The role of nitric oxide in cancer

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

1987 • 5,027 citations

NITRIC OXIDE AND MACROPHAGE FUNCTION

1997 • 4,106 citations

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

1999 • 3,529 citations

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

1999 • 2,577 citations

Macrophage Cytotoxicity: Role for L-Arginine Deiminase and Imino Nitrogen Oxidation to Nitrite

1987 • 1,533 citations

Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase

2000 • 1,411 citations

Melanoma Cell Expression of Fas(Apo-1/CD95) Ligand: Implications for Tumor Immune Escape

1996 • 1,281 citations

DNA Deaminating Ability and Genotoxicity of Nitric Oxide and its Progenitors

1991 • 1,223 citations

Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide.

1985 • 1,146 citations

Nitric Oxide Activation of Poly(ADP-Ribose) Synthetase in Neurotoxicity

1994 • 1,138 citations

Dynamic activation of endothelial nitric oxide synthase by Hsp90

1998 • 1,016 citations

Inducible nitric oxide synthase: what difference does it make?

1997 • 964 citations

The DNA-dependent protein kinase

1999 • 896 citations

Roles of nitric oxide in tumor growth.

1995 • 791 citations

Stimulation of guanylate cyclase by sodium nitroprusside, nitroglycerin and nitric oxide in various tissue preparations and comparison to the effects of sodium azide and hydroxylamine.

1977 • 692 citations

Nitric oxide synthase activity in human breast cancer

1995 • 637 citations

Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in Barrett's esophagus and associated adenocarcinomas.

1998 • 595 citations

Virus treatment questioned after gene therapy death

1999 • 578 citations

Membrane Estrogen Receptor Engagement Activates Endothelial Nitric Oxide Synthase via the PI3-Kinase–Akt Pathway in Human Endothelial Cells

2000 • 558 citations

Frequent nitric oxide synthase-2 expression in human colon adenomas: implication for tumor angiogenesis and colon cancer progression.

1998 • 471 citations

Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53.

1996 • 455 citations

Nitric oxide synthase activity in human gynecological cancer.

1994 • 428 citations

Expression of nitric oxide synthase in human central nervous system tumors.

1995 • 370 citations

Transfection with the inducible nitric oxide synthase gene suppresses tumorigenicity and abrogates metastasis by K-1735 murine melanoma cells.

1995 • 326 citations

DNA-dependent protein kinase acts upstream of p53 in response to DNA damage

1998 • 313 citations

Local endostatin treatment of gliomas administered by microencapsulated producer cells

2001 • 303 citations

p53 and vascular endothelial growth factor regulate tumor growth of NOS2-expressing human carcinoma cells

1998 • 279 citations

Interactive effects of nitric oxide and the p53 tumor suppressor gene in carcinogenesis and tumor progression

1997 • 234 citations

NITRO-GLYCERINE AS A REMEDY FOR ANGINA PECTORIS.

1879 • 215 citations

Selective expression of inducible nitric oxide synthase in human prostate carcinoma

1998 • 203 citations

Inducible nitric oxide synthase expression, apoptosis, and angiogenesis in in situ and invasive breast carcinomas.

2000 • 194 citations

Blood nitrates and infantile methemoglobinemia

1982 • 175 citations

Up-regulation of inducible nitric oxide synthase expression in cancer-prone p53 knockout mice

1998 • 166 citations

Relationships between caveolae and eNOS: everything in proximity and the proximity of everything

2002 • 155 citations

Nitric oxide upregulates expression of DNA-PKcs to protect cells from DNA-damaging anti-tumour agents

2000 • 125 citations

Vascular endothelial growth factor and nitric oxide synthase expression in human lung cancer and the relation to p53

1998 • 124 citations

Nitric oxide synthase in human breast cancer is associated with tumor grade, proliferation rate, and expression of progesterone receptors.

1999 • 119 citations

Immunohistochemical characterizationof nitric oxide synthase activity in squamous cell carcinoma of the head and neck

1995 • 110 citations

Role of nitric oxide in pancreatic tumour growth: in vivo and in vitro studies

1998 • 110 citations

Microencapsulated iNOS‐expressing cells cause tumor suppression in mice

2001 • 109 citations

Lack of inducible nitric oxide synthase promotes intestinal tumorigenesis in the ApcMin/+ mouse

2001 • 96 citations

Nitric Oxide Sensitizes Ovarian Tumor Cells to Fas-Induced Apoptosis

1999 • 95 citations

INDUCIBLE NITRIC OXIDE SYNTHASE WITH TRANSITIONAL CELL CARCINOMA OF THE BLADDER

1999 • 95 citations

Suppression of Tumorigenicity and Metastasis of Human Renal Carcinoma Cells by Infection with Retroviral Vectors Harboring the Murine Inducible Nitric Oxide Synthase Gene

1998 • 89 citations

Expression of endothelial and inducible nitric oxide synthase in benign and malignant lesions of the breast and measurement of nitric oxide using electron paramagnetic resonance spectroscopy

2002 • 82 citations

Hippocampal neurons of mice deficient in DNA-dependent protein kinase exhibit increased vulnerability to DNA damage, oxidative stress and excitotoxicity

2001 • 79 citations

Aberrant expression of nitric oxide synthase in human polyps, neoplastic colonic mucosa and surrounding peritumoral normal mucosa

1994 • 75 citations

Endothelial Nitric Oxide Synthase: Correlation with Histologic Grade, Lymph Node Status and Estrogen Receptor Expression in Human Breast Cancer

2000 • 60 citations

Therapy of Human Ovarian Cancer by Transfection with the Murine InterferonβGene: Role of Macrophage-Inducible Nitric Oxide Synthase

1998 • 50 citations

eNOS expression is associated with the estrogen and progesterone receptor status in invasive breast carcinoma.

2000 • 44 citations

Deoxyribonucleic acid damage/repairproteins are elevated in the failing human myocardium due to idiopathic dilated cardiomyopathy

2002 • 43 citations

Vascular inducible nitric oxide synthase gene therapy: Requirement for guanosine triphosphate cyclohydrolase I

1996 • 37 citations

Nitric oxide synthases in Kaposi's sarcoma are expressed predominantly by vessels and tissue macrophages.

1998 • 34 citations

Mammalian nitrate biochemistry: metabolism and endogenous synthesis.

1984 • 33 citations

Nitric Oxide: from a mysterious labile factor to the molecule of the Nobel Prize

1998 • 27 citations

Rôle pro- et anti-apoptotique du monoxyde d’azote, NO

2001 • 6 citations