DNA methylation and the regulation of globin gene expression

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments

1982 • 3,041 citations

Purification of Mouse Immunoglobulin Heavy‐Chain Messenger RNAs from Total Myeloma Tumor RNA

1980 • 2,696 citations

DNA Methylation and Gene Function

1980 • 2,069 citations

Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells

1977 • 1,411 citations

Human fetal gγ- and Aγ-globin genes: Complete nucleotide sequences suggest that DNA can be exchanged between these duplicated genes

1980 • 947 citations

DNA methylation in the human γδβ-globin locus in erythroid and nonerythroid tissues

1980 • 634 citations

Active chromatin

1982 • 549 citations

5-Azacytidine Selectively Increases γ-Globin Synthesis in a Patient with β⁺Thalassemia

1982 • 496 citations

Formation of stable preinitiation complexes between eukaryotic class B transcription factors and promoter sequences

1983 • 477 citations

Use of restriction enzymes to study eukaryotic DNA methylation

1978 • 442 citations

Specific DNA methylation sites in the vicinity of the chicken β-globin genes

1979 • 365 citations

DNA methylation: organ specific variations in the methylation pattern within and around ovalbumin and other chicken genes

1979 • 356 citations

A history of the human fetal globin gene duplication

1981 • 349 citations

The construction of cosmid libraries which can be used to transform eukaryotic cells

1982 • 319 citations

In vitro methylation of the hamster adenine phosphoribosyltransferase gene inhibits its expression in mouse L cells.

1982 • 271 citations

DNA methylation at a CCGG sequence in the large intron of the rabbit β-globin gene: tissue-specific variations

1978 • 268 citations

β+ Thalassemia: Aberrant splicing results from a single point mutation in an intron

1981 • 235 citations

Clonal inheritance of the pattern of DNA methylation in mouse cells.

1982 • 229 citations

Methylation of foreign DNA sequences in eukaryotic cells.

1980 • 190 citations

Expression of a cloned adenovirus gene is inhibited by in vitro methylation.

1982 • 184 citations

Asymmetrical distribution of CpG in an ‘average’ mammalian gene

1982 • 140 citations

Undermethylation at the 5′ end of the albumin gene is necessary but not sufficient for albumin production by rat hepatoma cells in culture

1982 • 124 citations

Changes in the helical repeat of poly(dG-m5 dC) · poly(dG-m5dC) and poly(dG-dC) · poly(dG-dC) associated with the B—Z transition

1981 • 94 citations

Methylation of simian virus 40 Hpa II site affects late, but not early, viral gene expression.

1982 • 85 citations

The unmethylated state of the promoter/leader and 5′-regions of integrated adenovirus genes correlates with gene expression.

1982 • 79 citations

Modulation of transfected gene expression mediated by changes in chromatin structure

1982 • 72 citations

Isolation and partial sequence of recombinant plasmids containing human α-, β- and γ-globin cDNA fragments

1978 • 67 citations