Evidence that random and imprinted Xist expression is controlled by preemptive methylation

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

1992 • 3,907 citations

Gene Action in the X-chromosome of the Mouse (Mus musculus L.)

1961 • 3,881 citations

CpG-rich islands and the function of DNA methylation

1986 • 3,760 citations

A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome

1991 • 1,469 citations

The human XIST gene: Analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus

1992 • 1,269 citations

HPRT-deficient (Lesch–Nyhan) mouse embryos derived from germline colonization by cultured cells

1987 • 1,231 citations

Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development

1987 • 1,088 citations

The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus

1992 • 983 citations

The essentials of DNA methylation

1992 • 960 citations

Preferential inactivation of the paternally derived X chromosome in the extraembryonic membranes of the mouse

1975 • 783 citations

Differentiation of clonal lines of teratocarcinoma cells: formation of embryoid bodies in vitro.

1975 • 710 citations

A fraction of the mouse genome that is derived from islands of nonmethylated, CpG-rich DNA

1985 • 668 citations

Conservation of position and exclusive expression of mouse Xist from the inactive X chromosome

1991 • 617 citations

Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal

1993 • 602 citations

An assessment of the developmental potential of embryonic stem cells in the midgestation mouse embryo

1989 • 596 citations

Characterization of a murine gene expressed from the inactive X chromosome

1991 • 529 citations

Epigenetic mechanisms underlying the imprinting of the mouse H19 gene.

1993 • 493 citations

Parental legacy determines methylation and expression of an autosomal transgene: A molecular mechanism for parental imprinting

1987 • 478 citations

Substrate and sequence specificity of a eukaryotic DNA methylase

1982 • 441 citations

Parental-origin-specific epigenetic modification of the mouse H19 gene

1993 • 419 citations

Localization of the X inactivation centre on the human X chromosome in Xq13

1991 • 380 citations

Expression of Xist during mouse development suggests a role in the initiation of X chromosome inactivation

1993 • 369 citations

The somatic replication of DNA methylation

1981 • 368 citations

Two DNA methyltransferases from murine erythroleukemia cells: purification, sequence specificity, and mode of interaction with DNA.

1983 • 361 citations

Establishment of germ-line-competent embryonic stem (ES) cells using differentiation inhibiting activity

1990 • 332 citations

X-chromosome inactivation and cell memory

1992 • 329 citations

Preferential expression of the maternally derived X chromosome in the mouse yolk sac

1977 • 328 citations

Sequential X chromosome inactivation coupled with cellular differentiation in early mouse embryos

1979 • 284 citations

Teratocarcinomas and Embryonic Stem Cells: A Practical Approach

1988 • 263 citations

Parental-specific methylation of an imprinted transgene is established during gametogenesis and progressively changes during embryogenesis

1991 • 246 citations

Chapter 2 Separation of Spermatogenic Cells and Nuclei from Rodent Testes

1977 • 212 citations

X-chromosome deletions in embryo-derived (EK) cell lines associated with lack of X-chromosome inactivation

1985 • 208 citations

Non-random X-chromosome inactivation in mouse X-autosome translocation embryos—location of the inactivation centre

1983 • 208 citations

X inactivation in mammalian testis is correlated with inactive X–specific transcription

1992 • 160 citations

Transformation with DNA from 5-azacytidine-reactivated X chromosomes.

1982 • 149 citations

Expression of Xist in mouse germ cells correlates with X–chromosome inactivation

1992 • 143 citations

A Mouse Translocation Suppressing Sex-Linked Variegation

1964 • 142 citations

Expression of the X–inactivation–associated gene XIST during spermatogenesis

1992 • 140 citations

Mammalian Development: A Practical Approach

1988 • 140 citations

Morphological and temporal sequence of meiotic prophase development at puberty in the male mouse

1984 • 135 citations

X-chromosome inactivation may explain the difference in viability of XO humans and mice

1991 • 128 citations

Methylation status of CpG-rich islands on active and inactive mouse X chromosomes

1991 • 114 citations

Controlling elements in the mouse: IV. Evidence of non-randomX-inactivation

1981 • 113 citations

Cell interactions and endoderm differentiation in cultured mouse embryos

1981 • 110 citations

Changes in DNA methylation during mouse embryonic development in relation to X-chromosome activity and imprinting

1990 • 104 citations

Decrease in DNA methylase activity during preimplantation development in the mouse

1991 • 94 citations

Parental source of chromosome imprinting and its relevance for X chromosome inactivation

1984 • 92 citations

Separation of germ layers in presomite rat embryos

1969 • 85 citations

Mouse embryo stem cells: their identification, propagation and manipulation

1992 • 80 citations

The search for the mouse X-chromosome inactivation centre

1990 • 80 citations

Epigenetic inheritance in mammals

1993 • 79 citations

Patterning of connective tissues in the head: discussion report

1988 • 76 citations

Influence of chromosomal determinants on development of androgenetic and parthenogenetic cells

1988 • 59 citations

Genetic Basis for Graft-against-Host Immunological Reactions between Two Inbred Lines of Chickens

1961 • 32 citations

Imprints on islands

1993 • 20 citations

X chromosome retains the memory of its parental origin in murine embryonic stem cells

1993 • 19 citations

Chromosome jumping from flanking markers defines the minimal region for alf/hsdr-1 within the albino-deletion complex

1992 • 18 citations