Mutation Drift and Repertoire Shift in the Maturation of the Immune Response

Sequences of proteins of immunological interest

1984 • 3,427 citations

Somatic generation of antibody diversity

1983 • 3,275 citations

Genes and Antibodies

1959 • 675 citations

Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines

1984 • 644 citations

Cell Selection by Antigen in the Immune Response

1969 • 594 citations

Transfer of specificity by murine α and β T-cell receptor genes

1986 • 568 citations

Variability in the Lambda Light Chain Sequences of Mouse Antibody

1970 • 554 citations

Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin.

1984 • 545 citations

Somatic mutation and the maturation of immune response to 2-phenyl oxazolone

1984 • 534 citations

Sequences of mouse immunoglobulin light chain genes before and after somatic changes

1978 • 495 citations

Antigen‐Driven Selection of Virgin and Memory B Cells

1986 • 476 citations

A single VH gene segment encodes the immune response to phosphorylcholine: Somatic mutation is correlated with the class of the antibody

1981 • 470 citations

Molecular events during maturation of the immune response to oxazolone

1985 • 380 citations

Antibody diversity: Somatic hypermutation of rearranged VH genes

1981 • 334 citations

Inter- and intraclonal diversity in the antibody response to influenza hemagglutinin.

1985 • 319 citations

Origin of Antibody Variation

1966 • 314 citations

mRNA sequences define an unusually restricted IgG response to 2-phenyloxazolone and its early diversification

1983 • 301 citations

Clustering of extensive somatic mutations in the variable region of an immunoglobulin heavy chain gene from a human B cell lymphoma

1986 • 279 citations

Effect of somatic mutation within translocated c-myc genes in Burkitt's lymphoma

1984 • 259 citations

Clusters of point mutations are found exclusively around rearranged antibody variable genes.

1983 • 233 citations

Clonal recruitment and somatic mutation in the generation of immunological memory to the hapten NP.

1986 • 227 citations

Complete sequence of constant and 3′ noncoding regions of an immunoglobulin mRNA using the dideoxynucleotide method of RNA sequencing

1978 • 211 citations

The T cell receptor: the α and β chains define idiotype, and antigen and MHC specificity

1985 • 198 citations

Lymphocyte Population Kinetics in the Mouse

1986 • 182 citations

Differences between germ-line and rearranged immunoglobulin Vκ coding sequences suggest a localized mutation mechanism

1981 • 161 citations

A network theory of the immune system

1975 • 153 citations

Somatic mutation and clonal expansion of B cells in an antigen-driven immune response.

1985 • 153 citations

Hypermutation at the immunoglobulin heavy chain locus in a pre-B-cell line.

1985 • 150 citations

SEQUENTIAL CHANGES IN THE RELATIVE AFFINITY OF ANTIBODIES SYNTHESIZED DURING THE IMMUNE RESPONSE

1967 • 122 citations

Molecular analysis of spontaneous somatic mutants

1977 • 120 citations

Influence of Clonal Selection on the Expression of Immunoglobulin Variable Region Genes

1984 • 120 citations

A new classification of mouse VH sequences

1984 • 119 citations

Anti-oxazolone hybridomas and the structure of the oxazolone idiotype.

1983 • 114 citations

Antigen-binding mutants of mouse myeloma cells.

1977 • 82 citations

Different joining region J elements of the murine kappa immunoglobulin light chain locus are used at markedly different frequencies.

1984 • 79 citations

Light chain germ-line genes and the immune response to 2-phenyloxazolone.

1985 • 67 citations

Specific interaction between VH and VL regions of human monoclonal immunoglobulins

1976 • 60 citations

Somatic Mutants and Antibody Diversity

1977 • 53 citations

Several V genes participate in the early phenyloxazolone response in various combinations

1986 • 35 citations

Structural basis for the association of heavy and light chains and the relation of subgroups to the conformation of the active site of immunoglobulins

1975 • 24 citations

The Analysis of Structural Diversity in the Antibody Response

1985 • 13 citations

Molecular events during the onset and maturation of the antibody response.

1986 • 6 citations