Transient Aggregation of Major Histocompatibility Complex Class II Chains during Assembly in Normal Spleen Cells

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Method for Determining the Sedimentation Behavior of Enzymes: Application to Protein Mixtures

1961 • 5,561 citations

Protein folding in the cell

1992 • 4,138 citations

An hsp70-like protein in the ER: Identity with the 78 kd glucose-regulated protein and immunoglobulin heavy chain binding protein

1986 • 1,457 citations

Protein Oligomerization in the Endoplasmic Reticulum

1989 • 993 citations

Posttranslational association of immunoglobulin heavy chain binding protein with nascent heavy chains in nonsecreting and secreting hybridomas.

1986 • 896 citations

Control of Protein Exit from the Endoplasmic Reticulum

1989 • 794 citations

Assembly, Transport, and Function of MHC Class II Molecules

1994 • 791 citations

Monoclonal xenogeneic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigens

1978 • 589 citations

Association of folding intermediates of glycoproteins with calnexin during protein maturation

1993 • 558 citations

Intracellular transport of class II MHC molecules directed by invariant chain

1990 • 548 citations

Calnexin: a membrane-bound chaperone of the endoplasmic reticulum

1994 • 533 citations

Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding

1990 • 486 citations

Mice lacking the MHC class II-associated invariant chain

1993 • 385 citations

Regulation of MHC Class I Transport by the Molecular Chaperone, Calnexin (p88, IP90)

1994 • 351 citations

Role for intracellular proteases in the processing and transport of class II HLA antigens.

1988 • 336 citations

Formation of a nine-subunit complex by HLA class II glycoproteins and the invariant chain

1991 • 326 citations

Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression.

1993 • 326 citations

Folding of VSV G Protein: Sequential Interaction with BiP and Calnexin

1994 • 316 citations

Invariant chain distinguishes between the exogenous and endogenous antigen presentation pathways

1990 • 303 citations

Retention of Unassembled Components of Integral Membrane Proteins by Calnexin

1994 • 243 citations

Proteolysis of the class II-associated invariant chain generates a peptide binding site in intracellular HLA-DR molecules.

1991 • 234 citations

Flow cytometry as an analytical and preparative tool in immunology

1982 • 220 citations

Inhibition of endosomal proteolytic activity by leupeptin blocks surface expression of MHC class II molecules and their conversion to SDS resistance alpha beta heterodimers in endosomes.

1992 • 219 citations

Regulating the retention of T-cell receptor alpha chain variants within the endoplasmic reticulum: Ca(2+)-dependent association with BiP.

1991 • 210 citations

Cooperative interaction of B lymphocytes with antigen-specific helper T lymphocytes is MHC restricted

1981 • 207 citations

Invariant chain can function as a chaperone protein for class II major histocompatibility complex molecules.

1992 • 197 citations

The invariant chain is required for intracellular transport and function of major histocompatibility complex class II molecules.

1994 • 196 citations

Assembly and transport properties of invariant chain trimers and HLA-DR-invariant chain complexes.

1992 • 189 citations

Misfolding and aggregation of newly synthesized proteins in the endoplasmic reticulum.

1992 • 177 citations

Invariant chain trimers are sequestered in the rough endoplasmic reticulum in the absence of association with HLA class II antigens.

1990 • 149 citations

HLA-DR associates with specific stress proteins and is retained in the endoplasmic reticulum in invariant chain negative cells.

1992 • 148 citations

Primary structure of the gene for the murine Ia antigen-associated invariant chains (Ii). An alternatively spliced exon encodes a cysteine-rich domain highly homologous to a repetitive sequence of thyroglobulin.

1987 • 147 citations

Invariant chain targets HLA class II molecules to acidic endosomes containing internalized influenza virus.

1991 • 146 citations

Relationship between invariant chain expression and major histocompatibility complex class II transport into early and late endocytic compartments.

1993 • 146 citations

Ia invariant chain detected on lymphocyte surfaces by monoclonal antibody

1982 • 145 citations

A role for calnexin (IP90) in the assembly of class II MHC molecules.

1994 • 144 citations

Posttranslational folding of vesicular stomatitis virus G protein in the ER: involvement of noncovalent and covalent complexes.

1993 • 113 citations

Association between calnexin and a secretion-incompetent variant of human alpha 1-antitrypsin.

1994 • 112 citations

Transient aggregation of nascent thyroglobulin in the endoplasmic reticulum: relationship to the molecular chaperone, BiP.

1992 • 112 citations

Association with BiP and aggregation of class II MHC molecules synthesized in the absence of invariant chain.

1994 • 104 citations

Invariant chain promotes egress of poorly expressed, haplotype-mismatched class II major histocompatibility complex A alpha A beta dimers from the endoplasmic reticulum/cis-Golgi compartment.

1991 • 94 citations

Chaperone function of calnexin for the folding intermediate of gp80, the major secretory protein in MDCK cells. Regulation by redox state and ATP.

1994 • 65 citations

Class II histocompatibility molecules associate with calnexin during assembly in the endoplasmic reticulum

1994 • 59 citations

Defective intracellular transport as a common mechanism limiting expression of inappropriately paired class II major histocompatibility complex alpha/beta chains.

1991 • 52 citations

Characterization of fragments of the murine Ia-associated invariant chain.

1991 • 49 citations

Time Course of Intracellular Associations, Processing, and Cleavages of Ii Forms and Class II Major Histocompatibility Complex Molecules

1989 • 39 citations

Implications of the invariant gamma-chain on the intracellular transport of class II histocompatibility antigens.

1985 • 38 citations

Invariant chain influences post-translational processing of HLA-DR molecules.

1991 • 35 citations

Specific binding of antigenic peptides to separate alpha and beta chains of class II molecules of the major histocompatibility complex.

1990 • 32 citations

Early disulfide bond formation prevents heterotypic aggregation of membrane proteins in a cell-free translation system.

1992 • 24 citations