Regulation of Dorso/Ventral Patterning in the Drosophila Embryo by Multiple Dorsal-interacting Proteins

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

1997 • 5,522 citations

The ancient regulatory-protein family of WD-repeat proteins

1994 • 1,478 citations

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.

1995 • 1,296 citations

Identification and Characterization of an IκB Kinase

1997 • 1,166 citations

The structure of the G protein heterotrimer Giα1β1γ2

1995 • 1,091 citations

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

1994 • 1,012 citations

Activation of Raf as a Result of Recruitment to the Plasma Membrane

1994 • 979 citations

A CONSERVED SIGNALING PATHWAY: The Drosophila Toll-Dorsal Pathway

1996 • 822 citations

Crystal structure of a GA protein βγdimer at 2.1 Å resolution

1996 • 741 citations

I kappa B interacts with the nuclear localization sequences of the subunits of NF-kappa B: a mechanism for cytoplasmic retention.

1992 • 731 citations

Regulation of NF-κB by Cyclin-Dependent Kinases Associated with the p300 Coactivator

1997 • 725 citations

A gradient of nuclear localization of the dorsal protein determines dorsoventral pattern in the Drosophila embryo

1989 • 652 citations

The Crystal Structure of the IκBα/NF-κB Complex Reveals Mechanisms of NF-κB Inactivation

1998 • 563 citations

The histone tails of the nucleosome

1998 • 512 citations

Hundreds of ankyrin‐like repeats in functionally diverse proteins: Mobile modules that cross phyla horizontally?

1993 • 504 citations

Dorsal , an Embryonic Polarity Gene in Drosophila , Is Homologous to the Vertebrate Proto-Oncogene, c- rel

1987 • 485 citations

The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila

1989 • 472 citations

Repression domain of the yeast global repressor Tup1 interacts directly with histones H3 and H4.

1996 • 460 citations

A functional interaction between the histone deacetylase Rpd3 and the corepressor Groucho in Drosophila development

1999 • 441 citations

Relocalization of the dorsal protein from the cytoplasm to the nucleus correlates with its function

1989 • 431 citations

Conjunction dysfunction: CBP/p300 in human disease

1998 • 406 citations

Intramolecular masking of the nuclear location signal and dimerization domain in the precursor for the p50 NF-κB subunit

1992 • 399 citations

SIGNALING PATHWAYS THAT ESTABLISH THE DORSAL-VENTRAL PATTERN OF THE DROSOPHILA EMBRYO

1995 • 348 citations

Information for the dorsal–ventral pattern of the Drosophila embryo is stored as maternal mRNA

1984 • 335 citations

TAFs mediate transcriptional activation and promoter selectivity

1996 • 334 citations

Transport into and out of the cell nucleus

1998 • 332 citations

The dorsal gradient morphogen regulates stripes of rhomboid expression in the presumptive neuroectoderm of the Drosophila embryo.

1992 • 324 citations

Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo.

1991 • 324 citations

dorsal-twist interactions establish snail expression in the presumptive mesoderm of the Drosophila embryo.

1992 • 309 citations

Groucho proteins: transcriptional corepressors for specific subsets of DNA-binding transcription factors in vertebrates and invertebrates

1998 • 299 citations

The control of cell fate along the dorsal-ventral axis of the Drosophila embryo

1991 • 246 citations

cactus, a gene involved in dorsoventral pattern formation of Drosophila, is related to the IκB gene family of vertebrates

1992 • 243 citations

Establishment of the Mesoderm-Neuroectoderm Boundary in the Drosophila Embryo

1991 • 241 citations

Characterization of the Drosophila cactus locus and analysis of interactions between cactus and dorsal proteins

1992 • 230 citations

pelle encodes a protein kinase required to establish dorsoventral polarity in the Drosophila embryo

1993 • 210 citations

Spatially Restricted Expression of pipe in the Drosophila Egg Chamber Defines Embryonic Dorsal–Ventral Polarity

1998 • 208 citations

The multifunctional role of the co-activator CBP in transcriptional regulation.

1997 • 197 citations

Interleukin (IL)-1 Receptor–associated Kinase (IRAK) Requirement for Optimal Induction of Multiple IL-1 Signaling Pathways and IL-6 Production

1998 • 195 citations

Problems and paradigms: Morphogens and pattern formation

1997 • 184 citations

Cactus protein degradation mediates Drosophila dorsal-ventral signaling.

1995 • 183 citations

Proteolytic processing of the Drosophila Spätzle protein by Easter generates a dimeric NGF-like molecule with ventralising activity

1998 • 183 citations

A CBP/p300 homolog specifies multiple differentiation pathways in Caenorhabditis elegans

1998 • 176 citations

Conversion of Dorsal from an activator to a repressor by the global corepressor Groucho

1997 • 157 citations

Threshold responses to the dorsal regulatory gradient and the subdivision of primary tissue territories in the Drosophila embryo

1996 • 152 citations

The Groucho/Transducin-like Enhancer of split Transcriptional Repressors Interact with the Genetically Defined Amino-terminal Silencing Domain of Histone H3

1997 • 149 citations

The dorsal protein is distributed in a gradient in early drosophila embryos

1988 • 137 citations

Conversion of a dorsal-dependent silencer into an enhancer: evidence for dorsal corepressors.

1993 • 133 citations

Dissociation of the dorsal-cactus complex and phosphorylation of the dorsal protein correlate with the nuclear localization of dorsal.

1993 • 127 citations

A Gradient of Cactus Protein Degradation Establishes Dorsoventral Polarity in theDrosophilaEmbryo

1996 • 124 citations

Activation of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryo

1994 • 120 citations

A Role for Groucho Tetramerization in Transcriptional Repression

1998 • 119 citations

A gradient of cytoplasmic Cactus degradation establishes the nuclear localization gradient of the dorsal morphogen in Drosophila

1996 • 119 citations

Drosophila CBP is required for dorsal–dependent twist gene expression

1997 • 118 citations

Dorsal-Mediated Repression Requires the Formation of a Multiprotein Repression Complex at the Ventral Silencer

1998 • 114 citations

Genetic and molecular characterization of tube, a Drosophila gene maternally required for embryonic dorsoventral polarity.

1991 • 113 citations

Individual dorsal morphogen binding sites mediate activation and repression in the Drosophila embryo.

1992 • 104 citations

Dorsal, a Drosophila Rel-like protein, is phosphorylated upon activation of the transmembrane protein Toll.

1994 • 103 citations

An activity-dependent network of interactions links the Rel protein Dorsal with its cytoplasmic regulators

1997 • 102 citations

Nuclear import of the Drosophila Rel protein Dorsal is regulated by phosphorylation

1999 • 101 citations

Conversion of a silencer into an enhancer: evidence for a co-repressor in dorsal-mediated repression in Drosophila.

1993 • 100 citations

The Role of TAFs in RNA Polymerase II Transcription

1998 • 99 citations

The cAMP-dependent Protein Kinase Site (Ser312) Enhances Dorsal Nuclear Import through Facilitating Nuclear Localization Sequence/Importin Interaction

1998 • 92 citations

Binding sites for transcription factor NTF-1/Elf-1 contribute to the ventral repression of decapentaplegic.

1995 • 89 citations

Interactions between dorsal and helix-loop-helix proteins initiate the differentiation of the embryonic mesoderm and neuroectoderm in Drosophila.

1993 • 80 citations

The same dorsal binding site mediates both activation and repression in a context-dependent manner.

1992 • 76 citations

Interaction of the pelle kinase with the membrane-associated protein tube is required for transduction of the dorsoventral signal in Drosophila embryos

1995 • 71 citations

TAF _II mutations disrupt Dorsal activation in the Drosophila embryo

1998 • 69 citations

Recruitment of Tube and Pelle to signaling sites at the surface of the Drosophila embryo

1998 • 60 citations

A Direct Contact between the Dorsal rel Homology Domain and Twist May Mediate Transcriptional Synergy

1997 • 55 citations

Phosphorylation modulates direct interactions between the Toll receptor, Pelle kinase and Tube

1998 • 54 citations

Domain mapping of tube, a protein essential for dorsoventral patterning of the Drosophila embryo.

1993 • 42 citations

A multimeric complex and the nuclear targeting of the Drosophila Rel protein Dorsal

1997 • 36 citations

In vivo self-association of the Drosophila rel-protein dorsal.

1992 • 35 citations

The establishment and interpretation of transcription factor gradients in the Drosophila embryo

1995 • 35 citations

Regulated Nuclear Import of the Drosophila Rel Protein Dorsal: Structure-Function Analysis

1996 • 35 citations

Disulfide cross-linking in crude embryonic lysates reveals three complexes of the Drosophila morphogen dorsal and its inhibitor cactus.

1994 • 34 citations

Specificity of Rel-Inhibitor Interactions in Drosophila Embryos

1995 • 32 citations

Regulation of dorsal in cultured cells by Toll and tube: tube function involves a novel mechanism.

1995 • 27 citations

Chromatin Remodeling and Transcription

1998 • 12 citations