HLA-DM Interactions with Intermediates in HLA-DR Maturation and a Role for HLA-DM in Stabilizing Empty HLA-DR Molecules

Antigen-Presenting Function of the Macrophage

1984 • 1,164 citations

Two populations of Ia-like molecules on a human B cell line.

1980 • 1,112 citations

Assembly, Transport, and Function of MHC Class II Molecules

1994 • 791 citations

HLA-DM induces clip dissociation from MHC class II αβ dimers and facilitates peptide loading

1995 • 684 citations

Use of a Monoclonal Antibody (W6/32) in Structural Studies of HLA-A,B,C Antigens

1979 • 682 citations

Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments

1991 • 663 citations

The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3

1995 • 583 citations

Genes regulating HLA class I antigen expression in T-B lymphoblast hybrids

1985 • 580 citations

MHC class II-associated invariant chain contains a sorting signal for endosomal compartments

1990 • 565 citations

Mediation by HLA-DM of dissociation of peptides from HLA-DR

1995 • 555 citations

Essential Role for Cathepsin S in MHC Class II–Associated Invariant Chain Processing and Peptide Loading

1996 • 523 citations

Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytes

1994 • 442 citations

Isolation and characterization of the intracellular MHC class II compartment

1994 • 426 citations

MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen binding

1991 • 394 citations

HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides

1992 • 380 citations

Antigen processing and class II MHC peptide-loading compartments in human B-lymphoblastoid cells

1994 • 349 citations

Mice Lacking H2-M Complexes, Enigmatic Elements of the MHC Class II Peptide-Loading Pathway

1996 • 337 citations

Role for intracellular proteases in the processing and transport of class II HLA antigens.

1988 • 336 citations

H2-M Mutant Mice Are Defective in the Peptide Loading of Class II Molecules, Antigen Presentation, and T Cell Repertoire Selection

1996 • 331 citations

Formation of a nine-subunit complex by HLA class II glycoproteins and the invariant chain

1991 • 326 citations

Article

1995 • 325 citations

The human class II MHC protein HLA-DR1 assembles as empty αβ heterodimers in the absence of antigenic peptide

1992 • 306 citations

Antigen Presentation and T Cell Development in H2-M-Deficient Mice

1996 • 263 citations

A new human HLA class II-related locus, DM

1991 • 251 citations

Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells

1994 • 247 citations

Accumulation of HLA-DM, a regulator of antigen presentation, in MHC class II compartments

1994 • 244 citations

Separation of subcellular compartments containing distinct functional forms of MHC class II.

1994 • 221 citations

Inhibition of endosomal proteolytic activity by leupeptin blocks surface expression of MHC class II molecules and their conversion to SDS resistance alpha beta heterodimers in endosomes.

1992 • 219 citations

Invariant Chain Peptides in Most HLA-DR Molecules of an Antigen-Processing Mutant

1992 • 218 citations

Detection of a common polypeptide chain in I-A and I-E sub-region immunoprecipitates

1979 • 217 citations

A lysosomal targeting signal in the cytoplasmic tail of the beta chain directs HLA-DM to MHC class II compartments.

1995 • 198 citations

Assembly and transport properties of invariant chain trimers and HLA-DR-invariant chain complexes.

1992 • 189 citations

Antigen capture and major histocompatibility class II compartments of freshly isolated and cultured human blood dendritic cells.

1995 • 185 citations

In vivo and in vitro formation and dissociation of HLA-DR complexes with invariant chain-derived peptides

1994 • 185 citations

The CLIP region of invariant chain plays a critical role in regulating major histocompatibility complex class II folding, transport, and peptide occupancy.

1994 • 184 citations

Differential expression and serologically distinct subpopulations of human Ia antigens detected with monoclonal antibodies to Ia alpha and beta chains

1982 • 183 citations

Endosomal aspartic proteinases are required for invariant-chain processing.

1994 • 182 citations

Peptide binding inhibits protein aggregation of invariant-chain free class II dimers and promotes surface expression of occupied molecules

1993 • 157 citations

Biosynthesis and glycosylation of the invariant chain associated with HLA-DR antigens.

1982 • 155 citations

Association Between HLA-DM and HLA-DR In Vivo

1996 • 149 citations

A role for calnexin (IP90) in the assembly of class II MHC molecules.

1994 • 144 citations

Reconstitution of an operational MHC class II compartment in nonantigen-presenting cells

1994 • 135 citations

MHC class II function preserved by low-affinity peptide interactions preceding stable binding

1994 • 135 citations

New class ll-like genes in the murine MHC

1991 • 129 citations

The antigen-processing mutant T2 suggests a role for MHC-linked genes in class II antigen presentation.

1992 • 125 citations

Monoclonal Antibody to HLA-A3

1982 • 115 citations

A gene required for class II-restricted antigen presentation maps to the major histocompatibility complex.

1991 • 106 citations

Developing and shedding inhibitions: how MHC class II molecules reach maturity

1996 • 97 citations

The MHC class II molecule H2-M is targeted to an endosomal compartment by a tyrosine-based targeting motif

1995 • 94 citations

A mutant human histocompatibility leukocyte antigen DR molecule associated with invariant chain peptides.

1994 • 91 citations

Monensin prevents terminal glycosylation of the N- and O-linked oligosaccharides of the HLA-DR-associated invariant chain and inhibits its dissociation from the alpha-beta chain complex.

1984 • 90 citations

Transport and intracellular distribution of MHC class II molecules and associated invariant chain in normal and antigen-processing mutant cell lines.

1994 • 77 citations

Analysis of the oligosaccharides on the HLA-DR and DC1 B cell antigens.

1983 • 70 citations

Invariant chain made in Escherichia coli has an exposed N-terminal segment that blocks antigen binding to HLA-DR1 and a trimeric C-terminal segment that binds empty HLA-DR1.

1995 • 51 citations

A segment of the MHC class II β chain plays a critical role in targeting class II molecules to the endocytic pathway

1994 • 50 citations

Variation in HLA-DM expression influences conversion of MHC class II alpha beta:class II-associated invariant chain peptide complexes to mature peptide-bound class II alpha beta dimers in a normal B cell line.

1996 • 32 citations

Trafficking of major histocompatibility complex class II molecules through intracellular compartments containing HLA-DM

1996 • 24 citations