Tumor-Induced Macrophage Tumor Necrosis Factor-α Production Suppresses Autoreactive T Cell Proliferation

Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.

1988 • 2,865 citations

The Pathophysiology of Tumor Necrosis Factors

1992 • 1,880 citations

Tumour necrosis factor-α in murine autoimmune 'lupus' nephritis

1988 • 599 citations

Prostaglandins modulate macrophage Ia expression

1982 • 545 citations

Prostaglandins as endogenous mediators of interleukin 1 production.

1986 • 541 citations

Cytotoxic mechanism of tumor necrosis factor‐α

1990 • 539 citations

Recombinant human TNF induces production of granulocyte–monocyte colony-stimulating factor

1986 • 528 citations

Immunoregulatory activity of recombinant human tumor necrosis factor (TNF)-alpha: induction of TNF receptors on human T cells and TNF-alpha-mediated enhancement of T cell responses.

1987 • 490 citations

EVIDENCE FOR TUMOUR NECROSIS FACTOR/CACHECTIN PRODUCTION IN CANCER

1987 • 425 citations

Tumor necrosis factor stimulates interleukin-1 and prostaglandin E2 production in resting macrophages

1986 • 344 citations

Enhancement of antigen- and mitogen-induced human T lymphocyte proliferation by tumor necrosis factor-alpha.

1988 • 221 citations

Serum-free in vitro bioassay for the detection of tumor necrosis factor

1986 • 195 citations

Tumor necrosis factor (TNF)-alpha but not TNF-beta induces secretion of colony stimulating factor for macrophages (CSF-1) by human monocytes

1987 • 191 citations

Chronic therapy with recombinant tumor necrosis factor-α in autoimmune NZB/NZW F1 mice

1989 • 169 citations

Immunomodulatory properties of recombinant murine and human tumor necrosis factor.

1988 • 128 citations

Autologous Mixed Lymphocyte Reaction in Patients with Hodgkin's Disease

1980 • 126 citations

Production of colony-stimulating factor by tumor cells and the factor-mediated induction of suppressor cells.

1988 • 112 citations

Suppressor cell activity in tumor-bearing mice. I. Dualistic inhibition by suppressor T lymphocytes and macrophages.

1978 • 111 citations

Relationships of prostaglandin E and natural killer sensitivity to metastatic potential in murine mammary adenocarcinomas.

1985 • 102 citations

Regulation of MHC class II antigen expression. Opposing effects of tumor necrosis factor-alpha on IFN-gamma-induced HLA-DR and Ia expression depends on the maturation and differentiation stage of the cell.

1991 • 99 citations

Human T cells from autoimmune and normal individuals can produce tumor necrosis factor

1987 • 94 citations

Effects of recombinant murine tumor necrosis factor-alpha on immune function.

1990 • 89 citations

Significance of Self‐Recognition and Interleukin‐2 for Immunoregulation, Autoimmunity and Cancer

1982 • 87 citations

Tumor Necrosis Factor-α Induces Increased Hydrogen Peroxide Production and Fc Receptor Expression, but Not Increased la Antigen Expression by Peritoneal Macrophages

1987 • 83 citations

Tumor necrosis factor-induced activation of peritoneal macrophages is regulated by prostaglandin E2 and cAMP.

1988 • 82 citations

Comparative effects of tumor necrosis factor-alpha and IL-1 beta on mitogen-induced T cell activation.

1988 • 81 citations

Tumor necrosis factor-alpha as a proliferative signal for an IL-2-dependent T cell line: strict species specificity of action.

1989 • 74 citations

Prostaglandin E2 inhibits human T-cell proliferation after crosslinking of the CD3-Ti complex by directly affecting T cells at an early step of the activation process

1987 • 70 citations

Prostaglandin E Production by Lewis Lung Carcinoma: Mechanism for Tumor Establishment In Vivo<xref ref-type="fn" rid="FN2">2</xref>

1984 • 61 citations

An autoreactive T cell clone that can be activated to provide both helper and suppressor function.

1986 • 58 citations

Combined effects of tumor necrosis factor-alpha, prostaglandin E2, and corticosterone on induced Ia expression on murine macrophages.

1990 • 37 citations

Tumor growth increases la− macrophage synthesis of tumor necrosis factor-α and prostaglandin E2: changes in macrophage suppressor activity

1993 • 37 citations

Shifts in macrophage (Mφ) surface phenotypes during tumor growth: Association of Mac-2+ and Mac-3+ Mφ with immunosuppressive activity

1987 • 35 citations

Characterization and function of autoreactive T-lymphocyte clones isolated from normal, unprimed mice

1985 • 33 citations

Down-Regulation of Macrophage I-A Expression in Tumor-Bearing Mice

1990 • 24 citations

Tumor-induced alteration in macrophage accessory cell activity on autoreactive T cells

1989 • 23 citations

An analysis of autologous T‐cell anti‐tumour responses in colon‐carcinoma patients following active specific immunization (ASI)

1992 • 22 citations

Suppressor Cell Activity in Tumor-Bearing Mice

1978 • 17 citations

Tumor-induced modulation of macrophage class II MHC molecule mRNA expression

1993 • 15 citations

IA⁻Macrophages and Cytokine Networks Contribute to Tumor-Induced Suppression of CD4⁺Autoreactive T Cells

1993 • 14 citations

Characterization of autoreactive T cells. Relative importance of self-peptides versus MHC.

1991 • 9 citations

Tumor growth changes the contribution of granulocyte-macrophage colony-stimulating factor during macrophage-mediated suppression of allorecognition

1992 • 8 citations

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