Anterior-posterior patterning in the Drosophila embryo

A comprehensive analysis of protein–protein interactions in Saccharomyces cerevisiae

2000 • 4,734 citations

Mutations affecting segment number and polarity in Drosophila

1980 • 4,280 citations

A gene complex controlling segmentation in Drosophila

1978 • 3,668 citations

The development of Drosophila melanogaster

1994 • 3,057 citations

DEVELOPMENT IN DROSOPHILA MELANOGASTER

1927 • 2,909 citations

Universal control mechanism regulating onset of M-phase

1990 • 2,882 citations

A generic protein purification method for protein complex characterization and proteome exploration

1999 • 2,699 citations

Homeobox genes and axial patterning

1992 • 2,688 citations

The embryonic development of Drosophila melanogaster

1938 • 2,188 citations

Methylation-Induced Repression— Belts, Braces, and Chromatin

1999 • 1,823 citations

The Tandem Affinity Purification (TAP) Method: A General Procedure of Protein Complex Purification

2001 • 1,792 citations

Gene Activity in Early Development

1968 • 1,725 citations

Genome-Wide Location and Function of DNA Binding Proteins

2000 • 1,720 citations

A major developmental transition in early xenopus embryos: I. characterization and timing of cellular changes at the midblastula stage

1982 • 1,635 citations

Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster

1984 • 1,546 citations

Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25

1997 • 1,285 citations

Armadillo Coactivates Transcription Driven by the Product of the Drosophila Segment Polarity Gene dTCF

1997 • 1,201 citations

Genomic binding sites of the yeast cell-cycle transcription factors SBF and MBF

2001 • 1,101 citations

A major developmental transition in early xenopus embryos: II. control of the onset of transcription

1982 • 1,065 citations

Studies of nuclear and cytoplasmic behaviour during the five mitotic cycles that precede gastrulation in Drosophila embryogenesis

1983 • 1,034 citations

A gradient of bicoid protein in Drosophila embryos

1988 • 1,015 citations

brahma: A regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2SWI2

1992 • 951 citations

Coactivator and corepressor complexes in nuclear receptor function

1999 • 909 citations

Fluorescence resonance energy transfer

1995 • 878 citations

Protein-protein interactions: methods for detection and analysis

1995 • 812 citations

oskar organizes the germ plasm and directs localization of the posterior determinant nanos

1991 • 804 citations

Toward a protein–protein interaction map of the budding yeast: A comprehensive system to examine two-hybrid interactions in all possible combinations between the yeast proteins

2000 • 799 citations

Developmental Compartmentalisation of the Wing Disk of Drosophila

1973 • 770 citations

Protein Interaction Mapping in C. elegans Using Proteins Involved in Vulval Development

2000 • 769 citations

High-Mobility-Group Chromosomal Proteins: Architectural Components That Facilitate Chromatin Function

1996 • 752 citations

The role of localization of bicoid RNA in organizing the anterior pattern of the Drosophila embryo.

1988 • 736 citations

Drosophila Tcf and Groucho interact to repress Wingless signalling activity

1998 • 722 citations

The bicoid protein is a positive regulator of hunchback transcription in the early Drosophila embryo

1989 • 672 citations

Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster

1984 • 671 citations

Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split.

1992 • 667 citations

The Embryonic Development of Drosophila melanogaster

1997 • 661 citations

The gradient morphogen bicoid is a concentration-dependent transcriptional activator

1989 • 655 citations

Regulation of Hormone-Induced Histone Hyperacetylation and Gene Activation via Acetylation of an Acetylase

1999 • 630 citations

PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene.

1993 • 621 citations

Molecular Genetics of the Bithorax Complex in Drosophila melanogaster

1983 • 616 citations

Identification of in vivo DNA targets of chromatin proteins using tethered Dam methyltransferase

2000 • 591 citations

Genetic Control of Wing Disc Development in Drosophila

1975 • 584 citations

Dissection of the methyl-CpG binding domain from the chromosomal protein MeCP2

1993 • 584 citations

oskar mRNA is localized to the posterior pole of the Drosophila oocyte

1991 • 574 citations

Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins

1994 • 560 citations

Cdc25 Mitotic Inducer Targeted by Chk1 DNA Damage Checkpoint Kinase

1997 • 541 citations

Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster

1984 • 538 citations

Regulation of even-skipped stripe 2 in the Drosophila embryo.

1992 • 522 citations

Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation

1999 • 518 citations

Genetic organization of Drosophila bithorax complex

1985 • 514 citations

Nanos is the localized posterior determinant in Drosophila

1991 • 510 citations

A molecular gradient in early Drosophila embryos and its role in specifying the body pattern

1986 • 504 citations

The sequence specificity of homeodomain-DNA interaction

1988 • 501 citations

Structure of the segmentation gene paired and the Drosophila PRD gene set as part of a gene network

1986 • 496 citations

pangolinencodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila

1997 • 494 citations

Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/pbx

1995 • 493 citations

Parasegments and compartments in the Drosophila embryo

1985 • 492 citations

Divergent homeo box proteins recognize similar DNA sequences in Drosophila

1988 • 491 citations

DNA methylation in Drosophila melanogaster

2000 • 482 citations

Dosage-dependent modifiers of polycomb and antennapedia mutations in Drosophila.

1988 • 460 citations

The engrailed locus of drosophila: In situ localization of transcripts reveals compartment-specific expression

1985 • 456 citations

Distribution of the wingless gene product in drosophila embryos: A protein involved in cell-cell communication

1989 • 452 citations

Increasing the Complexity of Coactivation in Nuclear Receptor Signaling

1999 • 449 citations

mof, a putative acetyl transferase gene related to the Tip60 and MOZ human genes and to the SAS genes of yeast, is required for dosage compensation in Drosophila

1997 • 448 citations

A functional interaction between the histone deacetylase Rpd3 and the corepressor Groucho in Drosophila development

1999 • 441 citations

Determination of spatial domains of zygotic gene expression in the Drosophila embryo by the affinity of binding sites for the bicoid morphogen

1989 • 432 citations

A multiple subunit Mi-2 histone deacetylase from Xenopus laevis cofractionates with an associated Snf2 superfamily ATPase

1998 • 426 citations

The making of a fly; The genetics of animal design

1992 • 423 citations

Binding of pumilio to maternal hunchback mRNA is required for posterior patterning in drosophila embryos

1995 • 419 citations

Regulation and function of the Drosophila segmentation gene fushi tarazu

1987 • 415 citations

A group of genes controlling the spatial expression of the bithorax complex in Drosophila

1985 • 413 citations

Ultrastructural patterns of RNA synthesis during early embryogenesis of Drosophila melanogaster

1976 • 409 citations

Structural homology of the product of the Drosophila Krüppel gene with Xenopus transcription factor IIIA

1986 • 406 citations

Control elements of the Drosophila segmentation gene fushi tarazu

1985 • 404 citations

Segmental distribution of bithorax complex proteins during Drosophila development

1985 • 397 citations

Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins.

1995 • 396 citations

Extra specificity from extradenticle: the partnership between HOX and PBX/EXD homeodomain proteins

1996 • 393 citations

Imprinting a determined state into the chromatin of Drosophila

1990 • 391 citations

CYTOGENETIC ANALYSIS OF CHROMOSOME 3 IN DROSOPHILA MELANOGASTER: THE HOMOEOTIC GENE COMPLEX IN POLYTENE CHROMOSOME INTERVAL 84A-B

1980 • 390 citations

Protein-protein interactions: methods for detection and analysis.

1995 • 383 citations

Two-tiered regulation of spatially patterned engrailed gene expression during Drosophila embryogenesis

1988 • 383 citations

Role of segment polarity genes in the definition and maintenance of cell states in the Drosophila embryo

1988 • 381 citations

Isolation, structure, and expression of even-skipped: A second pair-rule gene of Drosophila containing a homeo box

1986 • 380 citations

Progression of the cell cycle through mitosis leads to abortion of nascent transcripts

1991 • 379 citations

The DNA binding specificity of ultrabithorax is modulated by cooperative interactions with extradenticle, another homeoprotein

1994 • 378 citations

Parameters controlling transcriptional activation during early drosophila development

1986 • 377 citations

Chromodomains are protein–RNA interaction modules

2000 • 374 citations

Finger protein of novel structure encoded by hunchback, a second member of the gap class of Drosophila segmentation genes

1987 • 370 citations

Homeotic genes of the bithorax complex repress limb development in the abdomen of the Drosophila embryo through the target gene Distal-less

1992 • 370 citations

Spatial distribution of transcripts from the segmentation gene fushi tarazu during Drosophila embryonic development

1984 • 369 citations

Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling

1998 • 369 citations

Regulation of the Drosophila segmentation gene hunchback by two maternal morphogenetic centres

1988 • 366 citations

Mitotic repression of the transcriptional machinery

1997 • 364 citations

A gene product required for correct initiation of segmental determination in Drosophila

1981 • 361 citations

The Drosophila gene tailless is expressed at the embryonic termini and is a member of the steroid receptor superfamily

1990 • 361 citations

What determines the specificity of action of Drosophila homeodomain proteins?

1990 • 357 citations

Transcriptional regulation of a pair-rule stripe in Drosophila.

1991 • 354 citations

Mechanisms of transcriptional memory

2001 • 354 citations

Synergistic activation and repression of transcription by Drosophila homeobox proteins

1989 • 353 citations

dMi-2, a Hunchback-Interacting Protein That Functions in Polycomb Repression

1998 • 349 citations

The yeast cell-type-specific repressor α2 acts cooperatively with a non-cell-type-specific protein

1988 • 348 citations

A Polycomb response element in the Ubx gene that determines an epigenetically inherited state of repression.

1994 • 346 citations

Isolation of a homoeo box-containing gene from the engrailed region of Drosophila and the spatial distribution of its transcripts

1985 • 346 citations

The WRPW Motif of the Hairy-Related Basic Helix-Loop-Helix Repressor Proteins Acts as a 4-Amino-Acid Transcription Repression and Protein-Protein Interaction Domain

1996 • 344 citations

RNA recognition and translational regulation by a homeodomain protein

1996 • 343 citations

Cell cycle control by the nucleo-cytoplasmic ratio in early Drosophila development

1986 • 338 citations

The abdominal region of the bithorax complex

1985 • 326 citations

The orthodenticle gene encodes a novel homeo domain protein involved in the development of the Drosophila nervous system and ocellar visual structures.

1990 • 326 citations

Analysis of larval segmentation in lethal genotypes associated with the Antennapedia gene complex in Drosophila melanogaster

1981 • 325 citations

Regulation of a Segmentation Stripe by Overlapping Activators and Repressors in the Drosophila Embryo

1991 • 321 citations

Structure of a HoxB1–Pbx1 Heterodimer Bound to DNA

1999 • 318 citations

Chromatin profiling using targeted DNA adenine methyltransferase

2001 • 317 citations

RNA binding and translational suppression by bicoid

1996 • 313 citations

Structure of a DNA-bound Ultrabithorax–Extradenticle homeodomain complex

1999 • 308 citations

Transcription pattern of the Drosophila segmentation gene hairy

1985 • 305 citations

Cyclin Ubiquitination: The destructive end of mitosis

1995 • 304 citations

Distinct molecular mechanism regulate cell cycle timing at successive stages of Drosophila embryogenesis.

1994 • 301 citations

Bcl-2 and Bax interactions in mitochondria probed with green fluorescent protein and fluorescence resonance energy transfer

1998 • 301 citations

The Drosophila segmentation gene runt encodes a novel nuclear regulatory protein that is also expressed in the developing nervous system.

1990 • 299 citations

Roles of wingless in patterning the larval epidermis of Drosophila

1991 • 295 citations

Control of Drosophila body pattern by the hunchback morphogen gradient

1992 • 294 citations

Multiple steps in the localization of bicoid RNA to the anterior pole of the Drosophila oocyte

1989 • 291 citations

Autoradiographic study of protein and RNA formation during early development of Drosophila eggs

1976 • 290 citations

Exit from mitosis is regulated by Drosophila fizzy and the sequential destruction of cyclins A, B and B3.

1995 • 286 citations

Molecular analysis of the armadillo locus: uniformly distributed transcripts and a protein with novel internal repeats are associated with a Drosophila segment polarity gene.

1989 • 284 citations

Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling

1997 • 283 citations

Genomic and cDNA clones of the homeotic locus Antennapedia in Drosophila.

1983 • 282 citations

Expression of the caudal gene in the germ line of Drosophila: Formation of an RNA and protein gradient during early embryogenesis

1987 • 282 citations

Complementary patterns of even-skipped and fushi tarazu expression involve their differential regulation by a common set of segmentation genes in Drosophila.

1987 • 276 citations

Pbx Modulation of Hox Homeodomain Amino-Terminal Arms Establishes Different DNA-Binding Specificities across theHoxLocus

1996 • 274 citations

Early and late periodic patterns of even skipped expression are controlled by distinct regulatory elements that respond to different spatial cues

1989 • 273 citations

Mediation of Drosophila head development by gap-like segmentation genes

1990 • 271 citations

extradenticle Raises the DNA binding specificity of homeotic selector gene products

1994 • 269 citations

The Drosophila Polycomb Group proteins ESC and E(Z) are present in a complex containing the histone-binding protein p55 and the histone deacetylase RPD3

2001 • 269 citations

The location of Ultrabithorax transcripts in Drosophila tissue sections.

1983 • 265 citations

The orthodenticle gene is regulated by bicoid and torso and specifies Drosophila head development

1990 • 264 citations

The third-chromosome group of mutant characters of Drosophila melanogaster

1923 • 261 citations

A morphogenetic gradient of hunchback protein organizes the expression of the gap genes Krüppel and knirps in the early Drosophila embryo

1990 • 258 citations

DNA-replication checkpoint control at the Drosophila midblastula transition

1997 • 258 citations

Expression and embryonic function of empty spiracles: a Drosophila homeo box gene with two patterning functions on the anterior-posterior axis of the embryo.

1989 • 257 citations

Interaction of Short-Range Repressors with Drosophila CtBP in the Embryo

1998 • 256 citations

Regulation of the Ultrabithorax gene of drosophila by other bithorax complex genes

1985 • 255 citations

Autoregulatory and gap gene response elements of the even-skipped promoter of Drosophila.

1989 • 254 citations

Groucho-Dependent and -Independent Repression Activities of Runt Domain Proteins

1997 • 253 citations

Multiple modes of engrailed regulation in the progression towards cell fate determination

1991 • 248 citations

Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila.

1990 • 246 citations

Regulation of Antennapedia transcript distribution by the bithorax complex in Drosophila

1984 • 244 citations

Analysis of an even-skipped rescue transgene reveals both composite and discrete neuronal and early blastoderm enhancers, and multi-stripe positioning by gap gene repressor gradients*

1999 • 243 citations

Regulation of Two Pair-Rule Stripes by a Single Enhancer in theDrosophilaEmbryo

1996 • 243 citations

Spatially Regulated Expression of Homeotic Genes in Drosophila

1985 • 242 citations

Zygotically active genes that affect the spatial expression of the fushi tarazu segmentation gene during early Drosophila embryogenesis

1986 • 242 citations

Regulatory interactions between the segmentation genes fushi tarazu, hairy, and engrailed in the Drosophila blastoderm

1986 • 242 citations

Transcriptional repression by the Drosophila even-skipped protein: definition of a minimal repression domain.

1993 • 241 citations

Drosophila CtBP: a Hairy-interacting protein required for embryonic segmentation and Hairy-mediated transcriptional repression

1998 • 240 citations

Groucho acts as a corepressor for a subset of negative regulators, including Hairy and Engrailed

1997 • 240 citations

Epigenetic Inheritance of Active Chromatin After Removal of the Main Transactivator

1999 • 239 citations

Isolation of caudal , a Drosophila homeo box-containing gene with maternal expression, whose transcripts form a concentration gradient at the pre-blastoderm stage

1985 • 238 citations

The distribution of Ultrabithorax transcripts in Drosophila embryos

1985 • 237 citations

The Drosophila sloppy paired locus encodes two proteins involved in segmentation that show homology to mammalian transcription factors.

1992 • 233 citations

Synergy between the hunchback and bicoid morphogens is required for anterior patterning in Drosophila

1994 • 232 citations

A homoeotic mutation transforming leg to antenna in Drosophila

1981 • 232 citations

Borders of parasegments in Drosophila embryos are delimited by the fushi tarazu and even-skipped genes

1987 • 230 citations

Autoregulation of a drosophila homeotic selector gene

1988 • 229 citations

The eve stripe 2 enhancer employs multiple modes of transcriptional synergy

1996 • 227 citations

Cooperative Interactions between HOX and PBX Proteins Mediated by a Conserved Peptide Motif

1995 • 224 citations

Establishment and refinement of segmental pattern in the Drosophila embryo: spatial control of engrailed expression by pair-rule genes.

1987 • 220 citations

a1 Protein alters the dna binding specificity of α2 repressor

1988 • 218 citations

Abdominal segmentation of the Drosophila embryo requires a hormone receptor-like protein encoded by the gap gene knirps

1988 • 217 citations

The Developmental and Molecular Biology of Genes that Subdivide the Body of Drosophila

2000 • 216 citations

Two Gap Genes Mediate Maternal Terminal Pattern Information in Drosophila

1990 • 214 citations

Structure of two genes at the gooseberry locus related to the paired gene and their spatial expression during Drosophila embryogenesis.

1987 • 213 citations

Multiple functions of segment polarity genes in Drosophila

1987 • 212 citations

dCtBP mediates transcriptional repression by Knirps, Krüppel and Snail in the Drosophila embryo

1998 • 212 citations

Developmental and molecular analysis of Deformed ; a homeotic gene controlling Drosophila head development

1987 • 210 citations

Cell-free system for assembly of transcriptionally repressed chromatin from Drosophila embryos.

1992 • 210 citations

Localized and Transient Transcription of Hox Genes Suggests a Link between Patterning and the Segmentation Clock

2001 • 210 citations

Chip, a widely expressed chromosomal protein required for segmentation and activity of a remote wing margin enhancer in Drosophila

1997 • 208 citations

The degree of variation in DNA sequence recognition among four Drosophila homeotic proteins.

1994 • 207 citations

Repression of ci-D in posterior compartments of Drosophila by engrailed.

1990 • 205 citations

PEBP2 alpha B/mouse AML1 consists of multiple isoforms that possess differential transactivation potentials.

1994 • 204 citations

Trithorax and dCBP Acting in a Complex to Maintain Expression of a Homeotic Gene

2001 • 202 citations

The correct activation of Antennapedia and bithorax complex genes requires the fushi tarazu gene

1986 • 201 citations

Mitotic regulation of TFIID: inhibition of activator-dependent transcription and changes in subcellular localization.

1996 • 200 citations

C-Terminal Binding Protein Is a Transcriptional Repressor That Interacts with a Specific Class of Vertebrate Polycomb Proteins

1999 • 196 citations

A gap gene, hunchback, regulates the spatial expression of Ultrabithorax

1986 • 195 citations

Genome-Wide Protein Interaction Screens Reveal Functional Networks Involving Sm-Like Proteins

2000 • 194 citations

Regulation of segment polarity genes in the Drosophila blastoderm by fushi tarazu and even skipped

1988 • 194 citations

The nuclear hormone receptor Ftz-F1 is a cofactor for the Drosophila homeodomain protein Ftz

1997 • 193 citations

Spatial distribution of Antennapedia transcripts during Drosophila development.

1983 • 191 citations

Distant liaisons: long-range enhancer–promoter interactions in Drosophila

1999 • 190 citations

The bithorax complex: control of segmental identity

1987 • 188 citations

Novel transcripts from the Ultrabithorax domain of the bithorax complex.

1987 • 188 citations

The nuclear receptor homologue Ftz-F1 and the homeodomain protein Ftz are mutually dependent cofactors

1997 • 188 citations

The localization and regulation of Antennapedia protein expression in Drosophila embryos

1986 • 186 citations

dMi-2 and ISWI chromatin remodelling factors have distinct nucleosome binding and mobilization properties

2000 • 186 citations

Cross-Regulatory Interactions Among Pair-Rule Genes in Drosophila

1986 • 184 citations

The Drosophila ATM homologue Mei-41 has an essential checkpoint function at the midblastula transition

1999 • 184 citations

Accumulation of collagen III at the cleft points of developing mouse submandibular epithelium

1988 • 181 citations

Cooperative DNA-binding by Bicoid provides a mechanism for threshold-dependent gene activation in the Drosophila embryo

1998 • 180 citations

Domain of Ultrabithorax expression in Drosophila visceral mesoderm from autoregulation and exclusion

1988 • 178 citations

The control of trunk Hox specificity and activity by Extradenticle

1999 • 178 citations

Transcriptional repression in development

1996 • 176 citations

Spatial and temporal patterns of Krüppel gene expression in early Drosophila embryos

1985 • 175 citations

Activation of transcription in Drosophila embryos is a gradual process mediated by the nucleocytoplasmic ratio.

1996 • 174 citations

The high mobility group protein HMG1 can reversibly inhibit class II gene transcription by interaction with the TATA-binding protein.

1994 • 174 citations

The Nanos gradient in Drosophila embryos is generated by translational regulation.

1996 • 171 citations

Isolation of the paired gene of Drosophila and its spatial expression during early embryogenesis

1986 • 171 citations

Rates of synthesis of major classes of RNA in Drosophila embryos

1979 • 168 citations

Cross-regulatory interactions among the gap genes of Drosophila

1986 • 168 citations

The Pentapeptide Motif of Hox Proteins Is Required for Cooperative DNA Binding with Pbx1, Physically Contacts Pbx1, and Enhances DNA Binding by Pbx1

1995 • 167 citations

A Drosophila homologue of human Sp1 is a head-specific segmentation gene

1993 • 166 citations

The bx region enhancer, a distant cis-control element of the Drosophila Ubx gene and its regulation by hunchback and other segmentation genes.

1991 • 166 citations

Concentration-dependent transcriptional activation or repression by Krüppel from a single binding site

1991 • 166 citations

GENETIC ANALYSIS OF THE ANTENNAPEDIA GENE COMPLEX (ANT-C) AND ADJACENT CHROMOSOMAL REGIONS OF DROSOPHILA MELANOGASTER. I. POLYTENE CHROMOSOME SEGMENTS 84B-D

1980 • 165 citations

odd-paired: a zinc finger pair-rule protein required for the timely activation of engrailed and wingless in Drosophila embryos.

1994 • 165 citations

A New Transcription Factor Family Associated with Human Leukemias

1995 • 164 citations

Zygotic degradation of two maternal Cdc25 mRNAs terminates Drosophila's early cell cycle program.

1996 • 163 citations

Long range repression conferring boundaries of Ultrabithorax expression in the Drosophila embryo.

1991 • 162 citations

Mutually repressive interactions between the gap genes giant and Krüppel define middle body regions of the Drosophila embryo

1991 • 159 citations

Short-range repression permits multiple enhancers to function autonomously within a complex promoter.

1994 • 159 citations

Empty spiracles, a gap gene containing a homeobox involved in Drosophila head development.

1992 • 156 citations

Spatial regulation of the Antennapedia and Ultrabithorax homeotic genes during Drosophila early development.

1989 • 154 citations

Gap genes define the limits of antennapedia and bithorax gene expression during early development in Drosophila.

1988 • 151 citations

Loss of gene function through rapid mitotic cycles in the Drosophila embryo

1992 • 150 citations

Concentration-dependent activities of the even-skipped protein in Drosophila embryos.

1992 • 149 citations

Patterns of engrailed and fushi tarazu transcripts reveal novel intermediate stages in Drosophila segmentation

1985 • 148 citations

Net, a negative Ras-switchable TCF, contains a second inhibition domain, the CID, that mediates repression through interactions with CtBP and de-acetylation

1999 • 146 citations

Materials for the study of variation treated with especial regard to discontinuity in the origin of species

1894 • 146 citations

Both Pbx1 and E2A-Pbx1 Bind the DNA Motif ATCAATCAA Cooperatively with the Products of Multiple Murine Hox Genes, Some of Which Are Themselves Oncogenes

1995 • 146 citations

A model for extradenticle function as a switch that changes HOX proteins from repressors to activators

1997 • 145 citations

A purified Drosophila homeodomain protein represses transcription in vitro

1989 • 142 citations

Localized expression of sloppy paired protein maintains the polarity of Drosophila parasegments.

1994 • 139 citations

Short-range transcriptional repressors mediate both quenching and direct repression within complex loci in Drosophila.

1996 • 138 citations

HMG-D, the Drosophila melanogaster homologue of HMG 1 protein, is associated with early embryonic chromatin in the absence of histone H1.

1994 • 138 citations

Gradients of Krüppel and knirps gene products direct pair-rule gene stripe patterning in the posterior region of the drosophila embryo

1990 • 137 citations

Control and function of terminal gap gene activity in the posterior pole region of the Drosophila embryo

1991 • 137 citations

Regulation of runt transcription by Drosophila segmentation genes

1993 • 136 citations

Chromatin fractionation procedure that yields nucleosomes containing near-stoichiometric amounts of high mobility group nonhistone chromosomal proteins

1979 • 136 citations

Isolation of the Drosophila segmentation gene runt and analysis of its expression during embryogenesis.

1988 • 135 citations

Recessive lethal mutations within the bithorax-complex in Drosophila

1985 • 135 citations

Cloning and transcriptional analysis of the segmentation gene fushi tarazu of Drosophila

1984 • 135 citations

Isolation, structure, and expression of labial, a homeotic gene of the Antennapedia Complex involved in Drosophila head development.

1989 • 132 citations

Binding of yeast al and α2 as a heterodimer to the operator DNA of a haploid-specific gene

1990 • 132 citations

Regulation of segmentation and segmental identity byDrosophilahomeoproteins: the role of DNA binding in functional activity and specificity

1997 • 130 citations

Post-replicative nonribosomal transcription units in D. melanogaster embryos

1979 • 129 citations

Yeast repressor alpha 2 binds to its operator cooperatively with yeast protein Mcm1.

1989 • 125 citations

Molecular characterization of the male-specific lethal-3 gene and investigations of the regulation of dosage compensation in Drosophila

1995 • 125 citations

The proboscipedia locus of the Antennapedia complex: a molecular and genetic analysis.

1988 • 125 citations

Pole region-dependent repression of the Drosophila gap gene Krüppel by maternal gene products

1987 • 124 citations

The Drosophila morphogenetic protein Bicoid binds DNA cooperatively

1996 • 124 citations

trithorax regulates multiple homeotic genes in the bithorax and Antennapedia complexes and exerts different tissue-specific, parasegment-specific and promoter-specific effects on each

1993 • 119 citations

Discrete Polycomb-binding sites in each parasegmental domain of the bithorax complex

1995 • 119 citations

A genetic and developmental analysis of mutations in the Deformed locus in Drosophila melanogaster

1987 • 117 citations

Individual stripe regulatory elements in the Drosophila hairy promoter respond to maternal, gap, and pair-rule genes.

1991 • 117 citations

The origin and evolution of segmentation

1999 • 116 citations

Expression, modification, and localization of the fushi tarazu protein in Drosophila embryos.

1988 • 116 citations

The Rpd3 histone deacetylase is required for segmentation of the Drosophila embryo

1999 • 115 citations

Control of development and immunity by Rel transcription factors in Drosophila

1999 • 115 citations

Role of Oocyte Position in Establishment of Anterior-Posterior Polarity in Drosophila

1994 • 115 citations

Increase in nuclear poly(A)-containing RNA at syncytial blastoderm in Drosophila melanogaster embryos

1976 • 114 citations

Hox Homeodomain Proteins Exhibit Selective Complex Stabilities with Pbx and DNA

1996 • 114 citations

Pattern formation in the Drosophila embryo: allocation of cells to parasegments by even-skipped and fushi tarazu

1989 • 113 citations

Two homeo domain proteins bind with similar specificity to a wide range of DNA sites in Drosophila embryos.

1994 • 112 citations

The giant gene of Drosophila encodes a b-ZIP DNA-binding protein that regulates the expression of other segmentation gap genes

1992 • 112 citations

Dual Role of the Drosophila Pattern Gene tailless in Embryonic Termini

1991 • 111 citations

Localization of transcripts from the wingless gene in whole Drosophila embryos

1988 • 111 citations

Correlative changes in homoeotic and segmentation gene expression in Krüppel mutant embryos of Drosophila

1986 • 111 citations

Compartments in Animal Development

1979 • 110 citations

Structural Determinants within Pbx1 That Mediate Cooperative DNA Binding with Pentapeptide-Containing Hox Proteins: Proposal for a Model of a Pbx1-Hox-DNA Complex

1996 • 110 citations

A structural model for a homeotic protein-extradenticle-DNA complex accounts for the choice of HOX protein in the heterodimer.

1996 • 108 citations

The molecular mechanism of mitotic inhibition of TFIIH is mediated by phosphorylation of CDK7

1998 • 106 citations

GENETIC ANALYSIS OF THE ANTENNAPEDIA GENE COMPLEX (ANT-C) AND ADJACENT CHROMOSOMAL REGIONS OF DROSOPHILA MELANOGASTER. II. POLYTENE CHROMOSOME SEGMENTS 84A–84B1,2

1980 • 106 citations

Dimerization and the control of transcription by Krüppel

1993 • 106 citations

Molecular structure and spatial expression of a homeobox gene from the labial region of the Antennapedia-complex.

1988 • 104 citations

The hexapeptide LFPWMR in Hoxb-8 is required for cooperative DNA binding with Pbx1 and Pbx2 proteins.

1995 • 104 citations

hairy mediates dominant repression in the Drosophila embryo

1997 • 103 citations

The carboxy‐terminal region of adenovirus E1A activates transcription through targeting of a C‐terminal binding protein‐histone deacetylase complex

1998 • 103 citations

Switching the in vivo specificity of a minimal Hox-responsive element

1997 • 102 citations

Changing rates of histone mRNA synthesis and turnover in Drosophila embryos

1980 • 101 citations

Molecular analysis of odd-skipped, a zinc finger encoding segmentation gene with a novel pair-rule expression pattern.

1990 • 100 citations

The spatial and temporal deployment ofDfdandScrtranscripts throughout development ofDrosophila

1987 • 99 citations

Pinning Down Positional Information

1998 • 99 citations

Early even-skipped stripes act as morphogenetic gradients at the single cell level to establish engrailed expression

1995 • 98 citations

Functional Dissection of the α and β Subunits of Transcription Factor PEBP2 and the Redox Susceptibility of Its DNA Binding Activity

1996 • 97 citations

Drosophila proteins related to vertebrate DNA (5-cytosine) methyltransferases

1999 • 97 citations

A molecular analysis of fushi tarazu, a gene in Drosophila melanogaster that encodes a product affecting embryonic segment number and cell fate

1984 • 96 citations

A novel spatial transcription pattern associated with the segmentation gene, giant, of Drosophila.

1989 • 96 citations

Homeodomain-independent activity of the fushi tarazu polypeptide in Drosophila embryos

1992 • 96 citations

Sharp anterior boundary of homeotic gene expression conferred by the fushi tarazu protein.

1992 • 95 citations

Temporal and spatial distribution of transcripts from the Deformed gene of Drosophila

1987 • 94 citations

The gap protein knirps mediates both quenching and direct repression in the Drosophila embryo.

1996 • 94 citations

Groucho and dCtBP mediate separate pathways of transcriptional repression in the Drosophila embryo

1999 • 93 citations

Region-specific alleles of the Drosophila segmentation gene hairy.

1988 • 91 citations

Chromosomal proteins of Drosophila embryos

1973 • 91 citations

Drosophila Homologs of the Proto-Oncogene Product PEBP2/CBFβ Regulate the DNA-Binding Properties of Runt

1996 • 91 citations

Long-range repression in the Drosophila embryo.

1996 • 90 citations

Disperse versus Compact Elements for the Regulation ofruntStripes inDrosophila

1996 • 89 citations

DNA Template and Activator-Coactivator Requirements for Transcriptional Synergism by Drosophila Bicoid

1995 • 89 citations

Patterning of the Drosophila embryo by a homeodomain-deleted Ftz polypeptide

1996 • 88 citations

Ectopic expression of UBX and ABD-B proteins during Drosophila embryogenesis: competition, not a functional hierarchy, explains phenotypic suppression

1992 • 87 citations

Activity regulation of a Hox protein and a role for the homeodomain in inhibiting transcriptional activation

1999 • 87 citations

Repression of TFIIH Transcriptional Activity and TFIIH-Associated cdk7 Kinase Activity at Mitosis

1998 • 87 citations

Hox gene products modulate the DNA binding activity of Pbx1 and Pbx2

1995 • 87 citations

Autonomous concentration-dependent activation and repression of Krüppel by hunchback in the Drosophila embryo

1994 • 87 citations

Cloning of the homeotic Sex combs reduced gene in Drosophila and in situ localization of its transcripts

1985 • 87 citations

Induction of labial expression in the Drosophila endoderm: response elements for dpp signalling and for autoregulation

1992 • 87 citations

Decoding positional information: regulation of the pair-rule gene hairy

1990 • 86 citations

Targeting gene expression to the head: the Drosophila orthodenticle gene is a direct target of the Bicoid morphogen

1998 • 86 citations

Mutations affecting the stability of the fushi tarazu protein of Drosophila.

1990 • 85 citations

A cluster of Drosophila homeobox genes involved in mesoderm differentiation programs

2001 • 85 citations

Control of expression of the homeotic labial (lab) locus of Drosophila melanogaster. evidence for both positive and negative autogenous regulation

1991 • 84 citations

Complex regulation of early paired expression: initial activation by gap genes and pattern modulation by pair-rule genes

1993 • 84 citations

A comparison of invivo and invitro DNA-binding specificities suggests a new model for homeoprotein DNA binding in Drosophila embryos

1999 • 84 citations

Chip interacts with diverse homeodomain proteins and potentiates Bicoid activity in vivo

2000 • 84 citations

Functional redundancy: the respective roles of the two sloppy paired genes in Drosophila segmentation.

1994 • 82 citations

Mechanisms of transcriptional regulation by Runt domain proteins

2000 • 81 citations

Autocatalytic ftz activation and metameric instability induced by ectopic ftz expression

1989 • 80 citations

Eve and ftz regulate a wide array of genes in blastoderm embryos: the selector homeoproteins directly or indirectly regulate most genes inDrosophila

1998 • 79 citations

Concentration-dependent patterning by an ectopic expression domain of the Drosophila gap gene knirps

1997 • 79 citations

Differential regulation of transcription preinitiation complex assembly by activator and repressor homeo domain proteins.

1992 • 78 citations

Genes Regulating the Remote Wing Margin Enhancer in the Drosophila cut Locus

1996 • 78 citations

The Antennapedia gene is required and expressed in parasegments 4 and 5 of the Drosophila embryo

1986 • 77 citations

A high-mobility-group protein and its cDNAs from Drosophila melanogaster.

1992 • 76 citations

Interactions between the pair-rule genes runt, hairy, even-skipped and fushi tarazu and the establishment of periodic pattern in the Drosophila embryo

1988 • 75 citations

Multiple functions of a Drosophila homeotic gene, zeste-white 3, during segmentation and neurogenesis

1989 • 74 citations

Repression of RNA Polymerase II and III Transcription during M Phase of the Cell Cycle

1996 • 74 citations

Specific DNA recognition and intersite spacing are critical for action of the bicoid morphogen.

1994 • 74 citations

A clonal analysis of the requirement for the trithorax gene in the diversification of segments in Drosophila

1985 • 72 citations

Gene Activity in Early Development.

1970 • 71 citations

Changing rates of DNA and RNA synthesis in Drosophila embryos

1981 • 71 citations

A universal target sequence is bound in vitro by diverse homeodomains

1993 • 71 citations

Analysis of maternal effect mutant combinations elucidates regulation and function of the overlap of hunchback and Krüppel gene expression in the Drosophila blastoderm embryo

1989 • 68 citations

Two distinct mechanisms for differential positioning of gene expression borders involving the Drosophila gap protein giant

1998 • 68 citations

Control of segmental asymmetry in Drosophila embryos

1993 • 68 citations

Spatial control of hairy protein expression during embryogenesis

1989 • 67 citations

Drosophila wee1 Has an Essential Role in the Nuclear Divisions of Early Embryogenesis

2000 • 65 citations

Transcriptional repression by theDrosophilaGiant protein:ciselement positioning provides an alternative means of interpreting an effector gradient

1999 • 65 citations

Pair—rule segmentation genes regulate the expression of the homeotic selector gene, Deformed

1988 • 65 citations

Thoracic Patterning by the Drosophila Gap Gene hunchback

2001 • 62 citations

Target sequences for hunchback in a control region conferring Ultrabithorax expression boundaries

1991 • 61 citations

Mechanism and Bicoid-dependent control of hairy stripe 7expression in the posterior region of the Drosophila embryo

1997 • 60 citations

FTZ-Factor1 and Fushi tarazu interact via conserved nuclear receptor and coactivator motifs

2001 • 58 citations

Establishing Parasegments in Drosophila Embryos: Roles of the odd-skipped and naked Genes

1995 • 58 citations

Molecular and Genetic Analysis of the hairy Locus in Drosophila

1985 • 57 citations

Evolution of segmentation genes in insects

1995 • 56 citations

Non-periodic cues generate seven ftz stripes in the Drosophila embryo

1995 • 56 citations

Huckebein repressor activity in Drosophila terminal patterning is mediated by Groucho

1999 • 56 citations

The zygotic control of Drosophila pair-rule gene expression: II. Spatial repression by gap and pair-rule gene products

1989 • 55 citations

The even-skipped Locus Is Contained in a 16-kb Chromatin Domain

1999 • 53 citations

Developmentally regulated nuclear transport of transcription factors in Drosophila embryos enable the heat shock response

1998 • 50 citations

dCtBP-Dependent and -Independent Repression Activities of the Drosophila Knirps Protein

2000 • 49 citations

Functional dissection of the paired segmentation gene in Drosophila embryos.

1991 • 49 citations

A synthetic homeodomain binding site acts as a cell type specific, promoter specific enhancer in Drosophila embryos.

1990 • 48 citations

Dynamic changes in the functions of Odd-skipped during early Drosophila embryogenesis

1998 • 47 citations

Groucho augments the repression of multiple Even skipped target genes in establishing parasegment boundaries

2001 • 47 citations

Positioning adjacent pair-rule stripes in the posterior Drosophila embryo

1994 • 46 citations

DNA binding specificity of two homeodomain proteins in vitro and in Drosophila embryos.

1996 • 46 citations

Differential interactions between Brother proteins and Runt domain proteins in the Drosophila embryo and eye

1999 • 45 citations

CtBP-dependent activities of the short-range Giant repressor in the Drosophila embryo

2001 • 41 citations

Pair-rule expression of the Drosophila fushi tarazu gene: a nuclear receptor response element mediates the opposing regulatory effects of runt and hairy

1995 • 40 citations

Kinetic analysis of segmentation gene interactions in Drosophila embryos

1999 • 39 citations

Conservation of regulatory elements controlling hairy pair-rule stripe formation

1993 • 39 citations

The making of a fly: The genetics of animal design

1992 • 38 citations

Identification of candidate downstream genes for the homeodomain transcription factor Labial in Drosophila through oligonucleotide-array transcript imaging.

2001 • 38 citations

Local action of long-range repressors in the Drosophila embryo

2001 • 35 citations

Role of Gap Genes in Early Drosophila Development

1990 • 34 citations

The transcription unit of the Drosophila engrailed locus: an unusually small portion of a 70,000 bp gene.

1987 • 33 citations

Segmentation gene product Fushi tarazu is an LXXLL motif-dependent coactivator for orphan receptor FTZ-F1

2001 • 33 citations

Isolation of Mutations that Disrupt Cooperative DNA Binding by the Drosophila Bicoid Protein

2001 • 32 citations

fushi tarazu protein expression in the cellular blastoderm of Drosophila detected using a novel imaging technique

1989 • 31 citations

Redundant function of Runt Domain binding partners, Big brother and Brother, duringDrosophiladevelopment

2001 • 31 citations

Cloning sequences from the hairy gene of Drosophila.

1984 • 31 citations

Establishment and maintenance of parasegmental compartments

2001 • 31 citations

Chromosomal binding sites of Ultrabithorax homeotic proteins

1996 • 30 citations

Activation of posterior pair-rule stripe expression in response to maternal caudal and zygotic knirps activities

1998 • 30 citations

Sequences Outside the Homeodomain of Bicoid Are Required for Protein-Protein Interaction

1996 • 30 citations

Transcriptional repression in theDrosophilaembryo

1995 • 29 citations

Dissection of the Torso signal transduction pathway in Drosophila

1995 • 27 citations

A two-step mode of stripe formation in the Drosophila blastoderm requires interactions among primary pair rule genes

1994 • 27 citations

Trans-regulatory functions in the Abdominal-B gene of the bithorax complex

1987 • 26 citations

The influence on the blastoderm fate map of maternal-effect genes that affect the antero-posterior pattern in Drosophila

1987 • 23 citations

Mechanisms regulating target gene selection by the homeodomain-containing protein Fushi tarazu

2000 • 22 citations

Genetic Characterization of the Homeodomain-Independent Activity of the Drosophila fushi taruzu Gene Product

1996 • 21 citations

Recognition of Multiple Patterns of DNA Sites by Drosophila Homeodomain Protein Bicoid

1999 • 21 citations

Drosophila hairy pair-rule gene regulates embryonic patterning outside its apparent stripe domains

1993 • 19 citations

Gene regulation in theDrosophilaembryo

1996 • 18 citations

Mitotic delay dependent survival identifies components of cell cycle control in the Drosophila blastoderm

1995 • 17 citations

Runt domain partner proteins enhance DNA binding and transcriptional repression in cultured Drosophila cells

1996 • 8 citations

Regulation of Dorso/Ventral Patterning in the Drosophila Embryo by Multiple Dorsal-interacting Proteins

2000 • 7 citations