Epigenetic silencing of plant transgenes as a consequence of diverse cellular defence responses

CpG-rich islands and the function of DNA methylation

1986 • 3,760 citations

Introduction of a Chimeric Chalcone Synthase Gene into Petunia Results in Reversible Co-Suppression of Homologous Genes in trans.

1990 • 2,386 citations

Cytosine methylation and the ecology of intragenomic parasites

1997 • 1,906 citations

Flavonoid genes in petunia: addition of a limited number of gene copies may lead to a suppression of gene expression.

1990 • 1,182 citations

Stomatal Size in Fossil Plants: Evidence for Polyploidy in Majority of Angiosperms

1994 • 1,162 citations

A Similarity Between Viral Defense and Gene Silencing in Plants

1997 • 821 citations

Induction of a Highly Specific Antiviral State in Transgenic Plants: Implications for Regulation of Gene Expression and Virus Resistance.

1993 • 734 citations

PLANT TRANSFORMATION: Problems and Strategies for Practical Application

1997 • 625 citations

Transposable elements as sources of variation in animals and plants

1997 • 569 citations

Reversible methylation and inactivation of marker genes in sequentially transformed tobacco plants

1989 • 544 citations

Simple sequence repeats as a source of quantitative genetic variation

1997 • 460 citations

Mechanisms of Pathogen-Derived Resistance to Viruses in Transgenic Plants.

1996 • 437 citations

Hypermethylated SUPERMAN Epigenetic Alleles in Arabidopsis

1997 • 428 citations

Transgene Inactivation: Plants Fight Back!

1994 • 413 citations

Plants combat infection by gene silencing

1997 • 384 citations

THE HUMAN GENOME: Organization and Evolutionary History

1995 • 375 citations

Suppression of Virus Accumulation in Transgenic Plants Exhibiting Silencing of Nuclear Genes.

1996 • 375 citations

The highest gene concentrations in the human genome are in telomeric bands of metaphase chromosomes.

1992 • 342 citations

HOMOLOGY-DEPENDENT GENE SILENCING IN PLANTS

1996 • 342 citations

Creation of genomic methylation patterns

1996 • 313 citations

Suppression of beta-1,3-glucanase transgene expression in homozygous plants.

1992 • 303 citations

Transgene‐mediated suppression of chalcone synthase expression in Petunia hybrida results from an increase in RNA turnover

1994 • 297 citations

Vertebrate evolution by interspecific hybridisation – are we polyploid?

1997 • 291 citations

Expression of single copies of a strongly expressed 35S transgene can be silenced post‐transcriptionally

1996 • 291 citations

Gene silencing mediated by promoter homology occurs at the level of transcription and results in meiotically heritable alterations in methylation and gene activity

1996 • 286 citations

Posttranscriptional silencing of reporter transgenes in tobacco correlates with DNA methylation.

1994 • 284 citations

Epigenetic repeat-induced gene silencing (RIGS) inArabidopsis

1993 • 283 citations

Retrotransposons in the flanking regions of normal plant genes: a role for copia-like elements in the evolution of gene structure and expression.

1994 • 281 citations

DNA sequence insertion and evolutionary variation in gene regulation.

1996 • 251 citations

Cosuppression, Flower Color Patterns, and Metastable Gene Expression States

1995 • 243 citations

Post-transcriptional gene silencing in plants

1997 • 241 citations

Homology-dependent gene silencing in transgenic plants: epistatic silencing loci contain multiple copies of methylated transgenes

1994 • 233 citations

Differences in DNA‐methylation are associated with a paramutation phenomenon in transgenic petunia

1993 • 219 citations

The contributions of retroelements to plant genome organization, function and evolution

1996 • 217 citations

A computer-based systematic survey reveals the predominance of small inverted-repeat elements in wild-type rice genes.

1996 • 210 citations

Molecular and cytogenetic analyses of stably and unstably expressed transgene loci in tobacco.

1997 • 210 citations

The Frequency and Degree of Cosuppression by Sense Chalcone Synthase Transgenes Are Dependent on Transgene Promoter Strength and Are Reduced by Premature Nonsense Codons in the Transgene Coding Sequence.

1997 • 196 citations

RNA-Mediated Virus Resistance: Role of Repeated Transgenes and Delineation of Targeted Regions.

1996 • 196 citations

A chromosome region-specific mapping strategy reveals gene-rich telomeric ends in wheat

1993 • 189 citations

Post‐transcriptional silencing of chalcone synthase in Petunia by inverted transgene repeats

1997 • 180 citations

Gene inactivation triggered by recognition between DNA repeats

1994 • 144 citations

Compositional compartmentalization and compositional patterns in the nuclear genomes of plants

1988 • 143 citations

Ectopic pairing of homologous DNA and post-transcriptional gene silencing in transgenic plants

1996 • 141 citations

The use of combined FISH/GISH in conjunction with DAPI counterstaining to identify chromosomes containing transgene inserts in amphidiploid tobacco.

1996 • 139 citations

Paramutation and transgene silencing: a common response to invasive DNA?

1996 • 139 citations

Differential inactivation and methylation of a transgene in plants by two suppressor loci containing homologous sequences

1991 • 138 citations

Paramutation and related allelic interactions

1997 • 135 citations

Interchromosomal Transfer of Epigenetic States in Ascobolus: Transfer of DNA Methylation Is Mechanistically Related to Homologous Recombination

1996 • 132 citations

Epigenetic variants of a transgenic petunia line show hypermethylation in transgene DNA: an indication for specific recognition of foreign DNA in transgenic plants

1994 • 121 citations

Identification of a general silencer for 19S and 35S promoters in a transgenic tobacco plant : 90 bp of homology in the promoter sequence are sufficient for trans-inactivation

1993 • 117 citations

Nuclear organization and gene expression: homologous pairing and long-range interactions

1997 • 86 citations

Organization of paramutagenicity in R-stippled maize.

1995 • 86 citations

Transgene inactivation inPetunia hybrida is influenced by the properties of the foreign gene

1995 • 82 citations

Comparison of cloned genes provides evidence for intergenomic exchange of DNA in the evolution of a tobacco glucan endo-1,3-beta-glucosidase gene family.

1991 • 82 citations

Structural instability of a transgene locus in tobacco is associated with aneuploidy

1996 • 62 citations

Inactivation of Repeated Genes — DNA-DNA Interaction?

1994 • 61 citations

Polite DNA: Functional density and functional compatibility in genomes

1986 • 51 citations

THE EARLY YEARS OF MAIZE GENETICS

1984 • 50 citations

A repetitive DNA fragment carrying a hot spot for de novo DNA methylation enhances expression variegation in tobacco and petunia

1995 • 46 citations

Compostitional bimodality of the nuclear genome of tabacco

1991 • 43 citations

Methylation sites in angiosperm genes

1992 • 37 citations

Transposable elements and the evolution of gene expression.

1998 • 35 citations

Non-random distribution of transposable elements in the nuclear genome of plants

1993 • 26 citations

Gene Silencing in Plants: Relevance for Genome Evolution and the Acquisition of Genomica Methylation Patterns

2007 • 22 citations

Epigene conversion: a proposal with implications for gene mapping in humans.

1992 • 19 citations

Epigenetic Regulation of the Maize Spm Transposable Element

1996 • 16 citations

Deleted Work

1955 • 0 citations