Targeted Mutagenesis of Tsix Leads to Nonrandom X Inactivation

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

1992 • 3,907 citations

Gene Action in the X-chromosome of the Mouse (Mus musculus L.)

1961 • 3,881 citations

The human XIST gene: Analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus

1992 • 1,269 citations

Requirement for Xist in X chromosome inactivation

1996 • 995 citations

The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus

1992 • 983 citations

Tsix, a gene antisense to Xist at the X-inactivation centre

1999 • 809 citations

XIST RNA paints the inactive X chromosome at interphase: evidence for a novel RNA involved in nuclear/chromosome structure.

1996 • 787 citations

Preferential inactivation of the paternally derived X chromosome in the extraembryonic membranes of the mouse

1975 • 783 citations

Differentiation of clonal lines of teratocarcinoma cells: formation of embryoid bodies in vitro.

1975 • 710 citations

X‐CHROMOSOME INACTIVATION AND DEVELOPMENTAL PATTERNS IN MAMMALS

1972 • 657 citations

MAMMALIAN X-CHROMOSOME INACTIVATION

1983 • 635 citations

Highly localized tracks of specific transcripts within interphase nuclei visualized by in situ hybridization

1989 • 434 citations

DNA hypomethylation can activate Xist expression and silence X-linked genes.

1996 • 377 citations

Fluorescence in situ hybridization: applications in cytogenetics and gene mapping

1991 • 375 citations

A 450 kb Transgene Displays Properties of the Mammalian X-Inactivation Center

1996 • 315 citations

Fluorescence in situ hybridization

1993 • 308 citations

X Chromosome Inactivation Is Mediated by Xist RNA Stabilization

1997 • 294 citations

A promoter mutation in the XIST gene in two unrelated families with skewed X-chromosome inactivation

1997 • 290 citations

Sequential X chromosome inactivation coupled with cellular differentiation in early mouse embryos

1979 • 284 citations

Long-range cis effects of ectopic X-inactivation centres on a mouse autosome

1997 • 268 citations

Fluorescence in situ hybridization: applications in cytogenetics and gene mapping

1991 • 262 citations

Xist has properties of the X-chromosome inactivation centre

1997 • 248 citations

Stabilization of Xist RNA Mediates Initiation of X Chromosome Inactivation

1997 • 247 citations

Both X chromosomes function before visible X-chromosome inactivation in female mouse embryos

1978 • 219 citations

X-chromosome deletions in embryo-derived (EK) cell lines associated with lack of X-chromosome inactivation

1985 • 208 citations

Production of targeted embryonic stem cell clones

1999 • 204 citations

Laboratory Protocols for Conditional Gene Targeting

1997 • 176 citations

Phosphoglycerate Kinase Polymorphism in Kangaroos provides Further Evidence for Paternal X Inactivation

1971 • 175 citations

Role of the region 3′ to Xist exon 6 in the counting process of X-chromosome inactivation

1998 • 168 citations

The Igκ 3′ Enhancer Influences the Ratio of Igκ versus Igλ B Lymphocytes

1996 • 166 citations

EVOLUTION OF SEX CHROMOSOMES IN MAMMALS

1969 • 164 citations

Role of the Xist Gene in X Chromosome Choosing

1998 • 157 citations

Possible Mechanisms of X Chromosome Inactivation

1971 • 133 citations

HGPRT activity changes in preimplantation mouse embryos

1978 • 128 citations

X-Autosome Translocations in The Mouse: Total Inactivation Versus Partial Inactivation Of The X Chromosome

1970 • 115 citations

Genetic analysis of the mouse X inactivation center defines an 80-kb multifunction domain

1999 • 114 citations

Xce haplotypes show modified methylation in a region of the active X chromosome lying 3' to Xist.

1995 • 111 citations

Mapping the murine Xce locus with (CA)n repeats

1993 • 110 citations

Evolutionary conservation of possible functional domains of the human and murine XIST genes

1993 • 107 citations

X-chromosome inactivation mosaicism in the three germ layers and the germ line of the mouse embryo

1983 • 102 citations

The search for the mouse X-chromosome inactivation centre

1990 • 80 citations

Production of chimeras and genetically defined offspring from targeted ES cells.

1993 • 68 citations

The role of Xist in X-inactivation

1998 • 66 citations

Tissue and lineage-specific variation in inactive X chromosome expression of the murine Smcx gene

1996 • 65 citations

Controlling elements in the mouse: V. Linkage tests with X-linked genes

1981 • 54 citations

Genetically directed preferential X-activation seen in mice

1974 • 52 citations

Molecular correlates of the murine Xce locus

1998 • 29 citations