Groucho-Dependent and -Independent Repression Activities of Runt Domain Proteins

A novel genetic system to detect protein–protein interactions

1989 • 6,022 citations

AML1, the Target of Multiple Chromosomal Translocations in Human Leukemia, Is Essential for Normal Fetal Liver Hematopoiesis

1996 • 1,885 citations

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis.

1996 • 1,195 citations

t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1.

1991 • 897 citations

The CBFβ Subunit Is Essential for CBFα2 (AML1) Function In Vivo

1996 • 630 citations

Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins

1994 • 560 citations

Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions.

1995 • 546 citations

AML1, AML2, and AML3, the Human Members of the runt domain Gene-Family: cDNA Structure, Expression, and Chromosomal Localization

1994 • 403 citations

Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta.

1996 • 382 citations

The WRPW Motif of the Hairy-Related Basic Helix-Loop-Helix Repressor Proteins Acts as a 4-Amino-Acid Transcription Repression and Protein-Protein Interaction Domain

1996 • 344 citations

The runt domain identifies a new family of heterometric transcriptional regulators

1993 • 331 citations

The Drosophila segmentation gene runt encodes a novel nuclear regulatory protein that is also expressed in the developing nervous system.

1990 • 299 citations

ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function.

1997 • 286 citations

Cooperative binding of Ets-1 and core binding factor to DNA.

1994 • 216 citations

Purification of core-binding factor, a protein that binds the conserved core site in murine leukemia virus enhancers.

1992 • 194 citations

Detection of DNA rearrangements in the AML1 and ETO loci and of an AML1/ETO fusion mRNA in patients with t(8;21) acute myeloid leukemia

1993 • 193 citations

Patterning of cells in the Drosophila eye by Lozenge, which shares homologous domains with AML1.

1996 • 187 citations

Positive and negative regulation of granulocyte-macrophage colony- stimulating factor promoter activity by AML1-related transcription factor, PEBP2

1995 • 165 citations

A New Transcription Factor Family Associated with Human Leukemias

1995 • 164 citations

Molecular Interaction between TLE1 and the Carboxyl-Terminal Domain of HES-1 Containing the WRPW Motif

1996 • 154 citations

Transactivation of the Moloney murine leukemia virus and T-cell receptor beta-chain enhancers by cbf and ets requires intact binding sites for both proteins

1995 • 153 citations

deadpan, an essential pan-neural gene encoding an HLH protein, acts as a denominator in Drosophila sex determination

1992 • 142 citations

The Drosophila segmentation gene runt acts as a position-specific numerator element necessary for the uniform expression of the sex-determining gene Sex-lethal.

1991 • 139 citations

Two genetically and molecularly distinct functions involved in early neurogenesis reside within the Enhancer of split locus of Drosophila melanogaster.

1991 • 128 citations

c-Myb and Core-Binding Factor/PEBP2 Display Functional Synergy but Bind Independently to Adjacent Sites in the T-Cell Receptor δ Enhancer

1995 • 115 citations

Functional domains of the t(8;21) fusion protein, AML-1/ETO.

1995 • 113 citations

Expression and function of the Drosophila gene runt in early stages of neural development

1991 • 102 citations

Drosophila Homologs of the Proto-Oncogene Product PEBP2/CBFβ Regulate the DNA-Binding Properties of Runt

1996 • 91 citations

Dosage requirements for runt in the segmentation of Drosophila embryos

1986 • 91 citations

Gap gene properties of the pair-rule gene runt during Drosophila segmentation

1994 • 76 citations

Control of segmental asymmetry in Drosophila embryos

1993 • 68 citations

Molecules making waves in axon guidance.

1997 • 67 citations

SpRunt-1, a New Member of the Runt Domain Family of Transcription Factors, Is a Positive Regulator of the Aboral Ectoderm-SpecificCyIIIAGene in Sea Urchin Embryos

1996 • 62 citations

Overexpression of the AML1 proto-oncoprotein in NIH3T3 cells leads to neoplastic transformation depending on the DNA-binding and transactivational potencies.

1996 • 62 citations

In vivo interactions of the Drosophila Hairy and Runt transcriptional repressors with target promoters.

1996 • 47 citations

Pair-rule expression of the Drosophila fushi tarazu gene: a nuclear receptor response element mediates the opposing regulatory effects of runt and hairy

1995 • 40 citations

Transcriptional regulation of theSex-lethalgene by helix-loop-helix proteins

1995 • 27 citations

A two-step mode of stripe formation in the Drosophila blastoderm requires interactions among primary pair rule genes

1994 • 27 citations

Conservation and function of the transcriptional regulatory protein Runt.

1995 • 25 citations