RNA-directed DNA methylation.

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

1998 • 14,674 citations

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

1998 • 3,363 citations

A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands.

1992 • 3,099 citations

Histone acetylation in chromatin structure and transcription

1997 • 2,834 citations

Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

1998 • 2,686 citations

High sensitivity mapping of methylated cytosines

1994 • 1,863 citations

Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA

1992 • 1,331 citations

Virus resistance and gene silencing in plants can be induced by simultaneous expression of sense and antisense RNA

1998 • 1,121 citations

Use of dsRNA-Mediated Genetic Interference to Demonstrate that frizzled and frizzled 2 Act in the Wingless Pathway

1998 • 1,116 citations

Viral pathogenicity determinants are suppressors of transgene silencing in Nicotiana benthamiana

1998 • 1,073 citations

RNA-directed de novo methylation of genomic sequences in plants

1994 • 929 citations

MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex

1999 • 898 citations

Tsix, a gene antisense to Xist at the X-inactivation centre

1999 • 809 citations

Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation

1999 • 806 citations

XIST RNA paints the inactive X chromosome at interphase: evidence for a novel RNA involved in nuclear/chromosome structure.

1996 • 787 citations

Systemic acquired silencing: transgene-specific post-transcriptional silencing is transmitted by grafting from silenced stocks to non-silenced scions

1997 • 777 citations

Double-stranded RNA induces mRNA degradation inTrypanosomabrucei

1998 • 705 citations

Systemic Spread of Sequence-Specific Transgene RNA Degradation in Plants Is Initiated by Localized Introduction of Ectopic Promoterless DNA

1998 • 694 citations

RNAi in C. elegans : Soaking in the Genome Sequence

1998 • 635 citations

RNA-triggered gene silencing

1999 • 623 citations

Imprinted expression of the Igf2r gene depends on an intronic CpG island

1997 • 578 citations

Double-stranded RNA specifically disrupts gene expression during planarian regeneration

1999 • 537 citations

How and Why Do Plants Inactivate Homologous (Trans)genes?

1995 • 518 citations

Targeted Mutagenesis of Tsix Leads to Nonrandom X Inactivation

1999 • 509 citations

DNA methylation and the regulation of globin gene expression

1983 • 451 citations

A maternally methylated CpG island in KvLQT1 is associated with an antisense paternal transcript and loss of imprinting in Beckwith–Wiedemann syndrome

1999 • 405 citations

Position effects and epigenetic silencing of plant transgenes

1998 • 402 citations

Transgene silencing of the al-1 gene in vegetative cells of Neurospora is mediated by a cytoplasmic effector and does not depend on DNA-DNA interactions or DNA methylation.

1996 • 373 citations

DNA methylation in plants

1987 • 373 citations

DNA methylation directs a time-dependent repression of transcription initiation

1997 • 372 citations

Listening to the silent genes: transgene silencing, gene regulation and pathogen control

1999 • 367 citations

Loss of imprinting of a paternally expressed transcript, with antisense orientation to K _V LQT1, occurs frequently in Beckwith–Wiedemann syndrome and is independent of insulin-like growth factor II imprinting

1999 • 360 citations

Targeted disruption of gene function in Drosophila by RNA interference (RNA-i): A role for nautilus in embryonic somatic muscle formation

1999 • 332 citations

Creation of genomic methylation patterns

1996 • 313 citations

RNA-Mediated RNA Degradation and Chalcone Synthase A Silencing in Petunia

1997 • 308 citations

Transgenic plant virus resistance mediated by untranslatable sense RNAs: expression, regulation, and fate of nonessential RNAs.

1994 • 295 citations

Expression of single copies of a strongly expressed 35S transgene can be silenced post‐transcriptionally

1996 • 291 citations

Position-effect variegation after 60 years

1990 • 286 citations

Posttranscriptional silencing of reporter transgenes in tobacco correlates with DNA methylation.

1994 • 284 citations

RNA as a target and an initiator of post-transcriptional gene silencing in trangenic plants

1996 • 284 citations

Neuronal Expression of Neural Nitric Oxide Synthase (nNOS) Protein Is Suppressed by an Antisense RNA Transcribed from an NOS Pseudogene

1999 • 274 citations

Isolation of an RNA-Directed RNA Polymerase–Specific cDNA Clone from Tomato

1998 • 251 citations

Multiple imprinted sense and antisense transcripts, differential methylation and tandem repeats in a putative imprinting control region upstream of mouse Igf2

1997 • 248 citations

Evidence that random and imprinted Xist expression is controlled by preemptive methylation

1994 • 247 citations

Arabidopsis Mutants Impaired in Cosuppression

1998 • 238 citations

Double-stranded RNA as a mediator in sequence-specific genetic silencing and co-suppression

1998 • 235 citations

Homology-dependent gene silencing in transgenic plants: epistatic silencing loci contain multiple copies of methylated transgenes

1994 • 233 citations

LIT1, an imprinted antisense RNA in the human KvLQT1 locus identified by screening for differentially expressed transcripts using monochromosomal hybrids

1999 • 229 citations

Production of aberrant promoter transcripts contributes to methylation and silencing of unlinked homologous promoters in trans

1999 • 228 citations

A Novel Imprinted Gene, Encoding a RING Zinc-Finger Protein, and Overlapping Antisense Transcript in the Prader-Willi Syndrome Critical Region

1999 • 225 citations

Taming of transposable elements by homology-dependent gene silencing

1999 • 221 citations

A model for RNA-mediated gene silencing in higher plants.

1998 • 213 citations

DNA methylation inhibits elongation but not initiation of transcription in Neurospora crassa

1997 • 202 citations

The Frequency and Degree of Cosuppression by Sense Chalcone Synthase Transgenes Are Dependent on Transgene Promoter Strength and Are Reduced by Premature Nonsense Codons in the Transgene Coding Sequence.

1997 • 196 citations

De novomethylation and co-suppression induced by a cytoplasmically replicating plant RNA virus

1998 • 195 citations

An Inverted Repeat Triggers Cytosine Methylation of Identical Sequences in Arabidopsis

1999 • 187 citations

Post‐transcriptional silencing of chalcone synthase in Petunia by inverted transgene repeats

1997 • 180 citations

Heavy de novo methylation at symmetrical and non-symmetrical sites is a hallmark of RNA-directed DNA methylation

1999 • 178 citations

Changes in T-DNA methylation and expression are associated with phenotypic variation and plant regeneration in a crown gall tumor line

1984 • 145 citations

Retraction: ‘Viral pathogenicity determinants are suppressors of transgene silencing in Nicotiana benthamiana’

2015 • 144 citations

Position-Dependent Methylation and Transcriptional Silencing of Transgenes in Inverted T-DNA Repeats: Implications for Posttranscriptional Silencing of Homologous Host Genes in Plants

1998 • 143 citations

Ectopic pairing of homologous DNA and post-transcriptional gene silencing in transgenic plants

1996 • 141 citations

Imaging of viroids in nuclei from tomato leaf tissue by in situ hybridization and confocal laser scanning microscopy.

1989 • 140 citations

A Gene Essential for De Novo Methylation and Development in Ascobolus Reveals a Novel Type of Eukaryotic DNA Methyltransferase Structure

1997 • 134 citations

Interchromosomal Transfer of Epigenetic States in Ascobolus: Transfer of DNA Methylation Is Mechanistically Related to Homologous Recombination

1996 • 132 citations

Genome intruder scanning and modulation systems and transgene silencing

1998 • 129 citations

Genomic Imprinting and Cancer

2006 • 128 citations

Cytosine methylation of repeated sequences in eukaryotes: the role of DNA pairing

1998 • 121 citations

Methylation induced premeiotically in Ascobolus: coextension with DNA repeat lengths and effect on transcript elongation.

1993 • 120 citations

Identification of a general silencer for 19S and 35S promoters in a transgenic tobacco plant : 90 bp of homology in the promoter sequence are sufficient for trans-inactivation

1993 • 117 citations

Competition- a common motif for the imprinting mechanism?

1997 • 115 citations

A DNA target of 30 bp is sufficient for RNA-directed DNA methylation

2000 • 115 citations

Mechanisms of heritable gene repression during development of Drosophila

1993 • 113 citations

Formation of a thermodynamically metastable structure containing hairpin II is critical for infectivity of potato spindle tuber viroid RNA.

1991 • 113 citations

Review

1998 • 110 citations

Inhibition of tobacco nitrite reductase activity by expression of antisense RNA

1992 • 109 citations

Epigenetic silencing of plant transgenes as a consequence of diverse cellular defence responses

1998 • 105 citations

Activation of systemic acquired silencing by localised introduction of DNA

1999 • 96 citations

Chromatin-mediated transcription repression in yeast

1995 • 94 citations

Methylation of coding region alone inhibits gene expression in plant protoplasts.

1996 • 89 citations

Post‐transcriptional silencing of a neomycin phosphotransferase II transgene correlates with the accumulation of unproductive RNAs and with increased cytosine methylation of 3′ flanking regions

1997 • 87 citations

Detection of cytosine methylation in the maize alcohol dehydrogenase gene by genomic sequencing

1986 • 83 citations

Cytosine methylation at CG and CNG sites is not a prerequisite for the initiation of transcriptional gene silencing in plants, but it is required for its maintenance

1998 • 71 citations

Bisulfite Genomic Sequencing-Derived Methylation Profile of theXistGene throughout Early Mouse Development

1998 • 65 citations

Sex in the '90s

1995 • 54 citations

Homology-Dependent Silencing of the SC3 Gene in Schizophyllum commune

1997 • 51 citations

Lack of Reciprocal Genomic Imprinting of Sense and Antisense RNA of Mouse Insulin-like Growth Factor II Receptor in the Central Nervous System1

1999 • 47 citations

Promoter-dependent trans-inactivation in transgenic tobacco plants : kinetic aspects of gene silencing and gene reactivation

1994 • 45 citations

Molecular Cloning of Antisense Transcripts of the MouseXistGene

1999 • 41 citations

Telomere maintenance and gene repression: a common end?

1994 • 39 citations

The Formation of DNA Methylation Patterns and the Silencing of Genes

1997 • 35 citations

Do unintended antisense transcripts contribute to sense cosuppression in plants?

1999 • 32 citations

Silencing speaks up

1994 • 26 citations

Stalling of DNA methyltransferase in chromosome stability and chromosome remodelling (Review).

1998 • 24 citations

Sequences throughout the basic β‐1,3‐glucanase mRNA coding region are targets for homology dependent post‐transcriptional gene silencing

1999 • 22 citations

Signalling in gene silencing

1999 • 22 citations

Constitutive and light-induced DNAseI hypersensitive sites in the rbcS genes of pea (Pisum sativum)

1988 • 19 citations

Deleted Work

1955 • 0 citations