobulin gene structures as a basis for somatic mutation emergence

1987 • 35 citations

Somatic hypermutagenesis in immunoglobulin genes. I. Correlation between somatic mutations and repeats. Somatic mutation properties and clonal selection

1991 • 28 citations