A Hypermutable Insert in an Immunoglobulin Transgene Contains Hotspots of Somatic Mutation and Sequences Predicting Highly Stable Structures in the RNA Transcript

On Finding All Suboptimal Foldings of an RNA Molecule

1989 • 2,019 citations

Germinal Centers

1994 • 1,680 citations

The C-terminal domain of RNA polymerase II couples mRNA processing to transcription

1997 • 905 citations

Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1)

1997 • 779 citations

Mutation ofBCL-6Gene in Normal B Cells by the Process of Somatic Hypermutation of Ig Genes

1998 • 536 citations

Somatic hypermutagenesis in immunoglobulin genes

1992 • 458 citations

BASIC MECHANISMS OF TRANSCRIPT ELONGATION AND ITS REGULATION

1997 • 441 citations

The RNA–DNA Hybrid Maintains the Register of Transcription by Preventing Backtracking of RNA Polymerase

1997 • 431 citations

Somatic Hypermutation of Immunoglobulin Genes Is Linked to Transcription Initiation

1996 • 424 citations

The characterization of a mammalian DNA structure-specific endonuclease.

1994 • 406 citations

Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region

1994 • 382 citations

Increased Hypermutation at G and C Nucleotides in Immunoglobulin Variable Genes from Mice Deficient in the MSH2 Mismatch Repair Protein

1998 • 183 citations

Analysis of the frequency and pattern of somatic mutations within nonproductively rearranged human variable heavy chain genes.

1997 • 180 citations

Di- and trinucleotide target preferences of somatic mutagenesis in normal and autoreactive B cells.

1996 • 175 citations

Patterns of Somatic Mutations in Immunoglobulin Variable Genes

1987 • 158 citations

The Transcriptional Promoter Regulates Hypermutation of the Antibody Heavy Chain Locus

1997 • 142 citations

Hypermutation of Immunoglobulin Genes in Memory B Cells of DNA Repair–deficient Mice

1998 • 116 citations

Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2

1998 • 105 citations

The molecular basis of somatic hypermutation of immunoglobulin genes

1996 • 100 citations

The germinal center reaction

1995 • 94 citations

Somatic Hypermutation of Immunoglobulin Genes is Linked to Transcription

1998 • 84 citations

Modifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutation

1996 • 63 citations

Analysis of somatic mutations in kappa transgenes.

1990 • 51 citations

B Lymphocytes of Xeroderma Pigmentosum or Cockayne Syndrome Patients with Inherited Defects in Nucleotide Excision Repair Are Fully Capable of Somatic Hypermutation of Immunoglobulin Genes

1997 • 45 citations

Somatic hypermutation of Ig genes in patients with xeroderma pigmentosum (XP-D)

1996 • 45 citations

The Role of DNA Repair in Somatic Hypermutation of Immunoglobulin Genes

1998 • 45 citations

The inactivation of the XP-C gene does not affect somatic hypermutation or class switch recombination of immunoglobulin genes

1997 • 27 citations

Somatic hypermutation of an artificial test substrate within an Ig kappa transgene.

1998 • 21 citations

Somatic Hypermutation of an Artificial Test Substrate Within an Igκ Transgene

1998 • 19 citations